Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis.

[1]  Rainer Heintzmann,et al.  Superresolution Multidimensional Imaging with Structured Illumination Microscopy , 2013 .

[2]  Jason R. Maher,et al.  Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk. , 2012, Arthritis and rheumatism.

[3]  J. Wark,et al.  Failure strength of human vertebrae: prediction using bone mineral density measured by DXA and bone volume by micro-CT. , 2012, Bone.

[4]  M. Morris,et al.  Age-specific profiles of tissue-level composition and mechanical properties in murine cortical bone. , 2012, Bone.

[5]  R. Ritchie,et al.  The Multiscale Origins of Fracture Resistance in Human Bone and Its Biological Degradation , 2012 .

[6]  R. Ritchie The conflicts between strength and toughness. , 2011, Nature materials.

[7]  Jason R. Maher,et al.  Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis. , 2011, Journal of biomedical optics.

[8]  Michael D Morris,et al.  Raman Assessment of Bone Quality , 2011, Clinical orthopaedics and related research.

[9]  J. Nyman,et al.  Raman and mechanical properties correlate at whole bone- and tissue-levels in a genetic mouse model. , 2011, Journal of biomechanics.

[10]  D. Vashishth,et al.  The relative contributions of non-enzymatic glycation and cortical porosity on the fracture toughness of aging bone. , 2011, Journal of biomechanics.

[11]  P. Dargent-Molina,et al.  Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: Sensitivity of the WHO FRAX tool , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[12]  R. Ritchie How does human bone resist fracture? , 2010, Annals of the New York Academy of Sciences.

[13]  R. Ritchie,et al.  On the Mechanistic Origins of Toughness in Bone , 2010 .

[14]  M. Saito,et al.  Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus , 2010, Osteoporosis International.

[15]  R. Recker,et al.  Use of FTIR Spectroscopic Imaging to Identify Parameters Associated With Fragility Fracture , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  Matthew J. Silva,et al.  Type 1 Diabetes in Young Rats Leads to Progressive Trabecular Bone Loss, Cessation of Cortical Bone Growth, and Diminished Whole Bone Strength and Fatigue Life , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  J. Caetano-Lopes,et al.  Biomechanical effects of inflammatory diseases on bone-rheumatoid arthritis as a paradigm. , 2009, Autoimmunity Reviews.

[18]  Fan Zhang,et al.  A novel nano-micro structured octacalcium phosphate/protein composite coating on titanium by using an electrochemically induced deposition. , 2008, Journal of biomedical materials research. Part A.

[19]  R. Ritchie,et al.  Measurement of the toughness of bone: a tutorial with special reference to small animal studies. , 2008, Bone.

[20]  D. Vashishth Small animal bone biomechanics. , 2008, Bone.

[21]  Thomas Baum,et al.  Proximal femur specimens: automated 3D trabecular bone mineral density analysis at multidetector CT--correlation with biomechanical strength measurement. , 2008, Radiology.

[22]  O. Akkus,et al.  The associations between mineral crystallinity and the mechanical properties of human cortical bone. , 2008, Bone.

[23]  C. Cooper,et al.  European guidance for the diagnosis and management of osteoporosis in postmenopausal women , 2008, Osteoporosis International.

[24]  M. O. Papuga,et al.  Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography. , 2007, Arthritis and rheumatism.

[25]  G. Mundy Osteoporosis and inflammation. , 2007, Nutrition reviews.

[26]  S. Jamal,et al.  Low bone mineral density and fracture burden in postmenopausal women , 2007, Canadian Medical Association Journal.

[27]  D. Vashishth The role of the collagen matrix in skeletal fragility , 2007, Current Osteoporosis Reports.

[28]  F. McEvoy,et al.  Relationship between bone strength and dual-energy X-ray absorptiometry measurements in pigs. , 2007, Journal of animal science.

[29]  William F. Finney,et al.  Bone tissue compositional differences in women with and without osteoporotic fracture. , 2006, Bone.

[30]  Joel W. Ager,et al.  Fracture and Ageing in Bone: Toughness and Structural Characterization , 2006 .

[31]  S. Cummings,et al.  BMD and Risk of Hip and Nonvertebral Fractures in Older Men:A Prospective Study and Comparison With Older Women , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  C. Cooper,et al.  Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. , 2006, Arthritis and rheumatism.

[33]  Nicole J. Crane,et al.  Raman spectroscopic evidence for octacalcium phosphate and other transient mineral species deposited during intramembranous mineralization. , 2006, Bone.

