The role of nitric oxide in tumour progression

[1]  V. Kolb-Bachofen,et al.  The role of nitric oxide. , 2006, Rheumatology.

[2]  Jianjun Gao,et al.  Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model. , 2006, Cancer research.

[3]  R. Jain,et al.  Evidence for bone marrow-derived endothelial cells incorporation into perfused blood vessels in tumors , 2006 .

[4]  R. Jain,et al.  Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. , 2006, Blood.

[5]  Misa Nakamura,et al.  Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis. , 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.

[6]  L. Magnelli,et al.  Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor‐C expression in head and neck squamous cell carcinoma , 2006, The Journal of pathology.

[7]  R. Jain,et al.  Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[8]  S. Moncada,et al.  Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation. , 2006, Cancer research.

[9]  T. Fleming,et al.  Sildenafil citrate therapy for pulmonary arterial hypertension. , 2005, The New England journal of medicine.

[10]  D. Wink,et al.  Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[11]  D. Wink,et al.  Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Luigi Naldini,et al.  Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. , 2005, Cancer cell.

[13]  W. Sessa,et al.  Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[14]  R. Jain,et al.  Molecular regulation of microlymphatic formation and function: role of nitric oxide. , 2005, Trends in cardiovascular medicine.

[15]  R. Jain,et al.  NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. , 2005, The Journal of clinical investigation.

[16]  Suyun Huang,et al.  Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[17]  J. Stamler,et al.  Oxygen Regulation of Tumor Perfusion by S-Nitrosohemoglobin Reveals a Pressor Activity of Nitric Oxide , 2005, Circulation research.

[18]  Young-Myeong Kim,et al.  A molecular cascade showing nitric oxide-heme oxygenase-1-vascular endothelial growth factor-interleukin-8 sequence in human endothelial cells. , 2005, Endocrinology.

[19]  Hua Yu,et al.  Stat3 Activity in Melanoma Cells Affects Migration of Immune Effector Cells and Nitric Oxide-Mediated Antitumor Effects1 , 2005, The Journal of Immunology.

[20]  O. Feron,et al.  Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and vasodilatory effects of nitric oxide , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[21]  A. Álvarez-Barrientos,et al.  Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  E. Grimm,et al.  NO news is not necessarily good news in cancer. , 2005, Current cancer drug targets.

[23]  B. Peters,et al.  Contribution of bone marrow–derived endothelial cells to human tumor vasculature , 2005, Nature Medicine.

[24]  M. Onoda,et al.  Nitric oxide produced by inducible nitric oxide synthase is associated with mammary tumorigenesis in irradiated rats. , 2005, Nitric oxide : biology and chemistry.

[25]  R. Jain Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.

[26]  Ruth J. Muschel,et al.  Coagulation Facilitates Tumor Cell Spreading in the Pulmonary Vasculature during Early Metastatic Colony Formation , 2004, Cancer Research.

[27]  Simon C Watkins,et al.  Nitric Oxide and Ionizing Radiation Synergistically Promote Apoptosis and Growth Inhibition of Cancer by Activating p53 , 2004, Cancer Research.

[28]  Leah E. Mechanic,et al.  Nitric Oxide, a Mediator of Inflammation, Suppresses Tumorigenesis , 2004, Cancer Research.

[29]  R. Hobson,et al.  Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation. , 2004, American journal of physiology. Heart and circulatory physiology.

[30]  L. Juillerat-Jeanneret,et al.  Tumour-derived and host-derived nitric oxide differentially regulate breast carcinoma metastasis to the lungs. , 2004, Carcinogenesis.

[31]  K. Hahm,et al.  Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase , 2004, Gut.

[32]  A. Gow,et al.  Biological significance of nitric oxide-mediated protein modifications. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[33]  R. Jain,et al.  Endothelial Nitric Oxide Synthase Regulates Microlymphatic Flow via Collecting Lymphatics , 2004, Circulation research.

[34]  K. Kashfi,et al.  Nitric-oxide-donating NSAIDs as agents for cancer prevention. , 2004, Trends in molecular medicine.

[35]  W. Sessa,et al.  Caveolae and Caveolins in the Cardiovascular System , 2004, Circulation research.

