Engineering allostery.
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Srivatsan Raman | George M Church | Stanley Fields | G. Church | S. Fields | Srivatsan Raman | N. Taylor | Noah Taylor | Naomi Genuth | Naomi R. Genuth
[1] J. Devito. Recombineering with tolC as a Selectable/Counter-selectable Marker: remodeling the rRNA Operons of Escherichia coli , 2007, Nucleic acids research.
[2] David Baker,et al. Computational design of ligand-binding proteins with high affinity and selectivity , 2013, Nature.
[3] Timothy A. Whitehead,et al. Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing , 2012, Nature Biotechnology.
[4] D. Lawrence,et al. Biosensors of protein kinase action: from in vitro assays to living cells. , 2004, Biochimica et biophysica acta.
[5] Huiming Ding,et al. Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics , 2014, Proceedings of the National Academy of Sciences.
[6] K. Yamamoto,et al. A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90. , 2007, Journal of molecular biology.
[7] M. Lewis,et al. The lac repressor. , 2005, Comptes rendus biologies.
[8] J H Miller,et al. Genetic studies of the lac repressor. XIII. Extensive amino acid replacements generated by the use of natural and synthetic nonsense suppressors. , 1990, Journal of molecular biology.
[9] CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor. , 2014, Biochemical and biophysical research communications.
[10] Liskin Swint-Kruse,et al. Perturbation from a distance: mutations that alter LacI function through long-range effects. , 2003, Biochemistry.
[11] James J. Collins,et al. Next-Generation Synthetic Gene Networks , 2009, Nature Biotechnology.
[12] May C Morris,et al. Fluorescent biosensors - probing protein kinase function in cancer and drug discovery. , 2013, Biochimica et biophysica acta.
[13] M. Lewis,et al. A closer view of the conformation of the Lac repressor bound to operator , 2000, Nature Structural Biology.
[14] K. Matthews,et al. Flexibility in the inducer binding region is crucial for allostery in the Escherichia coli lactose repressor. , 2009, Biochemistry.
[15] Nathaniel J. Traaseth,et al. Allosteric cooperativity in protein kinase A , 2008, Proceedings of the National Academy of Sciences.
[16] R. Tsien,et al. Circular permutation and receptor insertion within green fluorescent proteins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[17] Jay D Keasling,et al. Transcription factor-based screens and synthetic selections for microbial small-molecule biosynthesis. , 2013, ACS synthetic biology.
[18] L. Swint-Kruse,et al. Multiple Co-Evolutionary Networks Are Supported by the Common Tertiary Scaffold of the LacI/GalR Proteins , 2012, PloS one.
[19] Michael Y. Galperin. Structural Classification of Bacterial Response Regulators: Diversity of Output Domains and Domain Combinations , 2006, Journal of bacteriology.
[20] F. J. Poelwijk,et al. The spatial architecture of protein function and adaptation , 2012, Nature.
[21] Jeffrey M. Skerker,et al. Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways , 2010, PLoS genetics.
[22] William Bourguet,et al. A canonical structure for the ligand-binding domain of nuclear receptors , 1996, Nature Structural Biology.
[23] Rommie E. Amaro,et al. A network of conserved interactions regulates the allosteric signal in a glutamine amidotransferase. , 2007, Biochemistry.
[24] K. Fujishige,et al. Robust in vitro affinity maturation strategy based on interface-focused high-throughput mutational scanning. , 2012, Biochemical and biophysical research communications.
[25] B. Müller-Hill,et al. The side-chain of the amino acid residue in position 110 of the Lac repressor influences its allosteric equilibrium. , 1996, Journal of molecular biology.
[26] S. Freund,et al. An ensemble view of thrombin allostery , 2012, Biological chemistry.
[27] Jeffrey J. Gray,et al. Contact rearrangements form coupled networks from local motions in allosteric proteins , 2008, Proteins.
[28] Jay Shendure,et al. Saturation Editing of Genomic Regions by Multiplex Homology-Directed Repair , 2014, Nature.
[29] Olivier Lichtarge,et al. Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors , 2010, Proceedings of the National Academy of Sciences.
[30] F. S. Mathews,et al. Structural identification of the pathway of long-range communication in an allosteric enzyme , 2008, Proceedings of the National Academy of Sciences.
[31] K. Nishikawa,et al. Parallel evolution of ligand specificity between LacI/GalR family repressors and periplasmic sugar-binding proteins. , 2003, Molecular biology and evolution.
[32] N. Goodey,et al. Allosteric regulation and catalysis emerge via a common route. , 2008, Nature chemical biology.
[33] D. Baker,et al. High Resolution Mapping of Protein Sequence–Function Relationships , 2010, Nature Methods.
[34] M. Caron,et al. Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization , 1996, Science.
[35] Sriram Kosuri,et al. Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips , 2010, Nature Biotechnology.
[36] S. Fields,et al. A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function , 2012, Proceedings of the National Academy of Sciences.
[37] M. Palmer,et al. Cell-Based High-Throughput Screening Assay System for Monitoring G Protein-Coupled Receptor Activation Using β-Galactosidase Enzyme Complementation Technology , 2002, Journal of biomolecular screening.
[38] Jeffrey Miller,et al. Genetic Studies of Lac Repressor: 4000 Single Amino Acid Substitutions and Analysis of the Resulting Phenotypes on the Basis of the Protein Structure , 1996, German Conference on Bioinformatics.
[39] Marc Ostermeier,et al. Directed evolution of protein switches and their application to the creation of ligand-binding proteins. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[40] Farren J. Isaacs,et al. Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement , 2011, Science.
[41] Vincent Laudet,et al. Principles for modulation of the nuclear receptor superfamily , 2004, Nature Reviews Drug Discovery.
[42] S. Fields,et al. Deep mutational scanning: a new style of protein science , 2014, Nature Methods.
[43] Alfonso Valencia,et al. Emerging methods in protein co-evolution , 2013 .
[44] J. Schlessinger,et al. Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.
[45] Dan V. Nicolau,et al. Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch , 2010, Science.
[46] Rama Ranganathan,et al. Structural Determinants of Allosteric Ligand Activation in RXR Heterodimers , 2004, Cell.
[47] J. Tavernier,et al. Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System , 2012, Microbiology and Molecular Reviews.
[48] J. A. González-Vera. Probing the Kinome in Real Time with Fluorescent Peptides , 2012 .
[49] James O. Wrabl,et al. Structural and energetic basis of allostery. , 2012, Annual review of biophysics.
[50] Joseph B Hiatt,et al. Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis , 2013, Proceedings of the National Academy of Sciences.
[51] Tony Pawson,et al. The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells , 2014, Nature Methods.
[52] Gary D. Bader,et al. Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing. , 2010, Molecular bioSystems.