An overview on synthetic and biological activities of cannabidiol (CBD) and its derivatives.
暂无分享,去创建一个
Lixia Chen | Yang Xu | Hua Li | Yan Liu | Xiuli Wang | Bingyou Yang | Huan Zhang | Huanbang Zhang
[1] Jirong Luo,et al. Enantioselective Total Synthesis of Cannabinoids via a Tandem Conjugate Addition/Enolate Alkylation Annulation with Ambiphilic Organoboronates. , 2023, Organic letters.
[2] J. Muscat,et al. Inhibition of Nicotine Metabolism by Cannabidiol (CBD) and 7-Hydroxycannabidiol (7-OH-CBD) , 2023, Chemical research in toxicology.
[3] Qi Wu,et al. 8,9-Dihydrocannabidiol, an Alternative of Cannabidiol, Its Preparation, Antibacterial and Antioxidant Ability , 2023, Molecules.
[4] P. Trivedi,et al. Selective CB2 Receptor Agonist, HU-308, Reduces Systemic Inflammation in Endotoxin Model of Pneumonia-Induced Acute Lung Injury , 2022, International journal of molecular sciences.
[5] C. Bladen,et al. The anticonvulsant phytocannabinoids CBGVA and CBDVA inhibit recombinant T-type channels , 2022, Frontiers in Pharmacology.
[6] K. Lovell,et al. Synthesis and Inhibitory Activity of Machaeridiol-Based Novel Anti-MRSA and Anti-VRE Compounds and Their Profiling for Cancer-Related Signaling Pathways , 2022, Molecules.
[7] Z. Liu,et al. New cannabidiol (CBD) derivatives: Synthesis, anti-inflammatory activity, and molecular docking , 2022, Phytochemistry Letters.
[8] D. Passarella,et al. Stereoselective Synthetic Strategies to (−)‐Cannabidiol , 2022, ChemistrySelect.
[9] M. McDonnell,et al. Anti-Inflammatory Properties of KLS-13019: a Novel GPR55 Antagonist for Dorsal Root Ganglion and Hippocampal Cultures , 2022, Journal of Molecular Neuroscience.
[10] R. Pertwee,et al. Motor-like Tics are Mediated by CB2 Cannabinoid Receptor-dependent and Independent Mechanisms Associated with Age and Sex , 2022, Molecular Neurobiology.
[11] E. Denovan‐Wright,et al. Synthetic cannabinoids reduce the inflammatory activity of microglia and subsequently improve neuronal survival in vitro , 2022, Brain, Behavior, and Immunity.
[12] Shiyu Jin,et al. Pharmacological Activation of GPR55 Improved Cognitive Impairment Induced by Lipopolysaccharide in Mice , 2022, Journal of Molecular Neuroscience.
[13] L. Lo Presti,et al. Total Synthesis of (‐)‐Cannabidiol‐C4 , 2022, European Journal of Organic Chemistry.
[14] Rui Yu,et al. The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice , 2022, Neurobiology of Disease.
[15] R. Vishwakarma,et al. Stereoselective Synthesis of Nonpsychotic Natural Cannabidiol and Its Unnatural/Terpenyl/Tail-Modified Analogues. , 2022, The Journal of organic chemistry.
[16] D. Meltzer,et al. Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. , 2022, Science advances.
[17] P. Basu,et al. Autism and associated disorders: cannabis as a potential therapy. , 2022, Frontiers in bioscience.
[18] Shiyu Jin,et al. Activation of GPR55 attenuates cognitive impairment, oxidative stress, neuroinflammation, and synaptic dysfunction in a streptozotocin-induced Alzheimer's mouse model , 2022, Pharmacology Biochemistry and Behavior.
[19] F. Guimarães,et al. The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPARγ Receptors , 2021, Neurotherapeutics.
[20] S. Romero-Zerbo,et al. Abnormal cannabidiol ameliorates inflammation preserving pancreatic beta cells in mouse models of experimental type 1 diabetes and beta cell damage. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[21] R. Enciso,et al. Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis , 2021, Journal of dental anesthesia and pain medicine.
