Differences in growth and morphology between the spontaneous C3H mammary carcinoma in the mouse and its syngeneic transplants

The rate of growth of the C3H spontaneous mammary carcinoma in the mouse was compared with that of its first and 900th generation (C3HBA) syngeneic transplants. The microscopic appearance, change in relative volume of tissues, and relation of blood vessels to the tumor nodules were compared in the 3 tumors. The initial rate of growth and the retardation which subsequently occurred increased with transplantation. The relative volume of cancer cells decreased and necrosis increased with tumor growth in each of the tumors; the change was least in the spontaneous tumor and increased with transplantation. Blood vessels were confined to the internodular tissues in the transplants but were also present within the nodules in the spontaneous tumor. The results stress the importance of blood supply in determining retardation in the rate of tumor growth. It also emphasizes the care that should be taken in selecting an animal tumor model that simulates the human tumor, when the results are applied to the treatment of cancer in patients.

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