Anatomical Congruence of Metabolic and Electromagnetic Activation Signals during a Self-Paced Motor Task: A Combined PET–MEG Study

We have investigated the degree of spatial correlation between the cerebral blood flow variations measured by positron emission tomography (PET) and the electromagnetic sources as measured by magnetoencephalography (MEG) in five subjects while performing a self-paced right index finger tapping task. Data were processed independently for each technique using both single-case and intersubject analysis. PET and MEG were coregistered with anatomical magnetic resonance images for each subject. Both extension and flexion motor-related fields were extracted from the MEG signal. Using the single dipole model we identified the motor evoked field 1 (MEF1) in all subjects and the motor field (MF) in three subjects. Individual and intersubject averaged PET data showed consistent contralateral primary sensorimotor (PSM) hand area and bilateral supplementary motor area activation. MEG individual and intersubject averaged results demonstrated that both MEF1 and MF dipoles were localized within the PSM PET activated area. Individual PSM mass center to dipole distance was 12 and 15.3 mm on average for the MEF1 and the MF component, respectively. For the same components, the intersubject averaged analysis shows distances between the PET Z-score maximum and the dipole locations of 6.3 and 15.0 mm, respectively. These results show that PET and MEG MEF1 activation signals spatially coincide within instrumental, registration, and modeling errors.

[1]  P. Roland,et al.  Regional cerebral blood flow changes in cortex and basal ganglia during voluntary movements in normal human volunteers. , 1982, Journal of neurophysiology.

[2]  Riitta Hari,et al.  Cerebral magnetic fields associated with voluntary limb movements in man , 1983 .

[3]  W. T. Thach,et al.  Functional mapping of the human cerebellum with positron emission tomography. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Risto J. Ilmoniemi.  Neuromagnetism: Theory, techniques, and measurements , 1985 .

[5]  R J Ilmoniemi,et al.  Cerebral magnetic fields. , 1986, Critical reviews in biomedical engineering.

[6]  J. Sarvas.  Basic mathematical and electromagnetic concepts of the biomagnetic inverse problem. , 1987, Physics in medicine and biology.

[7]  R. Hari,et al.  Spatial resolution of neuromagnetic records: theoretical calculations in a spherical model. , 1988, Electroencephalography and clinical neurophysiology.

[8]  H Shibasaki,et al.  Recording of movement-related potentials from scalp and cortex in man. , 1988, Brain : a journal of neurology.

[9]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[10]  J. Jaffe,et al.  Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine-dependent rat. , 1990, Neuroreport.

[11]  D. Cohen,et al.  MEG versus EEG localization test using implanted sources in the human brain , 1990, Annals of neurology.

[12]  S. Stone-Elander,et al.  Motor learning in man: a positron emission tomographic study. , 1990, Neuroreport.

[13]  L. Deecke.  Electrophysiological correlates of movement initiation. , 1990, Revue neurologique.

[14]  Christian Bohm,et al.  Somatosensory Discrimination of Shape: Tactile Exploration and Cerebral Activation , 1991, The European journal of neuroscience.

[15]  Karl J. Friston,et al.  Regional cerebral blood flow during voluntary arm and hand movements in human subjects. , 1991, Journal of neurophysiology.

[16]  C Tomberg,et al.  Reaction times recording methods: reliability and EMG analysis of patterns of motor commands. , 1991, Electroencephalography and clinical neurophysiology.

[17]  L. Deecke,et al.  Neuromagnetic fields accompanying unilateral and bilateral voluntary movements: topography and analysis of cortical sources. , 1991, Electroencephalography and clinical neurophysiology.

[18]  L. Deecke,et al.  Homuncular organization of human motor cortex as indicated by neuromagnetic recordings , 1991, Neuroscience Letters.

[19]  R. Trebossen,et al.  Physical characteristics of the ECAT 953B/31: a new high resolution brain positron tomograph , 1991 .

[20]  H Shibasaki,et al.  Invasive Recording of Movement‐Related Cortical Potentials in Humans , 1992, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[21]  Scott T. Grafton,et al.  Human functional anatomy of visually guided finger movements. , 1992, Brain : a journal of neurology.

[22]  J. Mazziotta,et al.  Rapid Automated Algorithm for Aligning and Reslicing PET Images , 1992, Journal of computer assisted tomography.

[23]  M. Honda,et al.  Both primary motor cortex and supplementary motor area play an important role in complex finger movement. , 1993, Brain : a journal of neurology.

[24]  R D Bucholz,et al.  Magnetic source imaging: a review of the Magnes system of biomagnetic technologies incorporated. , 1993, Neurosurgery.

[25]  R. Ilmoniemi,et al.  Magnetoencephalography-theory, instrumentation, and applications to noninvasive studies of the working human brain , 1993 .