[22] G. Appendino,et al. EHP-101 alleviates angiotensin II-induced fibrosis and inflammation in mice. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[23] Shiyu Jin,et al. Activation of GPR55 attenuates cognitive impairment and neurotoxicity in a mouse model of Alzheimer's disease induced by Aβ1–42 through inhibiting RhoA/ROCK2 pathway , 2021, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[24] Dong Fu,et al. Cytochrome P450–Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol , 2021, Drug Metabolism and Disposition.
[25] R. Mechoulam,et al. Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats , 2021, Journal of Cannabis Research.
[26] G. Appendino,et al. Cannabinoquinones: Synthesis and Biological Profile , 2021, Biomolecules.
[27] A. Rolland,et al. Neuroprotection with the Cannabidiol Quinone Derivative VCE-004.8 (EHP-101) against 6-Hydroxydopamine in Cell and Murine Models of Parkinson’s Disease , 2021, Molecules.
[28] B. Fiebich,et al. (+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB1R antagonist/CB2R agonist that prevents diabetic nephropathy in mice. , 2021, Pharmacological research.
[29] M. Elsohly,et al. Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis , 2021, Molecules.
[30] D. Brenneman,et al. Behavioural and pharmacological effects of cannabidiol (CBD) and the cannabidiol analogue KLS‐13019 in mouse models of pain and reinforcement , 2021, British journal of pharmacology.
[31] R. Mechoulam,et al. Cannabinoid Quinones—A Review and Novel Observations , 2021, Molecules.
[32] Kwang-Hyeon Liu,et al. O-1602 Promotes Hepatic Steatosis through GPR55 and PI3 Kinase/Akt/SREBP-1c Signaling in Mice , 2021, International journal of molecular sciences.
[33] A. Ramazani,et al. A review on the syntheses of Dronabinol and Epidiolex as classical cannabinoids with various biological activities including those against SARS-COV2 , 2021, Journal of the Iranian Chemical Society.
[34] P. Allegrini,et al. A Novel and Practical Continuous Flow Chemical Synthesis of Cannabidiol (CBD) and its CBDV and CBDB Analogues , 2021 .
[35] L. Pazdera,et al. A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures , 2021, Cannabis and cannabinoid research.
[36] F. O. Holguin,et al. Using (+)-Carvone to access novel derivatives of (+)-ent-Cannabidiol: the first asymmetric syntheses of (+)-ent-CBDP and (+)-ent-CBDV. , 2021, Tetrahedron letters.
[37] I. McGregor,et al. Determining the magnitude and duration of acute Δ9-tetrahydrocannabinol (Δ9-THC)-induced driving and cognitive impairment: A systematic and meta-analytic review , 2021, Neuroscience & Biobehavioral Reviews.
[38] R. Marks,et al. The effect of cannabis toxicity on a model microbiome bacterium epitomized by a panel of bioluminescent E. coli. , 2021, Chemosphere.
[39] M. Beenhakker,et al. Cannabidiolic acid exhibits entourage-like improvements of anticonvulsant activity in an acute rat model of seizures , 2020, Epilepsy Research.
[40] G. Gigli,et al. Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol , 2020, Scientific Reports.
[41] L. Devi,et al. Diversity of molecular targets and signaling pathways for CBD , 2020, Pharmacology research & perspectives.
[42] J. Manzanares,et al. Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression, and Psychotic Disorders , 2020, Biomolecules.
[43] D. Vigli,et al. Chronic Treatment with Cannabidiolic Acid (CBDA) Reduces Thermal Pain Sensitivity in Male Mice and Rescues the Hyperalgesia in a Mouse Model of Rett Syndrome , 2020, Neuroscience.
[44] A. McAinch,et al. The Role of Atypical Cannabinoid Ligands O-1602 and O-1918 on Skeletal Muscle Homeostasis with a Focus on Obesity , 2020, International journal of molecular sciences.
[45] Eduardo Orrego-González,et al. Cannabinoid Effects on Experimental Colorectal Cancer Models Reduce Aberrant Crypt Foci (ACF) and Tumor Volume: A Systematic Review , 2020, Evidence-based complementary and alternative medicine : eCAM.
[46] L. Fusar-Poli,et al. Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies , 2020, Brain sciences.
