Myelofibrosis Developing in Megakaryoblastic Leukemia in a Boy with Down's Syndrome

A 2 1 /2‐year‐old boy with Down's syndrome developed pancytopenia. After spontaneous recovery, leukocytosis with blast cells in peripheral blood and bone marrow developed, and it was associated with thrombocytopenia and splenomegaly. After transient but complete disappearance of all of these findings, they reappeared and a marked fluctuation with 4 subsequent peaks of leukocytosis was observed. Splenomegaly appeared in association with eukocytosis in early phase and persisted after the third peak.

[1]  N. Clare,et al.  Cytogenetic studies of peripheral myeloblasts and bone marrow fibroblasts in acute myelofibrosis. , 1982, American journal of clinical pathology.

[2]  N. Mcwilliams,et al.  Aplastic anemia and Down's syndrome. , 1982, Pediatrics.

[3]  C. Pui,et al.  Acute megakaryoblastic leukaemia associated with intrinsic platelet dysfunction and constitutional ring 21 chromosome in a young boy , 1982, British journal of haematology.

[4]  M. Oshimura,et al.  Factor(s) responsible for the increase in alkaline phosphatase activity of postmitotic granulocytes from normal individuals and patients with chronic myeloid leukemia. , 1982, Blood.

[5]  N. Kamada,et al.  Primary myelofibrosis with myeloid metaplasia and cytogenetically abnormal clones in 2 children with Down's syndrome. , 2009, Scandinavian journal of haematology.

[6]  N. Heerema,et al.  The myeloproliferative reaction in a child with down syndrome: Cytological and chromosomal evidence for a transient leukemia , 1981, American journal of hematology.

[7]  D. S. Lewis.  ASSOCIATION BETWEEN MEGAKARYOBLASTIC LEUKAEMIA AND DOWN SYNDROME , 1981, The Lancet.

[8]  B. Bain,et al.  Megakaryoblastic leukemia presenting as acute myelofibrosis -- a study of four cases with the platelet-peroxidase reaction , 1981 .

[9]  J. Ortega,et al.  Aplastic anemia in Down's syndrome. , 1981, Pediatrics.

[10]  B. Bain,et al.  Megakaryoblastic leukemia presenting as acute myelofibrosis -- a study of four cases with the platelet-peroxidase reaction. , 1981, Blood.

[11]  A. Polliack,et al.  Lymphoblastic leukemic transformation (lymphoblastic crisis) in myelofibrosis and myeloid metaplasia , 1980, American journal of hematology.

[12]  D. Weisenburger.  Acute myelofibrosis terminating as acute myeloblastic leukemia. , 1980, American journal of clinical pathology.

[13]  B. Dreyfus,et al.  Ultrastructural Localization of Peroxidases in ‘Undifferentiated’Blasts during the Blast Crisis of Chronic Granulocytic Leukaemia , 1979, British journal of haematology.

[14]  A. Manoharan,et al.  The Reticulin Content of Bone Marrow in Acute Leukaemia in Adults , 1979, British journal of haematology.

[15]  J. Humbert,et al.  Myelofibrosis and acute lymphoblastic leukemia in a child with Down syndrome. , 1979, The Journal of pediatrics.

[16]  K. Kosaka,et al.  Granulocytosis and colony‐stimulating activity (CSA) produced by a human squamous cell carcinoma , 1979, Cancer.

[17]  G. Pangalis,et al.  Acute (“malignant”) myelosclerosis , 1979, Cancer.

[18]  J. I. Spector,et al.  Acute myelofibrosis with peripheral myeloblastosis: an acute myeloproliferative disorder. , 1978, Archives of pathology & laboratory medicine.

[19]  H. B. Marsden,et al.  Bone marrow fibrosis in acute lymphoblastic leukaemia of childhood. , 1978, Journal of clinical pathology.

[20]  P. Fialkow,et al.  Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis , 1978 .

[21]  F. Reyes,et al.  Acute Leukemia : Identification by the Ultrastructural Demonstration of Platelet Peroxidase , 2022 .

[22]  P. Fialkow,et al.  Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. , 1978, Blood.

[23]  T. Bird,et al.  Malignant myelosclerosis. Myeloproliferative disorder or leukemia? , 1977, American journal of clinical pathology.

[24]  P. Raich,et al.  Acute myelofibrosis: a report of three cases. , 1977, American journal of clinical pathology.

[25]  R. Parmley,et al.  Ultrastructure and cytochemistry of bone marrow granulocytes in culture. , 1976, Experimental hematology.

[26]  D. Evans.  Acute myelofibrosis in children with Down's syndrome. , 1975, Archives of disease in childhood.

[27]  F. Rosner,et al.  Down's syndrome and acute leukemia: myeloblastic or lymphoblastic? Report of forty-three cases and review of the literature. , 1972, The American journal of medicine.

[28]  W. Crosby,et al.  Cytochemical identification of monocytes and granulocytes. , 1971, American journal of clinical pathology.

[29]  E. V. Van Slyck,et al.  Acute myelofibrosis. An accelerated variant of agnogenic myeloid metaplasia. , 1971, Annals of internal medicine.

[30]  L. Weiss,et al.  Chromosomal evidence for the secondary role of fibroblastic proliferation in acute myelofibrosis. , 1970, Blood.

[31]  G. Hug,et al.  A neonate with Down's syndrome and transient abnormal myelopoiesis: serial blood and bone marrow studies. , 1970, Blood.

[32]  M. S. Tobin,et al.  Myelofibrosis in pediatric age group. , 1969, New York state journal of medicine.

[33]  R. M. Forrester,et al.  Myelofibrosis simulating acute leukaemia in a female infant with down’s syndrome , 1968, Irish journal of medical science.

[34]  P. Krasilnikoff.  Myelofibrosis and Myeloid Leukaemia , 1967, Acta paediatrica Scandinavica.

[35]  D. R. Anderson.  Ultrastructure of normal and leukemic leukocytes in human peripheral blood. , 1966, Journal of ultrastructure research.

[36]  G. Vawter,et al.  Clinical pathological conference. The Children's Hospital Medical Center, Boston, Mass. , 1966, The Journal of pediatrics.

[37]  J. Lashof,et al.  OXFORD SURVEY OF CHILDHOOD CANCERS. PROGRESS REPORT 3. LEUKEMIA AND DOWN'S SYNDROME. , 1965, Monthly bulletin of the Ministry of Health and the Public Health Laboratory Service.

[38]  G. Bodey,et al.  RETICULIN FIBROSIS AND BONE INFARCTION IN ACUTE LEUKEMIA. IMPLICATIONS FOR PROGNOSIS. , 1964, Blood.

[39]  J. Desforges,et al.  Ineffective regulation of granulopoiesis masquerading as congenital leukemia in a mongoloid child. , 1963, The Journal of pediatrics.

[40]  G. Vawter,et al.  The Children's Hospital Medical Center, Boston, Mass. , 1963, The Journal of pediatrics.

[41]  J. Churg,et al.  OSTEOSCLEROSIS, MYELOFIBROSIS AND LEUKEMIA , 1944 .

[42]  S. Sekiya,et al.  A Simple Method for Differentiation of Myeloic and Lymphatic Leucocytes of the Human Blood , 1926 .