[36]  C. Harris,et al.  Hypoxic inducible factor 1α, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[37]  A. Tarnawski,et al.  Dual actions of nitric oxide on angiogenesis: possible roles of PKC, ERK, and AP-1. , 2004, Biochemical and biophysical research communications.

[38]  W. Sessa eNOS at a glance , 2004, Journal of Cell Science.

[39]  V. Grégoire,et al.  Nitric oxide as a radiosensitizer: Evidence for an intrinsic role in addition to its effect on oxygen delivery and consumption , 2004, International journal of cancer.

[40]  Dai Fukumura,et al.  Tissue engineering: Creation of long-lasting blood vessels , 2004, Nature.

[41]  Rakesh K. Jain,et al.  Pathology: Cancer cells compress intratumour vessels , 2004, Nature.

[42]  B. Sipos,et al.  Tumor Stroma Interactions Induce Chemoresistance in Pancreatic Ductal Carcinoma Cells Involving Increased Secretion and Paracrine Effects of Nitric Oxide and Interleukin-1β , 2004, Cancer Research.

[43]  Y. Vodovotz,et al.  Adenoviral Gene Transfer of the Human Inducible Nitric Oxide Synthase Gene Enhances the Radiation Response of Human Colorectal Cancer Associated with Alterations in Tumor Vascularity , 2004, Cancer Research.

[44]  G. Semenza,et al.  Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling* , 2004, Journal of Biological Chemistry.

[45]  D. Heo,et al.  The effect of nitric oxide on cyclooxygenase‐2 (COX‐2) overexpression in head and neck cancer cell lines , 2003, International journal of cancer.

[46]  N. Colburn,et al.  Nitric oxide does not mediate but inhibits transformation and tumor phenotype. , 2003, Molecular cancer therapeutics.

[47]  M. Gladwin,et al.  Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation , 2003, Nature Medicine.

[48]  C. Heeschen,et al.  Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells , 2003, Nature Medicine.

[49]  Carol Cass,et al.  Nitric Oxide and Cyclic GMP Increase the Expression of Matrix Metalloproteinase-9 in Vascular Smooth Muscle , 2003, Journal of Pharmacology and Experimental Therapeutics.

[50]  P. Lala,et al.  Nitric oxide‐mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen‐activated protein kinase , 2003, International journal of cancer.

[51]  J. Maciejewski,et al.  Involvement of nitric oxide in farnesyltransferase inhibitor-mediated apoptosis in chronic myeloid leukemia cells. , 2003, Blood.

[52]  R. Arai,et al.  Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells. , 2003, Free radical biology & medicine.

[53]  R. Cardiff,et al.  Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase , 2003, International journal of cancer.

[54]  B. Brüne,et al.  Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. , 2003, Molecular biology of the cell.

[55]  Jianxin Sun,et al.  Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase Akt Pathway Mediates Nitric Oxide-Induced Endothelial Cell Migration and Angiogenesis , 2003, Molecular and Cellular Biology.

[56]  V. Steele,et al.  Is inducible nitric oxide synthase a target for chemoprevention? , 2003, Molecular cancer therapeutics.

[57]  A. Friebe,et al.  This Review Is Part of a Thematic Series on Cyclic Gmp–generating Enzymes and Cyclic Gmp–dependent Signaling, Which Includes the following Articles: Regulation of Nitric Oxide–sensitive Guanylyl Cyclase Cyclic Gmp Phosphodiesterases and Regulation of Smooth Muscle Function Structure, Regulation, and , 2022 .

[58]  Suyun Huang,et al.  Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase. , 2003, Cancer research.

[59]  R. Groszmann,et al.  Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. , 2003, Cancer cell.

[60]  D. Stewart,et al.  Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide. , 2003, The American journal of pathology.

[61]  Rakesh K Jain,et al.  Molecular regulation of vessel maturation , 2003, Nature Medicine.

[62]  Suyun Huang,et al.  Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency. , 2003, Free radical biology & medicine.

[63]  C. Harris,et al.  Nitric oxide in cancer and chemoprevention. , 2003, Free radical biology & medicine.

[64]  J. Abbruzzese,et al.  A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis , 2003, Oncogene.

[65]  N. Goren,et al.  Inducible nitric oxide synthase-mediated proliferation of a T lymphoma cell line. , 2003, Nitric oxide : biology and chemistry.

