Osteocytes, mechanosensing and Wnt signaling.
暂无分享,去创建一个
[1] David L. Paul,et al. Beyond the gap: functions of unpaired connexon channels , 2003, Nature Reviews Molecular Cell Biology.
[2] Clinton T. Rubin,et al. Regulation of bone mass by mechanical strain magnitude , 1985, Calcified Tissue International.
[3] Mark L. Johnson,et al. Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone* , 2006, Journal of Biological Chemistry.
[4] J. Graff,et al. Casein kinase I transduces Wnt signals , 1999, Nature.
[5] L. Bonewald,et al. Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. , 2005, Molecular biology of the cell.
[6] Mark L. Johnson,et al. The gene for high bone mass , 2002 .
[7] A. Parfitt,et al. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. , 1998, The Journal of clinical investigation.
[8] A. van der Plas,et al. Sensitivity of osteocytes to biomechanical stress in vitro , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[9] Xi Jiang,et al. Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. , 2004, Bone.
[10] Stephen E. Harris,et al. E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation , 2006, Molecular and Cellular Biology.
[11] Y. Mikuni‐Takagaki,et al. Matrix mineralization and the differentiation of osteocyte‐like cells in culture , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[12] P. Niederer,et al. In vivo tracer transport through the lacunocanalicular system of rat bone in an environment devoid of mechanical loading. , 1998, Bone.
[13] M. Balooch,et al. Glucocorticoid‐Treated Mice Have Localized Changes in Trabecular Bone Material Properties and Osteocyte Lacunar Size That Are Not Observed in Placebo‐Treated or Estrogen‐Deficient Mice , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[14] P. Nijweide,et al. Identification of osteocytes in osteoblast-like cell cultures using a monoclonal antibody specifically directed against osteocytes , 2004, Histochemistry.
[15] Christof Niehrs,et al. Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling , 2002, Nature.
[16] H Clevers,et al. The chromatin remodelling factor Brg‐1 interacts with β‐catenin to promote target gene activation , 2001, The EMBO journal.
[17] J. Currey. The many adaptations of bone. , 2003, Journal of biomechanics.
[18] J. Williams,et al. Effects of fluid shear stress on bone cells. , 1994, Biorheology.
[19] H. Varmus,et al. Casein kinase 2 associates with and phosphorylates Dishevelled , 1997, The EMBO journal.
[20] L. Lanyon. Osteocytes, strain detection, bone modeling and remodeling , 2005, Calcified Tissue International.
[21] D. Alessi,et al. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis , 2005, The EMBO journal.
[22] G. Oster,et al. Mechanical aspects of mesenchymal morphogenesis. , 1983, Journal of embryology and experimental morphology.
[23] P. ten Dijke,et al. SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. , 2005, Cytokine & growth factor reviews.
[24] C. Kaufmann,et al. Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization , 1999, The Journal of cell biology.
[25] L. Bonewald,et al. PGE(2) is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain. , 2001, Endocrinology.
[26] S. Cowin,et al. Fluid pressure relaxation depends upon osteonal microstructure: modeling an oscillatory bending experiment. , 1999, Journal of biomechanics.
[27] Stephen C. Cowin,et al. Modeling Tracer Transport in an Osteon under Cyclic Loading , 2004, Annals of Biomedical Engineering.
[28] D. Davy,et al. Machine vision photogrammetry: a technique for measurement of microstructural strain in cortical bone. , 2001, Journal of biomechanics.
[29] J. Frangos,et al. Alkaline phosphatase in osteoblasts is down-regulated by pulsatile fluid flow , 2009, Calcified Tissue International.
[30] L. Bonewald,et al. Establishment of an Osteocyte‐like Cell Line, MLO‐Y4 , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[31] Peng Liu,et al. Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling* , 2005, Journal of Biological Chemistry.
[32] J. McGarry,et al. The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts. , 2005, Biochemical and biophysical research communications.
[33] M. Kühl,et al. Kinases and G proteins join the Wnt receptor complex , 2006, BioEssays : news and reviews in molecular, cellular and developmental biology.
[34] J. Woodgett,et al. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[35] Jason W. Triplett,et al. Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles , 2007, Journal of cellular biochemistry.
[36] J. A. Robinson,et al. High Bone Mass in Mice Expressing a Mutant LRP5 Gene , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[37] S. Fukumoto,et al. Akt Participation in the Wnt Signaling Pathway through Dishevelled* , 2001, The Journal of Biological Chemistry.
