Different profiles of anthropogenic and naturally produced organohalogen compounds in serum from residents living near a coastal area and e-waste recycling workers in India.

We determined the contamination status and accumulation profiles of polychlorinated biphenyls (PCBs), hydroxylated PCB congeners (OH-PCBs), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), methoxylated PBDEs (MeO-PBDEs), and bromophenols (BPhs) in serum from e-waste recycling workers and residents near a coastal area in India. Residue levels of penta- to octa-chlorinated PCBs, penta- to octa-chlorinated OH-PCBs, 6MeO-BDE47, 6OH-BDE47, and 2,4,6-tri-BPh in serum from residents living near the coastal area were significantly higher than those in serum from e-waste recycling workers. Residue levels of tri- to tetra-chlorinated PCBs, tri- to tetra-chlorinated OH-PCBs, PBDEs, octa-brominated OH-PBDEs, and tetra-BPhs in serum from e-waste recycling workers were higher than those in serum from residents living near the coastal area. Principal component analysis revealed that residents living near the coastal area and e-waste recycling workers had different serum profiles of chlorinated and brominated compounds.

[1]  J. Kissel,et al.  Uncertainty in estimated half-lives of PCBS in humans: impact on exposure assessment. , 1996, The Science of the total environment.

[2]  S. Safe,et al.  Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin. , 1993, Chemico-biological interactions.

[3]  Eva Jakobsson,et al.  Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers. , 1999 .

[4]  G. Marsh,et al.  Identification of hydroxylated polybrominated diphenyl ether metabolites in blood plasma from polybrominated diphenyl ether exposed rats. , 2005, Environmental science & technology.

[5]  G. Marsh,et al.  Identification of hydroxylated and methoxylated polybrominated diphenyl ethers in Baltic Sea salmon (Salmo salar) blood. , 2004, Environmental science & technology.

[6]  F. Helidoniotis,et al.  Distribution of Bromophenols in Australian Wild-Harvested and Cultivated Prawns (Shrimp) , 1997 .

[7]  Mari Ochiai,et al.  Anthropogenic and naturally occurring polybrominated phenolic compounds in the blood of cetaceans stranded along Japanese coastal waters. , 2011, Environmental pollution.

[8]  J. McLachlan,et al.  Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. , 1999, Environmental health perspectives.

[9]  P. Ayotte,et al.  Analysis of hydroxylated metabolites of PCBs (OH-PCBs) and other chlorinated phenolic compounds in whole blood from Canadian inuit. , 2000, Environmental health perspectives.

[10]  G. Gabrielsen,et al.  Recombinant albumin and transthyretin transport proteins from two gull species and human: chlorinated and brominated contaminant binding and thyroid hormones. , 2010, Environmental science & technology.

[11]  Shin-ichi Sakai,et al.  Environmental release and behavior of brominated flame retardants. , 2003, Environment international.

[12]  S. Akiba,et al.  Determination and characterization of hydroxylated polychlorinated biphenyls (OH-PCBs) in serum and adipose tissue of Japanese women diagnosed with breast cancer. , 2010, Environmental Science and Technology.

[13]  Ronald A Hites,et al.  Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. , 2004, Environmental science & technology.

[14]  L P Hanrahan,et al.  The effects of PCB exposure and fish consumption on endogenous hormones. , 2001, Environmental health perspectives.

[15]  D. Waller,et al.  Fish ingestion and congener specific polychlorinated biphenyl and p,p'-dichlorodiphenyldichloroethylene serum concentrations in a great lakes cohort of pregnant African American women. , 2009, Environment international.

[16]  H. Hakk,et al.  Decabromodiphenyl ether in the rat: absorption, distribution, metabolism, and excretion. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[17]  R. Hites,et al.  Hydroxylated Metabolites of Polybrominated Diphenyl Ethers in Human Blood Samples from the United States , 2008, Environmental health perspectives.