[66]  Jieli Chen,et al.  Nitric Oxide Enhances Angiogenesis via the Synthesis of Vascular Endothelial Growth Factor and cGMP After Stroke in the Rat , 2003, Circulation research.

[67]  Abu-Bakr Al-Mehdi,et al.  Arrest of B16 melanoma cells in the mouse pulmonary microcirculation induces endothelial nitric oxide synthase-dependent nitric oxide release that is cytotoxic to the tumor cells. , 2003, The American journal of pathology.

[68]  L. Dwyer-Nield,et al.  Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. , 2002, Cancer research.

[69]  Koichi Hattori,et al.  Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? , 2002, Nature Reviews Cancer.

[70]  V. Grégoire,et al.  Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[71]  C. Bucana,et al.  Lipopolysaccharide‐induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion , 2002, International journal of cancer.

[72]  L. Broemeling,et al.  A novel mechanism by which N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell growth: the production of nitric oxide. , 2002, Molecular cancer therapeutics.

[73]  C. López-Otín,et al.  Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells. , 2002, Molecular pharmacology.

[74]  Jiankun Cui,et al.  S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death , 2002, Science.

[75]  D. Warltier,et al.  Angiostatin Inhibits Coronary Angiogenesis During Impaired Production of Nitric Oxide , 2002, Circulation.

[76]  E. Chavakis,et al.  Dephosphorylation of endothelial nitric oxide synthase contributes to the anti‐angiogenic effects of endostatin , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[77]  Rakesh K Jain,et al.  Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics , 2002, Science.

[78]  C. Denkert,et al.  Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion , 2002, British Journal of Cancer.

[79]  Peter Carmeliet,et al.  Molecular mechanisms of lymphangiogenesis in health and disease. , 2002, Cancer cell.

[80]  Dai Fukumura,et al.  Dissecting tumour pathophysiology using intravital microscopy , 2002, Nature Reviews Cancer.

[81]  I. Charles,et al.  Microencapsulated iNOS‐expressing cells cause tumor suppression in mice , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[82]  I. Whittle,et al.  Glioma tumourgenicity is decreased by iNOS knockout: experimental studies using the C6 striatal implantation glioma model , 2002, British journal of neurosurgery.

[83]  X. Zhang,et al.  Metastatic melanoma cells escape from immunosurveillance through the novel mechanism of releasing nitric oxide to induce dysfunction of immunocytes , 2001, Melanoma research.

[84]  H. Ohshima,et al.  Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. , 2001, Cancer research.

[85]  B. Brüne,et al.  Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide* , 2001, The Journal of Biological Chemistry.

[86]  R. Poulsom,et al.  Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. , 2001, Gastroenterology.

[87]  Santiago Lamas,et al.  Nitrosylation The Prototypic Redox-Based Signaling Mechanism , 2001, Cell.

[88]  E C Nice,et al.  Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3 , 2001, The EMBO journal.

[89]  B Vojnovic,et al.  Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. , 2001, Cancer research.

[90]  R. Anderson,et al.  Nitric oxide synthase II gene disruption: implications for tumor growth and vascular endothelial growth factor production. , 2001, Cancer research.

[91]  P K Lala,et al.  Role of nitric oxide in carcinogenesis and tumour progression. , 2001, The Lancet. Oncology.

[92]  R K Jain,et al.  Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[93]  A. Quest,et al.  Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[94]  R. D. Rudic,et al.  In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation , 2000, Nature Medicine.

[95]  D. Nance,et al.  B16 melanoma cell arrest in the mouse liver induces nitric oxide release and sinusoidal cytotoxicity: a natural hepatic defense against metastasis. , 2000, Cancer research.

[96]  J. Fandrey,et al.  Nitric oxide affects the production of reactive oxygen species in hepatoma cells: implications for the process of oxygen sensing. , 2000, Free radical biology & medicine.

[97]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[98]  B. Roos,et al.  Gene therapy of rat medullary thyroid cancer by naked nitric oxide synthase II DNA injection , 2000, The journal of gene medicine.

[99]  S. Cederbaum,et al.  Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. , 2000, Cancer research.

[100]  Weiming Xu,et al.  Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents , 2000, Nature Cell Biology.

[101]  X. Le,et al.  Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis. , 2000, Cancer research.