[38] Jörg Stappert,et al. β‐catenin is a target for the ubiquitin–proteasome pathway , 1997 .
[39] T. Takano-Yamamoto,et al. A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy. , 2001, Bone.
[40] R. Baron,et al. Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[41] R. Moon,et al. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. , 2000, Trends in genetics : TIG.
[42] Eric J. Anderson,et al. Nano–Microscale Models of Periosteocytic Flow Show Differences in Stresses Imparted to Cell Body and Processes , 2005, Annals of Biomedical Engineering.
[43] L. Bonewald,et al. Tissue strain amplification at the osteocyte lacuna: a microstructural finite element analysis. , 2007, Journal of biomechanics.
[44] P. Niederer,et al. A finite element analysis for the prediction of load-induced fluid flow and mechanochemical transduction in bone. , 2003, Journal of theoretical biology.
[45] H. Frost. Bone “mass” and the “mechanostat”: A proposal , 1987, The Anatomical record.
[46] C. Milgrom,et al. Stress fractures , 1991, The American journal of sports medicine.
[47] K. Druey,et al. Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis , 2005, Science.
[48] D. Ginty,et al. Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins , 2005, Nature.
[49] Richard P Lifton,et al. High bone density due to a mutation in LDL-receptor-related protein 5. , 2002, The New England journal of medicine.
[50] Marek Mlodzik,et al. Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? , 2002, Trends in genetics : TIG.
[51] A. Robling,et al. The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone Response to Parathyroid Hormone Treatment* , 2006, Journal of Biological Chemistry.
[52] Daniel P Nicolella,et al. Osteocyte lacunae tissue strain in cortical bone. , 2006, Journal of biomechanics.
[53] S. Sokol,et al. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin , 1998, Current Biology.
[54] Shiqin Zhang,et al. Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression* , 2006, Journal of Biological Chemistry.
[55] Sheldon Weinbaum,et al. On bone adaptation due to venous stasis. , 2003, Journal of biomechanics.
[56] H J Donahue,et al. Differential effect of steady versus oscillating flow on bone cells. , 1998, Journal of biomechanics.
[57] S. Cowin,et al. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. , 1994, Journal of biomechanics.
[58] Melissa L. Knothe Tate. Mixing Mechanisms and Net Solute Transport in Bone , 2004, Annals of Biomedical Engineering.
[59] Kosaku Kurata,et al. Bone Marrow Cell Differentiation Induced by Mechanically Damaged Osteocytes in 3D Gel‐Embedded Culture , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[60] G. Evan,et al. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis , 2002, The Journal of cell biology.
[61] Mark L. Johnson,et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. , 2002, American journal of human genetics.
[62] L. Lanyon,et al. Regulation of bone formation by applied dynamic loads. , 1984, The Journal of bone and joint surgery. American volume.
[63] T. Hentunen,et al. Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts. , 2004, Experimental cell research.
[64] Caiying Guo,et al. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation , 2005, Nature Genetics.
[65] William C. Skarnes,et al. An LDL-receptor-related protein mediates Wnt signalling in mice , 2000, Nature.
[66] Akira Kikuchi,et al. Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3β and β-Catenin and Inhibits Axis Formation ofXenopus Embryos , 1998, Molecular and Cellular Biology.
[67] Akira Kikuchi,et al. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin , 1998 .
[68] Christof Niehrs,et al. Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction , 2005, Nature.
[69] Alison Rowe,et al. Wise, a context-dependent activator and inhibitor of Wnt signalling , 2003, Development.
[70] J. Bidwell,et al. Fluid Shear Stress Induces β-Catenin Signaling in Osteoblasts , 2004, Calcified Tissue International.
[71] Christof Niehrs,et al. Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation , 2007, Science.
[72] W. Birchmeier,et al. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. , 1998, Science.
[73] K. Lau,et al. Up-regulation of the Wnt, Estrogen Receptor, Insulin-like Growth Factor-I, and Bone Morphogenetic Protein Pathways in C57BL/6J Osteoblasts as Opposed to C3H/HeJ Osteoblasts in Part Contributes to the Differential Anabolic Response to Fluid Shear* , 2006, Journal of Biological Chemistry.
[74] L. Williams,et al. Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription , 1998 .
[75] Y. Mikuni‐Takagaki,et al. Distinct responses of different populations of bone cells to mechanical stress. , 1996, Endocrinology.
[76] L. Bonewald,et al. Expression of Functional Gap Junctions and Regulation by Fluid Flow in Osteocyte‐Like MLO‐Y4 Cells , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[77] J. Frangos,et al. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production , 1990, Journal of cellular physiology.
