Early Response of the Canine Respiratory Tract Following Long-Term Exposure to a Sulfur(IV) Aerosol at Low Concentration. I. Rationale, Design, Methodology, and Summary

AbstractThe present study was designed to investigate the effect of chronic inhalation of a low concentration of airborne sulfur(IV) on mammalian lungs. Eight beagle dogs were continuously exposed in whole-body chambers for 290 d to a respirable S(IV) aerosol with a mass median aerodynamic diameter of 0.6 µm (geometric standard deviation about 2) at a concentration of 0.3 mg m−3, equivalent to a sulfur dioxide concentration of 0.6 mg m−3. Three dogs served as sentinels.To establish baseline data for lung parameters, the dogs were first housed in the chambers for 400 d under clean air conditions. Biochemical and cellular parameters in the lung lavage fluids were evaluated repeatedly for each dog. During exposure, each lung parameter was again measured repeatedly for each dog and the values obtained were compared with the baseline values. Thus each individual served as its own control. Parameters of respiratory lung function and lung morphology were only evaluated at the end of the study The three sentinal ...

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