CONSTRUCTION OF THE HCV-HEPATOCYTE SYSTEM MODEL

*SUMMARY Motivation: the hepatites С is one of the most dangerous diseases of the human and there are no effective medical products. Overwhelming majority of cases of disease pass in a chronic stage (Racanelli, Rehermann, 2003). For creation of new vaccines and medical products detailed studying life cycle of a virus and revealing of the factors influencing its reproduction and protein synthesis is necessary. As research of behaviour HCV in vitro is complicated, creation of computer model of a genetic network infected HCV hepatocyte and its use for the experimental analysis is expedient. Results: the mathematical model of the hepatites C virus evolution in the hepatocyte has been developed. Model allows estimate concentration of various components of the system virus-cell: DNA, RNA, proteins, virus particles and other components eventually. The model assumes consideration discrete time intervals, within number of various chemical and biological reactions, possible at presence, is maximized. The problem of creation of adequate model consists that many parameters of model are unknown. Therefore the primary goal of the given work was the selection of parameters of model and demonstration of its correctness for simple cases of behaviour of system a virus-hepatocyte.