[78] D. Burr,et al. Effects of biomechanical stress on bones in animals. , 2002, Bone.
[79] E. Fuchs,et al. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. , 1999, Development.
[80] J. Westendorf,et al. Wnt signaling in osteoblasts and bone diseases. , 2004, Gene.
[81] L. Lanyon,et al. Mechanical Strain and Bone Cell Function: A Review , 2002, Osteoporosis International.
[82] O. J. Whittemore,et al. Vitamin D-enhanced osteocytic and osteoclastic bone resorption. , 1973, The American journal of physiology.
[83] E. Wieschaus,et al. Regulation of Armadillo by a Drosophila APC Inhibits Neuronal Apoptosis during Retinal Development , 1998, Cell.
[84] Sunil Wadhwa,et al. Fluid Flow Induction of Cyclo‐Oxygenase 2 Gene Expression in Osteoblasts Is Dependent on an Extracellular Signal‐Regulated Kinase Signaling Pathway , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[85] L E Lanyon,et al. Loading‐related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling? , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[86] K. Lindpaintner,et al. Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease , 2002, Journal of medical genetics.
[87] Paul Polakis,et al. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β , 1998, Current Biology.
[88] T. Takano-Yamamoto,et al. Fluid Shear Stress Induces Less Calcium Response in a Single Primary Osteocyte Than in a Single Osteoblast: Implication of Different Focal Adhesion Formation , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[89] K. Metsikkö,et al. Isolated primary osteocytes express functional gap junctions in vitro , 2006, Cell and Tissue Research.
[90] M. Quintanilla,et al. Induction of PA2.26, a cell‐surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis , 1997, Molecular carcinogenesis.
[91] L. Lanyon,et al. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. , 1996, Bone.
[92] P. Nijweide,et al. Biochemical and histological studies on various bone cell preparations , 2006, Calcified Tissue International.
[93] L. Bonewald,et al. MLO‐Y4 Osteocyte‐Like Cells Support Osteoclast Formation and Activation , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[94] D. M. Ferkey,et al. Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification , 2000, The Journal of cell biology.
[95] Minqi Li,et al. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. , 2007, Cell metabolism.
[96] S. Lovestone,et al. GSK3α exhibits β‐catenin and tau directed kinase activities that are modulated by Wnt , 2006 .
[97] H. Ozawa,et al. Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered , 2004, Journal of Bone and Mineral Metabolism.
[98] Sheldon Weinbaum,et al. Mechanotransduction and strain amplification in osteocyte cell processes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[99] M Dioszegi,et al. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). , 2001, Human molecular genetics.
[100] S. Manolagas,et al. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. , 2000, Endocrine reviews.
[101] Minrong Ai,et al. Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling , 2005, Molecular and Cellular Biology.
[102] Daisuke Mizuno,et al. Bio Imaging of Intracellular NO Production in Single Bone Cells After Mechanical Stimulation , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[103] Scott Saunders,et al. Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[104] T. Akiyama,et al. Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level , 1998, Genes to cells : devoted to molecular & cellular mechanisms.
[105] Yuh Nung Jan,et al. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling , 2001, Nature Cell Biology.
[106] Miikka Vikkula,et al. LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development , 2001, Cell.
[107] L. Bonewald,et al. Mechanosensation and Transduction in Osteocytes. , 2006, BoneKEy osteovision.
[108] M M Newhouse,et al. Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. , 1996, Genes & development.
[109] D. Salter,et al. CD44 expression in human bone: A novel marker of osteocytic differentiation , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[110] Sunil Wadhwa,et al. Fluid flow induces COX-2 expression in MC3T3-E1 osteoblasts via a PKA signaling pathway. , 2002, Biochemical and biophysical research communications.
[111] S. Sokol,et al. Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins , 2002, Molecular and Cellular Biology.
[112] H. Vrieling,et al. Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP‐Stimulated Bone Formation , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[113] C. Hartmann. A Wnt canon orchestrating osteoblastogenesis. , 2006, Trends in cell biology.
[114] B. Komm,et al. Wnt signaling and osteoblastogenesis , 2007, Reviews in Endocrine and Metabolic Disorders.
[115] Ron Y Kwon,et al. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism , 2007, Proceedings of the National Academy of Sciences.
[116] Jing Zhou,et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells , 2003, Nature Genetics.
[117] Hendrik C Korswagen,et al. Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling , 2005, Science.