Covalent binding of polychlorinated biphenyls to rat liver microsomes in vitro: nature of reactive metabolites and target macromolecules.

[1]  B. Preston,et al.  Direct evidence that an arene oxide is a metabolic intermediate of 2,2',5,5'-tetrachlorobiphenyl. , 1979, Biochemical and biophysical research communications.

[2]  H. Matthews,et al.  In vivo binding of 2,3,6,2',3',6'-hexachlorobiphenyl and 2,4,5,2',4',5'-hexachlorobiphenyl to mouse liver macromolecules. , 1979, Chemico-biological interactions.

[3]  T. Shimada,et al.  Inhibition of mono-oxygenase activities by 1,1,1-trichloropropene 2,3-oxide, an inhibitor of epoxide hydrase, in rat liver microsomes. , 1979, Biochemical pharmacology.

[4]  S. Safe,et al.  4-chlorobiphenyl metabolism: the effects of chemical inducers. , 1979, General pharmacology.

[5]  K. Enomoto,et al.  Nature of tryptic attack on cytochrome b5 and further evidence for the two-domain structure of the cytochrome molecule. , 1978, Journal of biochemistry.

[6]  T. Wolff,et al.  Activation of [14C] chlorobiphenyls to protein-binding metabolites by rat liver microsomes. , 1978, Chemico-biological interactions.

[7]  Sato Ryo,et al.  Covalent binding in vitro of polychlorinated biphenyls to microsomal macromolecules. Involvement of metabolic activation by a cytochrome P-450-linked mono-oxygenase system. , 1978 .

[8]  P. Thomas,et al.  Properties of purified liver microsomal cytochrome P450 from rats treated with the polychlorinated biphenyl mixture Aroclor 1254. , 1977, Molecular pharmacology.

[9]  G. Dallner,et al.  Enzyme and phospholipid asymmetry in liver microsomal membranes , 1977, The Journal of cell biology.

[10]  S. Safe,et al.  The in vitro metabolism, macromolecular binding and bacterial mutagenicity of 4-chloribiphenyl, a model PCB substrate. , 1976, Research communications in chemical pathology and pharmacology.

[11]  J. L. Seymour,et al.  In Vitro Generation of a Chemically Reactive Metabolite of 2,5,2′,5′-Tetrachlorobiphenyl by Rhesus Monkey Liver Microsomes , 1976, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[12]  Y. Imai The use of 8-aminooctyl sepharose for the separation of some components of the hepatic microsomal electron transfer system. , 1976, Journal of biochemistry.

[13]  H. Matthews,et al.  Metabolism of 2,4,5,2',5'-pentachlorobiphenyl in the rat. Qualitative and quantitative aspects. , 1976, Drug metabolism and disposition: the biological fate of chemicals.

[14]  T. Shimada Metabolic activation of [14C] polychlorinated biphenyl mixtures by rat liver microsomes , 1976, Bulletin of environmental contamination and toxicology.

[15]  O. Hutzinger,et al.  The metabolism of chlorobiphenyls — A review , 1976 .

[16]  J. Depierre,et al.  Structural aspects of the membrane of the endoplasmic reticulum. , 1975, Biochimica et biophysica acta.

[17]  H. Gelboin,et al.  Aryl hydrocarbon (benzo[a]pyrene) hydroxylases in liver from rats of different age, sex and nutritional status. Distinction of two types by 7,8-benzoflavone. , 1975, Biochemical pharmacology.

[18]  Jerry R. Mitchell,et al.  Metabolic Activation of Drugs to Toxic Substances , 1975 .

[19]  H. Vainio Enhancement of microsomal drug oxidation and glucuronidation in rat liver by an environmental chemical, polychlorinated biphenyl. , 1974, Chemico-biological interactions.

[20]  B. Brodie,et al.  Biochemical Mechanisms of Drug Toxicity , 1974 .

[21]  D. Jollow,et al.  Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. , 1974, Pharmacology.

[22]  J. T. Chen,et al.  Polychlorinated biphenyls: hydroxylated urinary metabolites of 2,5,2',5'-tetrachlorobiphenyl identified in rabbits. , 1973, Biochemical and biophysical research communications.

[23]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. , 1973, The Journal of pharmacology and experimental therapeutics.

[24]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. , 1973, The Journal of pharmacology and experimental therapeutics.

[25]  J. Allen,et al.  Morphological and biochemical changes in the liver of rats fed polychlorinated biphenyls , 1973, Archives of environmental contamination and toxicology.

[26]  F. Oesch,et al.  Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds. , 1973, Xenobiotica; the fate of foreign compounds in biological systems.

[27]  D. Bickers,et al.  Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[28]  J. Vos,et al.  Comparative toxicity study of 2,4,5,2',4',5'-hexachlorobiphenyl and a polychlorinated biphenyl mixture in rabbits. , 1972, Toxicology and applied pharmacology.

[29]  D. Nebert,et al.  Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. , 1972, Molecular pharmacology.

[30]  R. Kimbrough,et al.  Morphological changes in livers of rats fed polychlorinated biphenyls: light microscopy and ultrastructure. , 1972, Archives of environmental health.

[31]  K. Mihara,et al.  Partial purification of NADH-cytochrome b 5 reductase from rabbit liver microsomes with detergents and its properties. , 1972, Journal of biochemistry.

[32]  M. Nishizumi Light and electron microscope study of chlorobiphenyl poisoning. In mouse and monkey liver. , 1970, Archives of environmental health.

[33]  T. Omura,et al.  A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes. , 1970, Journal of biochemistry.

[34]  A. Ito,et al.  PROTEOLYTIC MICRODISSECTION OF SMOOTH-SURFACED VESICLES OF LIVER MICROSOMES , 1969, The Journal of cell biology.

[35]  T. Omura,et al.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES. , 1964, The Journal of biological chemistry.

[36]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.