Recent Applications of Ionic Liquids in Separation Technology

Ionic liquids (ILs) have been applied in different areas of separation, such as ionic liquid supported membranes, as mobile phase additives and surface-bonded stationary phases in chromatography separations and as the extraction solvent in sample preparations, because they can be composed from various cations and anions that change the properties and phase behavior of liquids. Although the applications of ILs in separations are still in their early stages, the academic interest in ILs is increasing. An overview of the principle applications of ILs in separation technology is present in this work. Furthermore, the prospects of the ILs in separation techniques are discussed.

[1]  Wei-Xin Hu,et al.  Ionic liquid-based ultrasound-assisted dispersive liquid–liquid microextraction combined with electrothermal atomic absorption spectrometry for a sensitive determination of cadmium in water samples , 2009 .

[2]  R. Germani,et al.  Mercury extraction by ionic liquids: temperature and alkyl chain length effect , 2007 .

[3]  Jung Min Lee,et al.  Preparation of supported ionic liquid membranes (SILMs) for the removal of acidic gases from crude natural gas , 2009 .

[4]  Y. Koo,et al.  Effect of mobile phase additives on resolution of some nucleic compounds in high performance liquid chromatography , 2007 .

[5]  Wenyan Ma,et al.  Application of ionic liquids based microwave-assisted extraction of three alkaloids N-nornuciferine, O-nornuciferine, and nuciferine from lotus leaf. , 2010, Talanta.

[6]  Jing-fu Liu,et al.  Disposable ionic liquid coating for headspace solid-phase microextraction of benzene, toluene, ethylbenzene, and xylenes in paints followed by gas chromatography-flame ionization detection. , 2005, Journal of chromatography. A.

[7]  Antonio V. Herrera-Herrera,et al.  Pesticide extraction from table grapes and plums using ionic liquid based dispersive liquid–liquid microextraction , 2009, Analytical and bioanalytical chemistry.

[8]  A. Ouadi,et al.  Task-specific ionic liquids bearing 2-hydroxybenzylamine units: synthesis and americium-extraction studies. , 2006, Chemistry.

[9]  Xiao-hua Xiao,et al.  Application of ionic liquids in the microwave-assisted extraction of polyphenolic compounds from medicinal plants. , 2009, Talanta.

[10]  K. Row,et al.  Retention factors and resolutions of amino benzoic acid isomers with some lonic liquids , 2006 .

[11]  M. Amjadi,et al.  Hollow fiber based-liquid phase microextraction using ionic liquid solvent for preconcentration of lead and nickel from environmental and biological samples prior to determination by electrothermal atomic absorption spectrometry. , 2010, Journal of hazardous materials.

[12]  K. Row,et al.  Effect of concentration of ionic liquids on resolution of nucleotides in reversed-phase liquid chromatography , 2007 .

[13]  F. Borrull,et al.  Supported imidazolium ionic liquid phases: a new material for solid-phase extraction. , 2009, Talanta.

[14]  F. Zhao,et al.  Coupling of ionic liquid-based headspace single-drop microextraction with GC for sensitive detection of phenols. , 2008, Journal of separation science.

[15]  V. Pino,et al.  Ionic liquids as mobile phase additives in high-performance liquid chromatography with electrochemical detection: application to the determination of heterocyclic aromatic amines in meat-based infant foods. , 2009, Talanta.

[16]  Kyung Ho Row,et al.  Retention‐Eluent Composition Relationships of Some Polar Compounds with Imidazolium Ionic Liquid Modifiers in RP‐HPLC , 2007 .

[17]  Y. Koo,et al.  Application of ionic liquids as mobile phase modifier in HPLC , 2006 .

[18]  R. Noble,et al.  Effect of “Free” Cation Substituent on Gas Separation Performance of Polymer−Room-Temperature Ionic Liquid Composite Membranes , 2009 .

[19]  Liang Zhao,et al.  Effect of 1-alkyl-3-methylimidazolium-based ionic liquids as the eluent on the separation of ephedrines by liquid chromatography. , 2003, Journal of chromatography. A.

[20]  R. P. Swatloski,et al.  Task-specific ionic liquids incorporating novel cations for the coordination and extraction of Hg2+ and Cd2+: synthesis, characterization, and extraction studies. , 2002, Environmental science & technology.