[18]  Xiaowei Zhang,et al.  Origin of hydroxylated brominated diphenyl ethers: natural compounds or man-made flame retardants? , 2009, Environmental science & technology.

[19]  L. Hovander,et al.  Identification of Hydroxylated PCB Metabolites and Other Phenolic Halogenated Pollutants in Human Blood Plasma , 2002, Archives of environmental contamination and toxicology.

[20]  S. Cnattingius,et al.  Immune cell counts and risks of respiratory infections among infants exposed pre- and postnatally to organochlorine compounds: a prospective study , 2008, Environmental health : a global access science source.

[21]  V. Aleandri,et al.  PCB and other organochlorine compounds in blood of women with or without miscarriage: a hypothesis of correlation. , 1989, Ecotoxicology and environmental safety.

[22]  Christopher M Reddy,et al.  Two Abundant Bioaccumulated Halogenated Compounds Are Natural Products , 2005, Science.

[23]  Peter Höglund,et al.  Apparent Half-Lives of Hepta- to Decabrominated Diphenyl Ethers in Human Serum as Determined in Occupationally Exposed Workers , 2005, Environmental health perspectives.

[24]  R. Hites,et al.  Measurement of Polybrominated Diphenyl Ethers and Metabolites in Mouse Plasma after Exposure to a Commercial Pentabromodiphenyl Ether Mixture , 2007, Environmental health perspectives.

[25]  Joanne Jorissen Literature review. Outcomes associated with postnatal exposure to polychlorinated biphenyls (PCBs) via breast milk. , 2007, Advances in neonatal care : official journal of the National Association of Neonatal Nurses.

[26]  Myrto X Petreas,et al.  Hydroxylated PCB metabolites (OH-PCBs) in archived serum from 1950-60s California mothers: a pilot study. , 2009, Environment international.

[27]  S. Tanabe PCB problems in the future: foresight from current knowledge. , 1988, Environmental pollution.

[28]  M. van den Berg,et al.  Hydroxylation Increases the Neurotoxic Potential of BDE-47 to Affect Exocytosis and Calcium Homeostasis in PC12 Cells , 2008, Environmental health perspectives.

[29]  L. Hagmar,et al.  Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density. , 2006, Environmental science & technology.

[30]  Shinsuke Tanabe,et al.  Hydroxylated polychlorinated biphenyls (OH-PCBs) in the blood of mammals and birds from Japan: lower chlorinated OH-PCBs and profiles. , 2009, Chemosphere.

[31]  L. Kautsky,et al.  Hydroxylated and methoxylated polybrominated diphenyl ethers and polybrominated dibenzo-p-dioxins in red alga and cyanobacteria living in the Baltic Sea. , 2008, Chemosphere.

[32]  H. Inui,et al.  Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3',4,4',5-pentachlorobiphenyl. , 2011, Journal of biochemistry.

[33]  W. Miyazaki,et al.  Hydroxylated PCB induces Ca2+ oscillations and alterations of membrane potential in cultured cortical cells , 2010, Journal of applied toxicology : JAT.

[34]  S. Tanabe Environmental Specimen Bank in Ehime University (es-BANK), Japan for global monitoring. , 2006, Journal of environmental monitoring : JEM.

[35]  I. Hertz-Picciotto,et al.  Exposure to Hydroxylated Polychlorinated Biphenyls (OH-PCBs) in the Prenatal Period and Subsequent Neurodevelopment in Eastern Slovakia , 2009, Environmental health perspectives.

[36]  J. Huwe,et al.  Accumulation, whole-body depletion, and debromination of decabromodiphenyl ether in male sprague-dawley rats following dietary exposure. , 2007, Environmental science & technology.

[37]  Tomohiko Isobe,et al.  Accumulation of polychlorinated biphenyls and brominated flame retardants in breast milk from women living in Vietnamese e-waste recycling sites. , 2010, The Science of the total environment.