[34]  E. Romas Bone loss in inflammatory arthritis: mechanisms and therapeutic approaches with bisphosphonates. , 2005, Best practice & research. Clinical rheumatology.

[35]  W. Bonfield,et al.  Effect of carbonate substitution on the ultrastructural characteristics of hydroxyapatite implants , 2005, Journal of materials science. Materials in medicine.

[36]  C. Jun,et al.  Performance of some variable selection methods when multicollinearity is present , 2005 .

[37]  R O Ritchie,et al.  Deep-ultraviolet Raman spectroscopy study of the effect of aging on human cortical bone. , 2005, Journal of biomedical optics.

[38]  E. Barrett-Connor,et al.  Bone mineral density thresholds for pharmacological intervention to prevent fractures. , 2004, Archives of internal medicine.

[39]  Himadri S. Gupta,et al.  Structure and mechanical quality of the collagen–mineral nano-composite in bone , 2004 .

[40]  Fran Adar,et al.  Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone. , 2004, Bone.

[41]  C. Cooper,et al.  Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. , 2003, Arthritis and rheumatism.

[42]  S. Cummings,et al.  BMD at Multiple Sites and Risk of Fracture of Multiple Types: Long‐Term Results From the Study of Osteoporotic Fractures , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[43]  Yukio Takahashi,et al.  Evaluation of leak-before-break assessment methodology for pipes with a circumferential through-wall crack. Part I: stress intensity factor and limit load solutions , 2002 .

[44]  M. Morris,et al.  Application of vibrational spectroscopy to the study of mineralized tissues (review). , 2000, Journal of biomedical optics.

[45]  A. Hofman,et al.  Added value of bone mineral density in hip fracture risk scores. , 1999, Bone.

[46]  C. Rey,et al.  MicroRaman Spectral Study of the PO4 and CO3 Vibrational Modes in Synthetic and Biological Apatites , 1998, Calcified Tissue International.

[47]  A. Hofman,et al.  Hip Fracture Prediction in Elderly Men and Women: Validation in the Rotterdam Study , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[48]  M. Marko,et al.  Mineralization of collagen may occur on fibril surfaces: evidence from conventional and high-voltage electron microscopy and three-dimensional imaging. , 1996, Journal of structural biology.

[49]  J. Kanis,et al.  Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report , 1994, Osteoporosis International.

[50]  N. Ghannam,et al.  Book review: Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. , 1994, Annals of Saudi medicine.

[51]  J. Durig,et al.  Fourier transform raman spectroscopy of synthetic and biological calcium phosphates , 1994, Calcified Tissue International.

[52]  Milenko Markovic,et al.  Octacalcium phosphate. 3. Infrared and Raman vibrational spectra , 1993 .

[53]  S. Cummings,et al.  Bone density at various sites for prediction of hip fractures , 1993, The Lancet.

[54]  Claus Christiansen,et al.  Diagnosis of Osteoporosis , 1992, Southern medical journal.

[55]  D. Kioussis,et al.  Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. , 1991, The EMBO journal.

[56]  N. Gjerdet,et al.  Age-dependent mechanical properties of rat femur. Measured in vivo and in vitro. , 1991, Acta orthopaedica Scandinavica.

[57]  M. Glimcher Recent studies of the mineral phase in bone and its possible linkage to the organic matrix by protein-bound phosphate bonds. , 1984, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[58]  W. E. Brown,et al.  Octacalcium Phosphate and Hydroxyapatite: Crystal Structure of Octacalcium Phosphate , 1962, Nature.

[59]  P. Delmas,et al.  Mineral maturity and crystallinity index are distinct characteristics of bone mineral. , 2010 .

[60]  J. David,et al.  TNF and bone. , 2010, Current directions in autoimmunity.

[61]  O. Akkus,et al.  Local variations in the micromechanical properties of mouse femur: the involvement of collagen fiber orientation and mineralization. , 2007, Journal of biomechanics.

[62]  O. Johnell,et al.  Mortality after osteoporotic fractures , 2004, Osteoporosis International.

[63]  E. Schwarz,et al.  The TNF-alpha transgenic mouse model of inflammatory arthritis. , 2003, Springer seminars in immunopathology.

[64]  Hugo Kubinyi,et al.  3D QSAR in drug design : theory, methods and applications , 2000 .

[65]  S A Goldstein,et al.  Spatial distribution of phosphate species in mature and newly generated Mammalian bone by hyperspectral Raman imaging. , 1999, Journal of biomedical optics.

[66]  S. Wold,et al.  PLS: Partial Least Squares Projections to Latent Structures , 1993 .