Estimation of In Vivo Myocardial Fibre Strain Using an Architectural Atlas of the Human Heart

We propose a methodology to estimate 3D+time maps of left ventricular (LV) fibre strain from human structural and dynamic MRI data. A biomechanical finite element model integrates fibre direction throughout the LV extracted from ex vivo human diffusion tensor MRI (DT-MRI) acquisition and motion tracked from tagged MRI (TMRI). This combination enables the estimation of fibre strain and its spatio-temporal variation throughout the cardiac cycle. The sensitivity of fibre strain estimation on the underlying fibre orientation is evaluated using a database of 7 DT-MRI and 1 TMRI datasets acquired on normal subjects. Our analysis indicates that the structure of the LV is designed for maximum homogeneity of fibre strain during ejection.

[1]  F W Prinzen,et al.  Regional fibre stress : fibre strain area as an estimate of regional blood flow and oxygen demand in the canine heart , 2005 .

[2]  Hervé Delingette,et al.  Human Atlas of the Cardiac Fiber Architecture: Study on a Healthy Population , 2012, IEEE Transactions on Medical Imaging.

[3]  E. McVeigh,et al.  Three-dimensional systolic strain patterns in the normal human left ventricle: characterization with tagged MR imaging. , 2000, Radiology.

[4]  D. H. Campen,et al.  Optimization of Cardiac Fiber Orientation for Homogeneous Fiber Strain During Ejection , 1999, Annals of Biomedical Engineering.

[5]  Patrick Clarysse,et al.  Estimation of in vivo human myocardial fibre strain by integrating diffusion tensor and tagged MRI using FE modelling , 2012, 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI).

[6]  Timothy G Reese,et al.  Imaging myocardial fiber disarray and intramural strain hypokinesis in hypertrophic cardiomyopathy with MRI , 2006, Journal of magnetic resonance imaging : JMRI.

[7]  Hervé Delingette,et al.  An electromechanical model of the heart for image analysis and simulation , 2006, IEEE Transactions on Medical Imaging.

[8]  Patrick Clarysse,et al.  Mapping Displacement and Deformation of the Heart With Local Sine-Wave Modeling , 2010, IEEE Transactions on Medical Imaging.

[9]  Pierre Croisille,et al.  Comparison of regularization methods for human cardiac diffusion tensor MRI , 2009, Medical Image Anal..

[10]  Alistair A. Young,et al.  Modelling passive diastolic mechanics with quantitative MRI of cardiac structure and function , 2009, Medical Image Anal..

[11]  Hervé Delingette,et al.  Functional Imaging and Modeling of the Heart, 5th International Conference, FIMH 2009, Nice, France, June 3-5, 2009. Proceedings , 2009, Functional Imaging and Modeling of the Heart.

[12]  Leon Axel,et al.  Dense Myocardium Deformation Estimation for 2D Tagged MRI , 2005, FIMH.