[102]  T. Ohhashi,et al.  Physiological roles of endogenous nitric oxide in lymphatic pump activity of rat mesentery in vivo. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[103]  J. Gelin,et al.  Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids. , 2000, Cancer research.

[104]  C. Napoli,et al.  Nitric oxide as a signaling molecule in the vascular system: an overview. , 1999, Journal of cardiovascular pharmacology.

[105]  W. Hiddemann,et al.  Induction of inducible nitric oxide synthase is an essential part of tumor necrosis factor-alpha-induced apoptosis in MCF-7 and other epithelial tumor cells. , 1999, Laboratory investigation; a journal of technical methods and pathology.

[106]  P. Lala,et al.  Animal Model Nitric Oxide Synthase Inhibition by N G -Nitro- L Arginine Methyl Ester Inhibits Tumor-Induced Angiogenesis in Mammary Tumors , 1999 .

[107]  Yukitaka Shizukuda,et al.  Vascular Endothelial Growth Factor–Induced Endothelial Cell Migration and Proliferation Depend on a Nitric Oxide–Mediated Decrease in Protein Kinase Cδ Activity , 1999 .

[108]  T. Billiar,et al.  Nitric‐oxide production by murine mammary adenocarcinoma cells promotes tumor‐cell invasiveness , 1999, International journal of cancer.

[109]  Steven P Jones,et al.  Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. , 1999, American journal of physiology. Heart and circulatory physiology.

[110]  L. Arnould,et al.  Expression of inducible nitric oxide synthase in tumors in relation with their regression induced by lipid A in rats , 1999, International journal of cancer.

[111]  R. Heller,et al.  Nitric oxide inhibits proliferation of human endothelial cells via a mechanism independent of cGMP. , 1999, Atherosclerosis.

[112]  H. Ananthaswamy,et al.  Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53. , 1999, Cancer research.

[113]  W. Mayhan VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway. , 1999, American journal of physiology. Cell physiology.

[114]  C. Rao,et al.  Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor. , 1999, Carcinogenesis.

[115]  T. Morisaki,et al.  Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue , 1999, Journal of surgical oncology.

[116]  M. Goldberg,et al.  Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide , 1999, The Journal of Biological Chemistry.

[117]  C. Harris,et al.  p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells , 1998, Nature Medicine.

[118]  I. Whittle,et al.  Effects of nitric oxide modulation on tumour blood flow and microvascular permeability in C6 glioma , 1998, Neuroreport.

[119]  J. Isner,et al.  Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. , 1998, The American journal of pathology.

[120]  H. Kuo,et al.  Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer. , 1998, British Journal of Cancer.

[121]  Y. Vodovotz,et al.  The role of nitric oxide chemistry in cancer treatment. , 1998, Biochemistry. Biokhimiia.

[122]  T. Gupta,et al.  Role of Nitric Oxide , 1998, Digestion.

[123]  Y. Fujii‐Kuriyama,et al.  Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[124]  G. Semenza,et al.  Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer* , 1998, The Journal of Biological Chemistry.

[125]  Keith Wilson,et al.  Interleukin‐10 gene transfer inhibits murine mammary tumors and elevates nitric oxide , 1998, International journal of cancer.

[126]  E. Masini,et al.  Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. , 1998, Journal of the National Cancer Institute.

[127]  I. Fidler,et al.  Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene. , 1998, Human gene therapy.

[128]  Dai Fukumura,et al.  Role of nitric oxide in angiogenesis and microcirculation in tumors , 1998, Cancer and Metastasis Reviews.

[129]  S. Kawahara,et al.  Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore. , 1998, Chemical & pharmaceutical bulletin.

[130]  G. Garcı́a-Cardeña,et al.  Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. , 1997, The Journal of clinical investigation.

[131]  Richard Graham Knowles,et al.  Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. , 1997, Cancer research.

[132]  H. Tajiri,et al.  Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells , 1997, Oncogene.

[133]  H. Granger,et al.  Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF. , 1997, Circulation research.

[134]  G. Tozer,et al.  Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine. , 1997, Cancer research.

[135]  B. Chait,et al.  A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction. , 1997, The Journal of biological chemistry.

[136]  R. Jain,et al.  Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions. , 1997, The American journal of pathology.

[137]  K. Black,et al.  Increased brain tumor microvessel permeability after intracarotid bradykinin infusion is mediated by nitric oxide. , 1996, Cancer research.