[21]  K. Row,et al.  Separation of Guanine and Hypoxanthine with Some Ionic Liquids in RP-HPLC , 2006 .

[22]  Qian Wang,et al.  Surface confined ionic liquid as a stationary phase for HPLC. , 2006, The Analyst.

[23]  Liang Zhao,et al.  Novel imidazolium stationary phase for high-performance liquid chromatography. , 2006, Journal of chromatography. A.

[24]  Xiaoji Cao,et al.  Ionic liquid-based ultrasonic-assisted extraction of piperine from white pepper. , 2009, Analytica chimica acta.

[25]  XiaLiu,et al.  Surface Confined Ionic Liquid—A New Stationary Phase for the Separation of Ephedrines in High-performance Liquid Chromatography , 2004 .

[26]  M. Amjadi,et al.  Ultra-trace determination of lead in water and food samples by using ionic liquid-based single drop microextraction-electrothermal atomic absorption spectrometry. , 2009, Analytica chimica acta.

[27]  P. Kubisa.  Ionic liquids as solvents for polymerization processes—Progress and challenges , 2009 .

[28]  M. Goto,et al.  Use of ionic liquids in a lipase-facilitated supported liquid membrane , 2003, Biotechnology Letters.

[29]  Ziniu Yu,et al.  Ultrasound assisted ionic liquid dispersive liquid phase extraction of lovastatin and simvastatin: a new pretreatment procedure. , 2009, Journal of separation science.

[30]  Jing-fu Liu,et al.  Direct determination of chlorophenols in environmental water samples by hollow fiber supported ionic liquid membrane extraction coupled with high-performance liquid chromatography. , 2007, Journal of chromatography. A.

[31]  L. Nie,et al.  Determination of octopamine, synephrine and tyramine in Citrus herbs by ionic liquid improved 'green' chromatography. , 2006, Journal of chromatography. A.

[32]  R. Compton,et al.  The electrochemical reduction of the purines guanine and adenine at platinum electrodes in several room temperature ionic liquids. , 2010, Analytica chimica acta.

[33]  K. Row,et al.  RETENTION BEHAVIOUR OF N-CBZ-D-PHENYLALANINE AND D-TRYPTOPHAN: EFFECT OF IONIC LIQUID AS MOBILE-PHASE MODIFIER , 2006 .

[34]  I. Sun,et al.  Nafion membrane-supported ionic liquid–solid phase microextraction for analyzing ultra trace PAHs in water samples , 2006 .

[35]  R. Kaliszan,et al.  Evaluation of the silanol-suppressing potency of ionic liquids. , 2006, Journal of separation science.

[36]  M. J. Neiva Correia,et al.  Studies on the Use of Ionic Liquids as Potential Extractants of Phenolic Compounds and Metal Ions , 2005 .

[37]  Qilong Ren,et al.  Selective Separation of Tocopherol Homologues by Liquid−Liquid Extraction Using Ionic Liquids , 2009 .

[38]  Jing Fan,et al.  Solvent extraction of selected endocrine-disrupting phenols using ionic liquids , 2008 .

[39]  D. Dionysiou,et al.  Photolytic degradation of chlorinated phenols in room temperature ionic liquids , 2004 .

[40]  V. Pino,et al.  The ionic liquid 1-hexadecyl-3-methylimidazolium bromide as novel extracting system for polycyclic aromatic hydrocarbons contained in sediments using focused microwave-assisted extraction. , 2008, Journal of chromatography. A.

[41]  Zhiqiang Zhou,et al.  Determination of four heterocyclic insecticides by ionic liquid dispersive liquid-liquid microextraction in water samples. , 2009, Journal of chromatography. A.

[42]  Antonio V. Herrera-Herrera,et al.  Ionic liquids as mobile phase additives for the high-performance liquid chromatographic analysis of fluoroquinolone antibiotics in water samples , 2008, Analytical and bioanalytical chemistry.

[43]  Lijun He,et al.  Effect of Ionic Liquids as Mobile Phase Additives on Retention of Catecholamines in Reversed-Phase High-Performance Liquid Chromatography , 2003 .