[47] D. Ulrich,et al. O-1602, an Agonist of Atypical Cannabinoid Receptors GPR55, Reverses the Symptoms of Depression and Detrusor Overactivity in Rats Subjected to Corticosterone Treatment , 2020, Frontiers in Pharmacology.
[48] C. Svensson. CBD for the treatment of pain: What is the evidence? , 2020, Journal of the American Pharmacists Association : JAPhA.
[49] P. Radziszewski,et al. The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis. , 2020, European journal of pharmacology.
[50] O. Valverde,et al. BEHAVIOURAL AND MOLECULAR EFFECTS OF CANNABIDIOLIC ACID IN MICE , 2020, bioRxiv.
[51] M. Pirrung. Synthetic Access to Cannabidiol and Analogs As Active Pharmaceutical Ingredients. , 2020, Journal of medicinal chemistry.
[52] M. Catauro,et al. (‒)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research , 2020, Molecules.
[53] N. Teixeira,et al. Cannabis sativa: much more beyond Δ9-tetrahydrocannabinol. , 2020, Pharmacological research.
[54] S. Romero-Zerbo,et al. The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease , 2020, Frontiers in Endocrinology.
[55] Chengyuan Liang,et al. Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease. , 2020, European journal of medicinal chemistry.
[56] S. Petrosino,et al. Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets. , 2020, Biochemical pharmacology.
[57] B. Vissel,et al. Targeting the cannabinoid receptor CB2 in a mouse model of l-dopa induced dyskinesia , 2020, Neurobiology of Disease.
[58] R. Urman,et al. The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence , 2020, Current Pain and Headache Reports.
[59] L. Mestre,et al. Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis , 2020, Neurobiology of Disease.
[60] F. Dehghani,et al. Abnormal Cannabidiol Affects Production of Pro-Inflammatory Mediators and Astrocyte Wound Closure in Primary Astrocytic-Microglial Cocultures , 2020, Molecules.
[61] H. Aisa,et al. Synthesis of CBD and Its Derivatives Bearing Various C4'-side Chains with a Late-Stage Diversification Method. , 2019, The Journal of organic chemistry.
[62] R. Mechoulam,et al. Sleep and neurochemical modulation by cannabidiolic acid methyl ester in rats , 2019, Brain Research Bulletin.
[63] HuiChao Wang,et al. Effects of O‐1602 and CBD on TNBS‐induced colonic disturbances , 2019, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
[64] G. Gigli,et al. A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol , 2019, Scientific Reports.
[65] L. Degenhardt,et al. Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis. , 2019, The lancet. Psychiatry.
[66] I. Choi,et al. Synthetic Strategies for (-)-Cannabidiol and Its Structural Analogs. , 2019, Chemistry, an Asian journal.
[67] J. Achenbach,et al. Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer , 2019, Front. Pharmacol..
[68] R. Capasso,et al. The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients. , 2019, Pharmacological research.
[69] G. Gigli,et al. Chemical and spectroscopic characterization data of ‘cannabidibutol’, a novel cannabidiol butyl analog , 2019, Data in brief.
[70] S. Bonaccorso,et al. Cannabidiol (CBD) use in psychiatric disorders: A systematic. , 2019, Neurotoxicology.
[71] Y. Kwan,et al. G-protein coupled receptor 55 agonists increase insulin secretion through inositol trisphosphate-mediated calcium release in pancreatic β-cells. , 2019, European journal of pharmacology.
[72] M. Dallas,et al. Synthetic, non-intoxicating 8,9-dihydrocannabidiol for the mitigation of seizures , 2019, Scientific Reports.
[73] D. Brenneman,et al. Knockdown siRNA Targeting the Mitochondrial Sodium-Calcium Exchanger-1 Inhibits the Protective Effects of Two Cannabinoids Against Acute Paclitaxel Toxicity , 2019, Journal of Molecular Neuroscience.
[74] J. Fernández-Ruiz,et al. Targeting glial cannabinoid CB2 receptors to delay the progression of the pathological phenotype in TDP‐43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis , 2019, British journal of pharmacology.
[75] P. Forcelli,et al. Preclinical safety and efficacy of cannabidivarin for early life seizures , 2019, Neuropharmacology.