[26]  David F. Sobel,et al.  Noninvasive presurgical neuromagnetic mapping of somatosensory cortex. , 1993, Neurosurgery.

[27]  A. Syrota,et al.  The Cortical Representation of Speech , 1993, Journal of Cognitive Neuroscience.

[28]  J. Mazziotta,et al.  MRI‐PET Registration with Automated Algorithm , 1993, Journal of computer assisted tomography.

[29]  R. Hari,et al.  Functional Organization of the Human First and Second Somatosensory Cortices: a Neuromagnetic Study , 1993, The European journal of neuroscience.

[30]  U Sabatini,et al.  Journal of Cerebral Blood Flow and Metabolism Effect of Side and Rate of Stimulation on Cerebral Blood Flow Changes in Motor Areas during Finger Movements in Humans , 2022 .

[31]  M. Raichle,et al.  Tactile-vibration-activated foci in insular and parietal-opercular cortex studied with positron emission tomography: mapping the second somatosensory area in humans. , 1993, Somatosensory & motor research.

[32]  A L Benabid,et al.  Functional MRI of the human brain: predominance of signals from extracerebral veins. , 1994, Neuroreport.

[33]  O Levrier,et al.  Location of hand function in the sensorimotor cortex: MR and functional correlation. , 1994, AJNR. American journal of neuroradiology.

[34]  J. Tanji.  The supplementary motor area in the cerebral cortex , 1994, Neuroscience Research.

[35]  M. Gazzaniga,et al.  Combined spatial and temporal imaging of brain activity during visual selective attention in humans , 1994, Nature.

[36]  Y. Samson,et al.  Movement‐ and task‐related activations of motor cortical areas: A positron emission tomographic study , 1994, Annals of neurology.

[37]  D. Brooks,et al.  Motor sequence learning: a study with positron emission tomography , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[38]  C Pantev,et al.  Comparison of magnetic, and metabolic brain activity during a verb generation task , 1994, Neuroreport.

[39]  B Lütkenhöner,et al.  A Neuromagnetic Study of the Functional Organization of the Sensorimotor Cortex , 1994, The European journal of neuroscience.

[40]  M Requardt,et al.  Functional cooperativity of human cortical motor areas during self-paced simple finger movements. A high-resolution MRI study. , 1994, Brain : a journal of neurology.

[41]  Karl J. Friston,et al.  Statistical parametric maps in functional imaging: A general linear approach , 1994 .

[42]  I. Tarkka,et al.  Electrical source localization of human movement-related cortical potentials. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[43]  Isabelle Bloch,et al.  Fast Nonsupervised 3D Registration of PET and MR Images of the Brain , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[44]  C C Wood,et al.  Mapping function in the human brain with magnetoencephalography, anatomical magnetic resonance imaging, and functional magnetic resonance imaging. , 1995, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[45]  Karl J. Friston,et al.  Spatial registration and normalization of images , 1995 .

[46]  H. Weinberg,et al.  Motor cortex activity and predicting side of movement: neural network and dipole analysis of pre-movement magnetic fields , 1995, Neuroscience Letters.

[47]  C. Marsden,et al.  Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects. , 1995, Brain : a journal of neurology.

[48]  P. Roland,et al.  Somatosensory Activations of the Parietal Operculum of Man. A PET Study , 1995, The European journal of neuroscience.

[49]  J. Donoghue,et al.  Shared neural substrates controlling hand movements in human motor cortex. , 1995, Science.

[50]  E Moser,et al.  Comparing Localization of Conventional Functional Magnetic Resonance Imaging and Magnetoencephalography , 1995, The European journal of neuroscience.

[51]  C. Svarer,et al.  Rate Dependence of Regional Cerebral Activation during Performance of a Repetitive Motor Task: A PET Study , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[52]  J. Lewine,et al.  Comparison of primary motor cortex localization using functional magnetic resonance imaging and magnetoencephalography , 1996, Human brain mapping.

[53]  W G Tatton,et al.  Contributions of the mesial frontal cortex to the premovement potentials associated with intermittent hand movements in humans , 1996, Human brain mapping.

[54]  W Lang,et al.  Generation of movement-related potentials and fields in the supplementary sensorimotor area and the primary motor area. , 1996, Advances in neurology.

[55]  B. Mazoyer,et al.  Use of anatomical parcellation to catalog and study structure‐function relationships in the human brain , 1997, Human brain mapping.

[56]  B. Renault,et al.  Functional Anatomy of Human Auditory Attention Studied with PET , 1997, NeuroImage.

[57]  H. Alkadhi,et al.  Localization of the motor hand area to a knob on the precentral gyrus. A new landmark. , 1997, Brain : a journal of neurology.