[44]  Zusing Yang,et al.  Room temperature ionic liquid as a novel medium for liquid/liquid extraction of metal ions , 2003 .

[45]  R. Balasubramanian,et al.  Ionic liquid supported three-phase liquid-liquid-liquid microextraction as a sample preparation technique for aliphatic and aromatic hydrocarbons prior to gas chromatography-mass spectrometry. , 2008, Journal of chromatography. A.

[46]  W. Bi,et al.  Comparison of Different Silica-Based Imidazolium Stationary Phases for LC in Separation of Alkaloids , 2010 .

[47]  Hongyuan Yan,et al.  Solid-phase extraction of tanshinones from Salvia Miltiorrhiza Bunge using ionic liquid-modified silica sorbents. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[48]  F. Marken,et al.  An ionic liquid as a solvent for headspace single drop microextraction of chlorobenzenes from water samples. , 2007, Analytica chimica acta.

[49]  Cj Cor Peters,et al.  A potential ionic liquid for CO2-separating gas membranes: selection and gas solubility studies , 2009 .

[50]  Chao Tai,et al.  Ionic liquid for high temperature headspace liquid-phase microextraction of chlorinated anilines in environmental water samples. , 2005, Journal of chromatography. A.

[51]  Jared L. Anderson,et al.  Dispersive liquid–liquid microextraction using an in situ metathesis reaction to form an ionic liquid extraction phase for the preconcentration of aromatic compounds from water , 2009, Analytical and bioanalytical chemistry.

[52]  Jared L. Anderson,et al.  Retention characteristics of organic compounds on molten salt and ionic liquid-based gas chromatography stationary phases. , 2009, Journal of chromatography. A.

[53]  Jason E. Bara,et al.  Gas separations in fluoroalkyl-functionalized room-temperature ionic liquids using supported liquid membranes , 2009 .

[54]  L. Neves,et al.  Separation of biohydrogen by supported ionic liquid membranes , 2009 .

[55]  Qingxiang Zhou,et al.  Ultrasound-assisted ionic liquid dispersive liquid-phase micro-extraction: a novel approach for the sensitive determination of aromatic amines in water samples. , 2009, Journal of chromatography. A.

[56]  H. Bai,et al.  Temperature-controlled ionic liquid dispersive liquid phase micro-extraction. , 2008, Journal of chromatography. A.

[57]  Yu Yanying,et al.  Extraction of Ferulic Acid and Caffeic Acid with Ionic Liquids , 2007 .

[58]  Liu Xia,et al.  Ionic liquids as additives in high performance liquid chromatography: Analysis of amines and the interaction mechanism of ionic liquids , 2004 .

[59]  Yang Shu,et al.  Selective extraction/isolation of hemoglobin with ionic liquid 1-butyl-3-trimethylsilylimidazolium hexafluorophosphate (BtmsimPF6). , 2008, Talanta.

[60]  Robin D. Rogers,et al.  Traditional Extractants in Nontraditional Solvents: Groups 1 and 2 Extraction by Crown Ethers in Room-Temperature Ionic Liquids† , 2000 .

[61]  A. Stalcup,et al.  Separation of peptides by HPLC using a surface-confined ionic liquid stationary phase , 2010, Analytical and bioanalytical chemistry.

[62]  Jared L. Anderson,et al.  Binary ionic liquid mixtures as gas chromatography stationary phases for improving the separation selectivity of alcohols and aromatic compounds. , 2008, Journal of chromatography. A.

[63]  Wenyan Ma,et al.  Ionic liquid-based microwave-assisted extraction of phenolic alkaloids from the medicinal plant Nelumbo nucifera Gaertn. , 2008, Journal of chromatography. A.

[64]  Qingxiang Zhou,et al.  Ionic liquid for improved single-drop microextraction of aromatic amines in water samples , 2008 .

[65]  J. Flieger.  Effect of Ionic Liquids as Mobile-Phase Additives on Chromatographic Parameters of Neuroleptic Drugs in Reversed-Phase High-Performance Liquid Chromatography , 2009 .

[66]  Robin D. Rogers,et al.  Characterization and comparison of hydrophilic and hydrophobic room temperature ionic liquids incorporating the imidazolium cation , 2001 .