[76] Y. Kwan,et al. Novel protective effect of O-1602 and abnormal cannabidiol, GPR55 agonists, on ER stress-induced apoptosis in pancreatic β-cells. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[77] G. Appendino,et al. Cannabinoid derivatives acting as dual PPAR&ggr;/CB2 agonists as therapeutic agents for systemic sclerosis , 2019, Biochemical pharmacology.
[78] F. Guimarães,et al. DMH‐CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF‐kB activity dependent on A2A receptor , 2019, Toxicology and applied pharmacology.
[79] A. McAinch,et al. Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity , 2019, Endocrine connections.
[80] M. Baciut,et al. Cannabinoids and bone regeneration , 2019, Drug metabolism reviews.
[81] Z. Song,et al. Novel inverse agonists for the orphan G protein-coupled receptor 6 , 2018, Heliyon.
[82] G. Appendino,et al. EHP‐101, an oral formulation of the cannabidiol aminoquinone VCE‐004.8, alleviates bleomycin‐induced skin and lung fibrosis , 2018, Biochemical pharmacology.
[83] M. J. Vazquez,et al. VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity , 2018, Scientific Reports.
[84] F. Guimarães,et al. Neuronal preservation and reactive gliosis attenuation following neonatal sciatic nerve axotomy by a fluorinated cannabidiol derivative , 2018, Neuropharmacology.
[85] C. Raggi,et al. Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome , 2018, Neuropharmacology.
[86] G. Appendino,et al. VCE‐004.3, a cannabidiol aminoquinone derivative, prevents bleomycin‐induced skin fibrosis and inflammation through PPARγ‐ and CB2 receptor‐dependent pathways , 2018, British journal of pharmacology.
[87] D. Brenneman,et al. Pharmacological Comparisons Between Cannabidiol and KLS-13019 , 2018, Journal of Molecular Neuroscience.
[88] Barry N. Dungan,et al. Lewis-Acid-Mediated Union of Epoxy-Carvone Diastereomers with Anisole Derivatives: Mechanistic Insight and Application to the Synthesis of Non-natural CBD Analogues. , 2018, Organic letters.
[89] S. Giofrè,et al. Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol. , 2018, Fitoterapia.
[90] F. Mach,et al. The quest for endothelial atypical cannabinoid receptor: BKCa channels act as cellular sensors for cannabinoids in in vitro and in situ endothelial cells. , 2018, Vascular pharmacology.
[91] G. Heeba,et al. Abnormal cannabidiol confers cardioprotection in diabetic rats independent of glycemic control , 2018, European journal of pharmacology.
[92] D. Thapa,et al. The Cannabinoids Δ8THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation , 2018, Cannabis and cannabinoid research.
[93] J. Jacobson,et al. Enantioselective Total Synthesis of Cannabinoids-A Route for Analogue Development. , 2018, Organic letters.
[94] C. Limebeer,et al. Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5‐HT1A receptor‐mediated suppression of nausea and anxiety in rats , 2018, British journal of pharmacology.
[95] M. Balíková,et al. Pharmacokinetic and behavioural profile of THC, CBD, and THC+CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of conversion in vivo of CBD to THC , 2017, European Neuropsychopharmacology.
[96] F. Guimarães,et al. Antinociceptive effects of HUF-101, a fluorinated cannabidiol derivative , 2017, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[97] C. Müller,et al. GPR55: A therapeutic target for Parkinson's disease? , 2017, Neuropharmacology.
[98] T. Bíró,et al. 460 Assessment of the anti-inflammatory effects of fluorinated semi-synthetic phytocannabinoids in human in vitro inflammatory keratinocyte model systems , 2017 .
[99] E. Chow,et al. A selective review of medical cannabis in cancer pain management. , 2017, Annals of palliative medicine.
[100] P. Morales,et al. An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol , 2017, Front. Pharmacol..
[101] D. Friedman,et al. Pharmacology of cannabinoids in the treatment of epilepsy , 2017, Epilepsy & Behavior.
[102] C. Limebeer,et al. Cannabinoid 2 (CB2) receptor agonism reduces lithium chloride-induced vomiting in Suncus murinus and nausea-induced conditioned gaping in rats. , 2016, European journal of pharmacology.
