Accurate quantification of steady and pulsatile flow with segmented k-space magnetic resonance velocimetry

Abstract. Conventional non-segmented magnetic resonance phase velocity mapping (MRPVM) is an accurate but relatively slow velocimetric technique. Therefore, the aim of this study was to evaluate the accuracy of the much faster segmented k-space MRPVM in quantifying flow. The axial velocity was measured in four straight tubes (inner diameter: 5.6–26.2 mm), using a segmented MRPVM sequence with seven lines of k-space per segment. The flow rate and flow volume were accurately quantified (errors<5%) under steady (r2=0.99) and pulsatile flow (r2=0.98), respectively. The measured velocity profiles and flow rates from the segmented sequence agreed with those from the non-segmented (p>0.05). Changing the slice thickness or the field of view did not affect the accuracy of the measurements. The results of this study suggest that fast, segmented MRPVM can be used for accurate flow quantification.

[1]  R. Bowtell,et al.  Magnetic resonance imaging: applications of novel methods in studies of porous media. , 1992, Magnetic resonance imaging.

[2]  P. R. Moran A flow velocity zeugmatographic interlace for NMR imaging in humans. , 1982, Magnetic resonance imaging.

[3]  A. Häkkinen,et al.  Multiphase segmented k-space velocity mapping in pulsatile flow waveforms. , 1998, Magnetic resonance imaging.

[4]  M. Bock,et al.  Interleaved gradient echo planar (IGEPI) and phase contrast CINE‐PC flow measurements in the renal artery , 1998, Journal of magnetic resonance imaging : JMRI.

[5]  C Thomsen,et al.  A segmented k‐space velocity mapping protocol for quantification of renal artery blood plow during breath‐holding , 1995, Journal of magnetic resonance imaging : JMRI.

[6]  M H Buonocore,et al.  Blood flow measurements in the aorta and major arteries with MR velocity mapping , 1994, Journal of magnetic resonance imaging : JMRI.

[7]  Lynn F. Gladden,et al.  Single- and two-phase flow in fixed-bed reactors: MRI flow visualisation and lattice-Boltzmann simulations , 2001 .

[8]  P. Callaghan,et al.  NMR VELOCIMETRY STUDY OF THE TEMPERATURE DEPENDENT RHEOLOGY OF BUTTER, SEMISOFT BUTTER AND MARGARINE , 2000 .

[9]  Motion correction for the quantification of mitral regurgitation using the control volume method , 2000, Magnetic resonance in medicine.

[10]  D N Firmin,et al.  Exercise‐related changes in aortic flow measured with spiral echo‐planar MR velocity mapping , 1995, Journal of magnetic resonance imaging : JMRI.

[11]  A P Yoganathan,et al.  Quantification of mitral regurgitation with MR phase‐velocity mapping using a control volume method , 1998, Journal of magnetic resonance imaging : JMRI.

[12]  Geoffrey A. Barrall,et al.  Use of nuclear magnetic resonance imaging as a viscometer for process monitoring , 1997 .

[13]  J. Debatin,et al.  Coronary flow and coronary flow reserve measurements in humans with breath‐held magnetic resonance phase contrast velocity mapping , 1997, Magnetic resonance in medicine.

[14]  N J Pelc,et al.  Arterial and venous blood flow: noninvasive quantitation with MR imaging. , 1992, Radiology.

[15]  P. Walker,et al.  Quantification of the aortic regurgitant volume with magnetic resonance phase velocity mapping: a clinical investigation of the importance of imaging slice location. , 1998, The Journal of heart valve disease.

[16]  P. Walker,et al.  A new control volume method for calculating valvular regurgitation. , 1995, Circulation.

[17]  Guang-Zhong Yang,et al.  Helical and Retrograde Secondary Flow Patterns in the Aortic Arch Studied by Three‐Directional Magnetic Resonance Velocity Mapping , 1993, Circulation.

[18]  J L Duerk,et al.  In-plane flow velocity quantification along the phase encoding axis in MRI. , 1988, Magnetic resonance imaging.

[19]  E. Laffon,et al.  Segmented 5 versus nonsegmented flow quantitation: comparison of portal vein flow measurements. , 1999, Investigative radiology.

[20]  D Meier,et al.  Quantitative flow measurements on phantoms and on blood vessels with MR , 1988, Magnetic resonance in medicine.

[21]  P. Walker,et al.  Slice location dependence of aortic regurgitation measurements with MR phase velocity mapping , 1997, Magnetic resonance in medicine.

[22]  K. Moser,et al.  Velocity measurements of flow through a step stenosis using Magnetic Resonance Imaging , 2000 .

[23]  C. Higgins,et al.  Severity of aortic regurgitation: interstudy reproducibility of measurements with velocity-encoded cine MR imaging. , 1992, Radiology.

[24]  Ronald J. Phillips,et al.  Magnetic resonance imaging of concentration and velocity profiles of pure fluids and solid suspensions in rotating geometries , 1995 .