The helical hydrophobic moment avoids prolines in phospholipid-binding proteins.

Proline residues appear to punctuate the distribution of amphiphilic phospholipid-binding regions of apolipoproteins. We have applied a quantitative test to this hypothesis and shown that the magnitude of the helical hydrophobic moment around proline residues is reduced in lipid-binding proteins and peptides.

[1]  D. Eisenberg,et al.  Analysis of membrane and surface protein sequences with the hydrophobic moment plot. , 1984, Journal of molecular biology.

[2]  David Eisenberg,et al.  The helical hydrophobic moment: a measure of the amphiphilicity of a helix , 1982, Nature.

[3]  M. Levitt.  A simplified representation of protein conformations for rapid simulation of protein folding. , 1976, Journal of molecular biology.

[4]  A. Gotto,et al.  Lipid-protein interactions in the plasma lipoproteins. , 1977, Biochimica et biophysica acta.

[5]  A. Gotto,et al.  A molecular theory of lipid—protein interactions in the plasma lipoproteins , 1974, FEBS letters.

[6]  J. B. Massey,et al.  Helical amphipathic moment: application to plasma lipoproteins , 1983 .

[7]  J. Vater,et al.  Amino-acid sequence of the large subunit of d-ribulosebisphosphate carboxylase/oxygenase from Nicotiana tabacum , 1983 .

[8]  P. Y. Chou,et al.  Empirical predictions of protein conformation. , 1978, Annual review of biochemistry.

[9]  A. Catapano,et al.  Phospholipids and Atherosclerosis , 1983 .

[10]  J. B. Massey,et al.  Lateral distribution of phospholipid and cholesterol in apolipoprotein A-I recombinants. , 1985, Biochemistry.

[11]  D. Russell,et al.  The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA , 1984, Cell.

[12]  C. Tanford,et al.  The solubility of amino acids and two glycine peptides in aqueous ethanol and dioxane solutions. Establishment of a hydrophobicity scale. , 1971, The Journal of biological chemistry.

[13]  M. Phillips,et al.  The helical hydrophobic moments and surface activities of serum apolipoproteins. , 1983, Biochimica et biophysica acta.