[103] Regina M. Krohn,et al. Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment , 2016, Journal of Inflammation.
[104] F. Guimarães,et al. Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects , 2016, PloS one.
[105] J. Elverdín,et al. Anti-Inflammatory and Osteoprotective Effects of Cannabinoid-2 Receptor Agonist HU-308 in a Rat Model of Lipopolysaccharide-Induced Periodontitis. , 2016, Journal of periodontology.
[106] Z. Vogel,et al. Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells , 2016, Journal of basic and clinical physiology and pharmacology.
[107] G. Appendino,et al. The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways , 2016, Scientific Reports.
[108] Tao Qian,et al. Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability. , 2016, ACS medicinal chemistry letters.
[109] Z. Vogel,et al. HU‐446 and HU‐465, Derivatives of the Non‐psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells , 2016, Chemical biology & drug design.
[110] H. Aramaki,et al. Cannabidiol-2',6'-dimethyl ether stimulates body weight gain in apolipoprotein E-deficient BALB/c. KOR/Stm Slc-Apoe(shl) mice. , 2015, The Journal of toxicological sciences.
[111] M. Feldmann,et al. HU-444, a Novel, Potent Anti-Inflammatory, Nonpsychotropic Cannabinoid , 2015, The Journal of Pharmacology and Experimental Therapeutics.
[112] M. Dallas,et al. Molecular Targets of Cannabidiol in Neurological Disorders , 2015, Neurotherapeutics.
[113] M. Cascio,et al. CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency , 2015, Proceedings of the National Academy of Sciences.
[114] D. Su,et al. Activation of cannabinoid receptor 2 attenuates synovitis and joint distruction in collagen-induced arthritis. , 2015, Immunobiology.
[115] S. Mercer,et al. HU-331 is a catalytic inhibitor of topoisomerase IIα. , 2014, Chemical research in toxicology.
[116] H. Aramaki,et al. Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells. , 2014, The Journal of toxicological sciences.
[117] R. Bergman,et al. Obesity, insulin resistance and comorbidities? Mechanisms of association. , 2014, Arquivos brasileiros de endocrinologia e metabologia.
[118] E. Brǎiloiu,et al. Activation of GPR18 by cannabinoid compounds: a tale of biased agonism , 2014, British journal of pharmacology.
[119] Dao-Yi Yu,et al. Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature. , 2014, European journal of pharmacology.
[120] S. Yamaori,et al. Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. , 2014, Chemico-biological interactions.
[121] P. Hazelton,et al. Prospects for cannabinoid therapies in viral encephalitis , 2013, Brain Research.
[122] E. Rock,et al. Suppression of lithium chloride-induced conditioned gaping (a model of nausea-induced behaviour) in rats (using the taste reactivity test) with metoclopramide is enhanced by cannabidiolic acid , 2013, Pharmacology Biochemistry and Behavior.
[123] Makoto Tsunozaki,et al. TRPA1: A gatekeeper for inflammation. , 2013, Annual review of physiology.
[124] Shane M. Wilkinson,et al. Improved accessibility to the desoxy analogues of Δ9-tetrahydrocannabinol and cannabidiol , 2013 .
[125] F. Guimarães,et al. Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors. , 2012, Journal of psychiatric research.
[126] Akhilesh Kumar,et al. Involvement of a non-CB1/CB2 cannabinoid receptor in the aqueous humor outflow-enhancing effects of abnormal-cannabidiol. , 2012, Experimental eye research.
[127] M. Neurath,et al. TRPA1 and substance P mediate colitis in mice. , 2011, Gastroenterology.
[128] K. Mackie,et al. The atypical cannabinoid O‐1602 protects against experimental colitis and inhibits neutrophil recruitment , 2011, Inflammatory bowel diseases.
[129] T. Bisogno,et al. Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes , 2011, British journal of pharmacology.
[130] Y. Fukunishi,et al. Cannabidiol-2',6'-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro. , 2011, Biological & pharmaceutical bulletin.
[131] J. McDougall,et al. The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55 , 2011, Neuroscience Letters.