[67]  J. Bazureau,et al.  Synthesis of 3,5-disubstituted 1,2,4-oxadiazoles using ionic liquid-phase organic synthesis (IoLiPOS) methodology , 2010 .

[68]  R. Kaliszan,et al.  Reduction of silanophilic interactions in liquid chromatography with the use of ionic liquids , 2005 .

[69]  P. Izák,et al.  Selective removal of acetone and butan-1-ol from water with supported ionic liquid-polydimethylsiloxane membrane by pervaporation. , 2008 .

[70]  Kyung Ho Row,et al.  Effect of Concentration of Ionic Liquid 1‐Butyl‐3‐Methylimidazolium, Tetrafuoroborate, for Retention and Separation of Some Amino and Nucleic Acids , 2006 .

[71]  H. Qiu,et al.  N-Methylimidazolium anion-exchange stationary phase for high-performance liquid chromatography. , 2006, Journal of chromatography. A.

[72]  K. Row,et al.  Effect of Ionic Liquids as the Mobile Phase Additives on the HPLC Resolution of Four Active Compounds from Sophora flavescens Ait , 2009, Molecules.

[73]  Daijie Wang,et al.  Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae. , 2009, Journal of separation science.

[74]  D. Armstrong,et al.  Solvent properties of the 1-butyl-3-methylimidazolium hexafluorophosphate ionic liquid , 2003, Analytical and bioanalytical chemistry.

[75]  T. Jiang,et al.  Dynamically coating the capillary with 1-alkyl-3-methylimidazolium-based ionic liquids for separation of basic proteins by capillary electrophoresis , 2003 .

[76]  Yi He,et al.  Preparation of ionic liquid based solid-phase microextraction fiber and its application to forensic determination of methamphetamine and amphetamine in human urine. , 2009, Journal of chromatography. A.

[77]  Wei-Ting Wang,et al.  Using subcritical/supercritical fluid chromatography to separate acidic, basic, and neutral compounds over an ionic liquid-functionalized stationary phase. , 2009, Journal of chromatography. A.

[78]  Lijun He,et al.  Ionic liquid-based dispersive liquid-liquid microextraction followed high-performance liquid chromatography for the determination of organophosphorus pesticides in water sample. , 2009, Analytica chimica acta.

[79]  Hao Chen,et al.  Separation and preconcentration system based on ultrasonic probe-assisted ionic liquid dispersive liquid-liquid microextraction for determination trace amount of chromium(VI) by electrothermal atomic absorption spectrometry. , 2010, Talanta.

[80]  R. Cela,et al.  Development of an ionic liquid based dispersive liquid-liquid microextraction method for the analysis of polycyclic aromatic hydrocarbons in water samples. , 2009, Journal of chromatography. A.

[81]  H. Qiu,et al.  Preparation and evaluation of a silica-based 1-alkyl-3-(propyl-3-sulfonate) imidazolium zwitterionic stationary phase for high-performance liquid chromatography. , 2007, Journal of chromatography. A.

[82]  Paul Scovazzo,et al.  Determination of the upper limits, benchmarks, and critical properties for gas separations using stabilized room temperature ionic liquid membranes (SILMs) for the purpose of guiding future research , 2009 .

[83]  J. Crespo,et al.  Highly selective transport of organic compounds by using supported liquid membranes based on ionic liquids. , 2002, Angewandte Chemie.

[84]  K. R. Seddon.  Ionic Liquids for Clean Technology , 1997 .

[85]  Xiao-hua Xiao,et al.  Application of ionic liquids in the microwave-assisted extraction of trans-resveratrol from Rhizma Polygoni Cuspidati. , 2007, Journal of chromatography. A.

[86]  G. Zweig,et al.  Determination of organophosphorus pesticides in water. , 1969, Residue reviews.

[87]  R. P. Swatloski,et al.  Task-specific ionic liquids for the extraction of metal ions from aqueous solutions , 2001 .

[88]  Jianji Wang,et al.  Recovery of Furfural from Aqueous Solution by Ionic Liquid Based Liquid–Liquid Extraction , 2008 .

[89]  M. Matsumoto,et al.  Comparison of solvent extraction and supported liquid membrane permeation using an ionic liquid for concentrating penicillin G , 2007 .