[38]  Tomohiko Isobe,et al.  Brominated flame retardants and polychlorinated biphenyls in human breast milk from several locations in India: potential contaminant sources in a municipal dumping site. , 2012, Environment international.

[39]  G. Marsh,et al.  Polybrominated Diphenyl Ethers (PBDEs) and Bioaccumulative Hydroxylated PBDE Metabolites in Young Humans from Managua, Nicaragua , 2007, Environmental health perspectives.

[40]  P. Grandjean,et al.  Hydroxylated PCB metabolites and PCBs in serum from pregnant Faroese women. , 2002, Environmental health perspectives.

[41]  L. Hagmar,et al.  Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men , 2000 .

[42]  Abraham Brouwer,et al.  Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[43]  H. Neels,et al.  Distribution of PCBs, their hydroxylated metabolites, and other phenolic contaminants in human serum from two European countries. , 2010, Environmental science & technology.

[44]  S. Tanabe,et al.  Organohalogen compounds and their metabolites in the blood of Japanese amberjack (Seriola quinqueradiata) and scalloped hammerhead shark (Sphyrna lewini) from Japanese coastal waters. , 2011, Chemosphere.

[45]  A. Brouwer,et al.  Binding of a 3,3', 4,4'-tetrachlorobiphenyl (CB-77) metabolite to fetal transthyretin and effects on fetal thyroid hormone levels in mice. , 1996, Toxicology.

[46]  T. Schnorr,et al.  Mortality and Exposure Response among 14,458 Electrical Capacitor Manufacturing Workers Exposed to Polychlorinated Biphenyls (PCBs) , 2006, Environmental health perspectives.

[47]  Agus Sudaryanto,et al.  Levels and congener specific profiles of PBDEs in human breast milk from China: implication on exposure sources and pathways. , 2008, Chemosphere.

[48]  R. Letcher,et al.  Metabolism of Polybrominated Diphenyl Ethers (PBDEs) by Human Hepatocytes in Vitro , 2008, Environmental health perspectives.

[49]  Shinsuke Tanabe,et al.  Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in the blood of toothed and baleen whales stranded along Japanese coastal waters. , 2010, Environmental science & technology.

[50]  Zhiqiang Yu,et al.  Identification of hydroxylated octa- and nona-bromodiphenyl ethers in human serum from electronic waste dismantling workers. , 2010, Environmental science & technology.

[51]  S. Safe,et al.  Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. , 1994, Critical reviews in toxicology.

[52]  A. Bergman,et al.  Selective retention of hydroxylated PCB metabolites in blood. , 1994, Environmental health perspectives.

[53]  I. Meerts,et al.  In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds. , 2001, Environmental health perspectives.

[54]  John E Vena,et al.  Profiles of ortho-polychlorinated biphenyl congeners, dichlorodiphenyldichloroethylene, hexachlorobenzene, and Mirex among male Lake Ontario sportfish consumers: the New York State Angler cohort study. , 2005, Environmental research.

[55]  K. Jakobsson,et al.  Occupational exposure to commercial decabromodiphenyl ether in workers manufacturing or handling flame-retarded rubber. , 2005, Environmental science & technology.

[56]  Janet Kit Yan Chan,et al.  Environmental impact and human exposure to PCBs in Guiyu, an electronic waste recycling site in China. , 2009, Environment international.

[57]  S. Freels,et al.  Congener profiles of occupational PCB exposure versus PCB exposure from fish consumption. , 2007, Chemosphere.

[58]  S. Schantz,et al.  PCB congener profile in the serum of humans consuming Great Lakes fish. , 2000, Environmental health perspectives.

[59]  M. Wolff,et al.  Changes in PCB serum concentrations among capacitor manufacturing workers. , 1992, Environmental research.

[60]  B. Bush,et al.  Fish consumption and other environmental exposures and their associations with serum PCB concentrations among Mohawk women at Akwesasne. , 2004, Environmental research.

[61]  Juliette Legler,et al.  Are brominated flame retardants endocrine disruptors? , 2003, Environment international.