[132] H. Qian,et al. Activation of cannabinoid receptor CB2 regulates osteogenic and osteoclastogenic gene expression in human periodontal ligament cells. , 2010, Journal of periodontal research.
[133] R. Capasso,et al. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. , 2009, Trends in pharmacological sciences.
[134] K. Mackie,et al. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo , 2009, Proceedings of the National Academy of Sciences.
[135] I. Yamamoto,et al. Cannabidiol-2′,6′-Dimethyl Ether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor , 2009, Drug Metabolism and Disposition.
[136] L. Steardo,et al. Cannabidiol: A Promising Drug for Neurodegenerative Disorders? , 2009, CNS neuroscience & therapeutics.
[137] A. Deiters,et al. A cyclotrimerization route to cannabinoids. , 2008, Organic letters.
[138] R. Pertwee,et al. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin , 2008 .
[139] Pál Pacher,et al. Pivotal Advance: Cannabinoid‐2 receptor agonist HU‐308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis , 2007 .
[140] S. Dowell,et al. The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects , 2007, British journal of pharmacology.
[141] F. Diederich,et al. Fluorine in Pharmaceuticals: Looking Beyond Intuition , 2007, Science.
[142] S. Nikas,et al. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. , 2007, Journal of medicinal chemistry.
[143] R. Mechoulam,et al. A Cannabinoid Anticancer Quinone, HU-331, Is More Potent and Less Cardiotoxic Than Doxorubicin: A Comparative in Vivo Study , 2007, Journal of Pharmacology and Experimental Therapeutics.
[144] S. Morimoto,et al. Cannabidiolic‐acid synthase, the chemotype‐determining enzyme in the fiber‐type Cannabis sativa , 2007, FEBS letters.
[145] Jiyue Zheng,et al. A general route to 5,6-seco-hexahydrodibenzopyrans and analogues: first total synthesis of (+)-Machaeridiol B and (+)-Machaeriol B , 2007 .
[146] M. Guzmán,et al. A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells , 2006, Molecular Pharmacology.
[147] A. Takeuchi,et al. Synthesis of cannabidiols via alkenylation of cyclohexenyl monoacetate. , 2006, Organic letters.
[148] S. Ben-Shabat,et al. New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity. , 2006, Journal of medicinal chemistry.
[149] M. Elsohly,et al. Chemical constituents of marijuana: the complex mixture of natural cannabinoids. , 2005, Life sciences.
[150] D. Ponde,et al. Peripheral, but not central effects of cannabidiol derivatives: Mediation by CB1 and unidentified receptors , 2005, Neuropharmacology.
[151] Raphael Mechoulam,et al. Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors. , 2005, Organic & biomolecular chemistry.
[152] D. Gibson,et al. Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. , 2004, Journal of medicinal chemistry.
[153] G. Kunos,et al. Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. , 2004, European journal of pharmacology.
[154] M. Feldmann,et al. A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. , 2004, Arthritis and rheumatism.
[155] B. Tekwani,et al. Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorum. , 2003, Journal of natural products.
[156] R. Mechoulam,et al. Synthesis of a primary metabolite of cannabidiol. , 2000, Organic letters.
[157] R. Mechoulam. Looking back at Cannabis research. , 2000, Current pharmaceutical design.
[158] Lei Wang,et al. Cardiovascular effects of endocannabinoids--the plot thickens. , 2000, Prostaglandins & other lipid mediators.
[159] R. Mechoulam,et al. HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[160] I. Yamamoto,et al. Synthesis and pharmacological evaluation in mice of halogenated cannabidiol derivatives. , 1999, Chemical & pharmaceutical bulletin.
[161] I. Yamamoto,et al. Synthesis and pharmacological activities in mice of halogenated delta 9-tetrahydrocannabinol derivatives. , 1998, Chemical & pharmaceutical bulletin.
[162] R. Pertwee,et al. The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor. , 1995, Life sciences.
[163] I. Yamamoto,et al. Synthesis and pharmacological effects in mice of halogenated cannabinol derivatives. , 1995, Chemical & pharmaceutical bulletin.
[164] M. Correia,et al. Characterization of cannabidiol-mediated cytochrome P450 inactivation. , 1993, Biochemical pharmacology.
