Sequential chromatogram ratio technique: evaluation of the effects of retention time precision, adsorption isotherm linearity, and detector linearity on qualitative and quantitative analysis

A study of the sequential chromatogram ration technique was done to characterized and correct for retention time variation, peak-shape change due to concentraions exceeding the adsorption isotherm linear range, and mild detector nonlinearty over a broad concentration range. A sensitive minimization routine was developed to overlay chromatographic peaks from sequential injections using a simple displacement along the time axis

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