Metabolomics of Genetically Modified Crops

Metabolomic-based approaches are increasingly applied to analyse genetically modified organisms (GMOs) making it possible to obtain broader and deeper information on the composition of GMOs compared to that obtained from traditional analytical approaches. The combination in metabolomics of advanced analytical methods and bioinformatics tools provides wide chemical compositional data that contributes to corroborate (or not) the substantial equivalence and occurrence of unintended changes resulting from genetic transformation. This review provides insight into recent progress in metabolomics studies on transgenic crops focusing mainly in papers published in the last decade.

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[71]  Patrik Rydén,et al.  OnPLS integration of transcriptomic, proteomic and metabolomic data shows multi-level oxidative stress responses in the cambium of transgenic hipI- superoxide dismutase Populus plants , 2013, BMC Genomics.

[72]  Daniel Raftery,et al.  Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics , 2007, Analytical and bioanalytical chemistry.

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[75]  D. Ohta,et al.  Metabolic profiling of transgenic potato tubers expressing Arabidopsis dehydration response element-binding protein 1A (DREB1A). , 2013, Journal of agricultural and food chemistry.

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[85]  M. J. Nozal,et al.  Use of supercritical fluid extraction and gas chromatography-mass spectrometry to obtain amino acid profiles from several genetically modified varieties of maize and soybean. , 2008, Journal of chromatography. A.

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[87]  Andrew R. Jakubowski,et al.  Assessing metabolomic and chemical diversity of a soybean lineage representing 35 years of breeding , 2014, Metabolomics.

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[91]  P. Schmitt‐Kopplin,et al.  Evaluation of glycoalkaloids in tubers of genetically modified virus Y-resistant potato plants (var. Désirée) by non-aqueous capillary electrophoresis coupled with electrospray ionization mass spectrometry (NACE–ESI–MS) , 2003, Analytical and bioanalytical chemistry.

[92]  Kazuki Saito,et al.  Covering Chemical Diversity of Genetically-Modified Tomatoes Using Metabolomics for Objective Substantial Equivalence Assessment , 2011, PloS one.

[93]  K. Engel,et al.  Metabolite profiling of maize kernels--genetic modification versus environmental influence. , 2012, Journal of agricultural and food chemistry.

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