[165] V. Vaillancourt,et al. A One‐Step Method for the α‐Arylation of Camphor. Synthesis of (‐ )‐Cannabidiol and (+)‐Cannabidiol Dimethyl Ether. , 1992 .
[166] K. Albizati,et al. A one-step method for the .alpha.-arylation of camphor. Synthesis of (-)-cannabidiol and (-)-cannabidiol dimethyl ether. , 1992 .
[167] I. Yamamoto,et al. Cannabielsoin as a new metabolite of cannabidiol in mammals , 1991, Pharmacology Biochemistry and Behavior.
[168] A. Hiltunen,et al. Enantiomeric cannabinoids: stereospecificity of psychotropic activity , 1988, Experientia.
[169] L. Crombie,et al. Terpenylations Using (R)‐(‐)‐α‐Phellandrene. Synthesis of the (3S,4R)‐8,9‐Dihydro‐o‐ and ‐p‐cannabidiols, Their iso‐THC′s, and the Natural Dihydrochalcone (3S,4R)‐(+)‐Linderatin. , 1988 .
[170] K. Tamao,et al. (Diisopropoxymethylsilyl)methyl Grignard reagent: a new, practically useful nucleophilic hydroxymethylating agent , 1983 .
[171] C. Bercht,et al. CANNABINODIOL- CONCLUSIVE IDENTIFICATION AND SYNTHESIS OF A NEW CANNABINOID FROM CANNABIS SATIVA , 1977 .
[172] R. Razdan,et al. HASHISH PART 10, A SIMPLE ONE-STEP SYNTHESIS OF (-)-DELTA(1)-TETRAHYDROCANNABINOL (THC) FROM P-MENTHA-2,8-DIEN-1-OL AND OLIVETOL , 1974 .
[173] E. R. Garrett,et al. Physicochemical Properties, Solubility, and Protein Binding of Δ9 -Tetrahydrocannabinol , 1974 .
[174] S. Servi,et al. Alkylation of resorcinols with monoterpenoid allylic alcohols in aqueous acid. Synthesis of new cannabinoid derivatives , 1973 .
[175] R. Mechoulam,et al. The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish. , 1971, Journal of the American Chemical Society.
[176] R. Mechoulam,et al. A TOTAL SYNTHESIS OF DL-DELTA-1-TETRAHYDROCANNABINOL, THE ACTIVE CONSTITUENT OF HASHISH. , 1965, Journal of the American Chemical Society.
[177] R. Adams,et al. Structure of Cannabinol. III. Synthesis of Cannabinol, 1-Hydroxy-3-n-amyl-6,6,9-trimethyl-6-dibenzopyran1 , 1940 .
[178] J. Marcu,et al. Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. , 2017, Advances in pharmacology.
[179] S. Yamaori,et al. Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. , 2013, Drug metabolism and pharmacokinetics.
[180] Shuso Takeda. [Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis]. , 2013, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
[181] N. Kitteringham,et al. Metabolism of fluorine-containing drugs. , 2001, Annual review of pharmacology and toxicology.
[182] Raphael Mechoulam,et al. Synthesis of the individual, pharmacologically distinct, enantiomers of a tetrahydrocannabinol derivative , 1990 .
[183] T. Umemoto,et al. N-fluoropyridinium triflate and its derivatives: useful fluorinating agents , 1986 .
[184] J. Leite,et al. Anticonvulsant effects of the (-) and (+)isomers of cannabidiol and their dimethylheptyl homologs. , 1982, Pharmacology.
[185] R. Mechoulam,et al. Carboxylation of resorcinols with methylmagnesium carbonate. Synthesis of cannabinoid acids , 1969 .
[186] T. Petrzilka,et al. Synthese von Haschisch-Inhaltsstoffen. 4. Mitteilung , 1969 .
[187] R. Mechoulam,et al. The ISO‐Tetrahydrocannabinols , 1968 .
[188] A. Eschenmoser,et al. Synthese und Chiralität des (-)-Cannabidiols Vorläufige Mitteilung , 1967 .
[189] R. Mechoulam,et al. Hashish. IV. The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acids. , 1965, Tetrahedron.