[90]  H. Ohno,et al.  Amino acid ionic liquids. , 2007, Accounts of chemical research.

[91]  Hongyuan Yan,et al.  Solid-Phase Extraction of Caffeine and Theophylline from Green Tea by a New Ionic Liquid-Modified Functional Polymer Sorbent , 2009 .

[92]  Q. Wei,et al.  A new room temperature ionic liquid 1-butyl-3-trimethylsilylimidazolium hexafluorophosphate as a solvent for extraction and preconcentration of mercury with determination by cold vapor atomic absorption spectrometry. , 2007, Talanta.

[93]  Jared L. Anderson,et al.  Polymeric ionic liquids as selective coatings for the extraction of esters using solid-phase microextraction. , 2008, Journal of chromatography. A.

[94]  L. Yuan,et al.  (R)‐N,N,N‐Trimethyl‐2‐Aminobutanol‐Bis(Trifluoromethane‐Sulfon)Imidate Chiral Ionic Liquid Used as Chiral Selector in HPCE, HPLC, and CGC , 2006 .

[95]  M. Borissova,et al.  Micellar electrophoresis using ionic liquids. , 2008, Journal of chromatography. A.

[96]  M Valcárcel,et al.  Determination of phenothiazine derivatives in human urine by using ionic liquid-based dynamic liquid-phase microextraction coupled with liquid chromatography. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[97]  M. Akhond,et al.  Extraction and high performance liquid chromatographic determination of 3-indole butyric acid in pea plants by using imidazolium-based ionic liquids as extractant. , 2008, Talanta.

[98]  Jason E. Bara,et al.  Improving CO2 permeability in polymerized room‐temperature ionic liquid gas separation membranes through the formation of a solid composite with a room‐temperature ionic liquid , 2008 .

[99]  W. Bi,et al.  Solid-phase extraction of liquiritin and glycyrrhizic acid from licorice using ionic liquid-based silica sorbent. , 2009, Journal of separation science.

[100]  A. Yu,et al.  Microwave extraction of essential oils from dried fruits of Illicium verum Hook. f. and Cuminum cyminum L. using ionic liquid as the microwave absorption medium. , 2009, Journal of separation science.

[101]  A. Stalcup,et al.  Characterization of a novel pyridinium bromide surface confined ionic liquid stationary phase for high-performance liquid chromatography under normal phase conditions via linear solvation energy relationships. , 2008, Journal of chromatography. A.

[102]  H. Bai,et al.  Enrichment and sensitive determination of dichlorodiphenyltrichloroethane and its metabolites with temperature controlled ionic liquid dispersive liquid phase microextraction prior to high performance liquid phase chromatography. , 2009, Analytica chimica acta.

[103]  H. Abdolmohammad-Zadeh,et al.  A novel microextraction technique based on 1-hexylpyridinium hexafluorophosphate ionic liquid for the preconcentration of zinc in water and milk samples. , 2009, Analytica chimica acta.

[104]  L. Mondello,et al.  Conventional and fast gas chromatography analysis of biodiesel blends using an ionic liquid stationary phase. , 2009, Journal of chromatography. A.

[105]  Hideto Matsuyama,et al.  CO2 separation facilitated by task-specific ionic liquids using a supported liquid membrane , 2008 .

[106]  G. Jiang,et al.  Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles. , 2008, Talanta.

[107]  A. Berthod,et al.  Ionic liquids versus triethylamine as mobile phase additives in the analysis of beta-blockers. , 2006, Journal of chromatography. A.

[108]  A. Stalcup,et al.  Mobile phase effects on retention on a new butylimidazolium-based high-performance liquid chromatographic stationary phase. , 2006, Journal of chromatography. A.

[109]  Yan Zhu,et al.  Ionic liquids extraction of Para Red and Sudan dyes from chilli powder, chilli oil and food additive combined with high performance liquid chromatography. , 2009, Analytica chimica acta.

[110]  Miguel Valcárcel,et al.  Combined use of carbon nanotubes and ionic liquid to improve the determination of antidepressants in urine samples by liquid chromatography , 2008, Analytical and bioanalytical chemistry.