[138]  D. Fukumura,et al.  Role in nitric oxide in Kupffer cell–mediated hepatoma cell cytotoxicity in vitro and ex vivo , 1996, Hepatology.

[139]  D. S. Lind,et al.  Tumor cell nitric oxide inhibits cell growth in vitro, but stimulates tumorigenesis and experimental lung metastasis in vivo. , 1996, The Journal of surgical research.

[140]  Y. Lau,et al.  Nitric oxide inhibits migration of cultured endothelial cells. , 1996, Biochemical and biophysical research communications.

[141]  P. K. Lala,et al.  NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis, ameliorates interleukin 2-induced capillary leakage and reduces tumour growth in adenocarcinoma-bearing mice. , 1996, British Journal of Cancer.

[142]  I. Fidler,et al.  Activation of inducible nitric oxide synthase gene in murine macrophages requires protein phosphatases 1 and 2A activities , 1995, Journal of leukocyte biology.

[143]  R. Jain,et al.  Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain. , 1995, Cancer research.

[144]  P. Kubes Nitric Oxide Affects Microvascular Permeability in the Intact and Inflamed Vasculature , 1995, Microcirculation.

[145]  W. Durán,et al.  Platelet activating factor modulates microvascular permeability through nitric oxide synthesis. , 1995, Microvascular research.

[146]  I. Fidler,et al.  Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362. , 1995, Cancer research.

[147]  P. Libby,et al.  Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. , 1995, The Journal of clinical investigation.

[148]  P Rhodes,et al.  Roles of nitric oxide in tumor growth. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[149]  I. Fidler,et al.  Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells , 1995, The Journal of experimental medicine.

[150]  Y. Uchida,et al.  Possible role of nitric oxide in 5-hydroxytryptamine-induced increase in vascular permeability in mouse skin , 1994, Naunyn-Schmiedeberg's Archives of Pharmacology.

[151]  A. M. Lefer,et al.  Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. , 1994, Gastroenterology.

[152]  Carl Nathan,et al.  Nitric oxide synthases: Roles, tolls, and controls , 1994, Cell.

[153]  H. Maeda,et al.  Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor , 1994, Japanese journal of cancer research : Gann.

[154]  S. Snyder,et al.  Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. , 1994, Science.

[155]  James B. Mitchell,et al.  Hypoxic mammalian cell radiosensitization by nitric oxide. , 1993, Cancer research.

[156]  S. Moncada,et al.  The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat , 1993, British journal of pharmacology.

[157]  M. Maragoudakis,et al.  Nitric oxide is involved in the regulation of angiogenesis , 1993, British journal of pharmacology.

[158]  I. Hart,et al.  Inhibitors of nitric oxide synthase selectively reduce flow in tumour‐associated neovasculature , 1992, British journal of pharmacology.

[159]  Y. Nunokawa,et al.  Interferon-gamma inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation. , 1992, Biochemical and biophysical research communications.

[160]  S. Moncada,et al.  Human colorectal adenocarcinoma cells: differential nitric oxide synthesis determines their ability to aggregate platelets. , 1991, Cancer research.

[161]  P. Kubes,et al.  Nitric oxide: an endogenous modulator of leukocyte adhesion. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[162]  S. Moncada,et al.  An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[163]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[164]  C. Stewart,et al.  Antimetastatic effects associated with platelet reduction. , 1968, Proceedings of the National Academy of Sciences of the United States of America.

[165]  P. Mahadevan,et al.  An overview , 2007, Journal of Biosciences.

[166]  S. Snyder,et al.  Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2 , 2005, Science.

[167]  C. Rao,et al.  Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. , 2002, Cancer research.

[168]  M. Kuroki,et al.  Specifically targeted killing of carcinoembryonic antigen (CEA)-expressing cells by a retroviral vector displaying single-chain variable fragmented antibody to CEA and carrying the gene for inducible nitric oxide synthase. , 2001, Cancer research.

[169]  M. Makuuchi,et al.  Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. , 2000, Blood.

[170]  I. Whittle,et al.  The effects of chronic nitric oxide synthase suppression on glioma pathophysiology. , 2000, British journal of neurosurgery.

[171]  P. Mehta Potential role of platelets in the pathogenesis of tumor metastasis. , 1984, Blood.