In vitro modelling of Alzheimer's disease: Degeneration and cell death induced by viral delivery of amyloid and tau

[1]  B. Platt,et al.  Culturing conditions determine neuronal and glial excitability , 2010, Journal of Neuroscience Methods.

[2]  J. Geiger,et al.  Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. , 2010, Free radical biology & medicine.

[3]  D. Selkoe,et al.  The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. , 2010, Brain : a journal of neurology.

[4]  K. Blennow,et al.  PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. , 2010, Journal of Alzheimer's disease : JAD.

[5]  D. Simon,et al.  Two pyridine derivatives as potential Cu(II) and Zn(II) chelators in therapy for Alzheimer's disease. , 2010, Dalton transactions.

[6]  M. Oz,et al.  Methylene blue and Alzheimer's disease. , 2009, Biochemical pharmacology.

[7]  Andrew J. Murray,et al.  cGMP promotes neurite outgrowth and growth cone turning and improves axon regeneration on spinal cord tissue in combination with cAMP , 2009, Brain Research.

[8]  Long-chuan Yu,et al.  Intracellular amyloid induces impairments on electrophysiological properties of cultured human neurons , 2009, Neuroscience Letters.

[9]  H. Möller,et al.  Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. , 2009, The Journal of clinical psychiatry.

[10]  P. Dolan,et al.  Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons , 2009, The Journal of Biological Chemistry.

[11]  C. Sindic,et al.  Expression of Human Amyloid Precursor Protein in Rat Cortical Neurons Inhibits Calcium Oscillations , 2009, The Journal of Neuroscience.

[12]  B. Platt,et al.  Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels , 2009, The Journal of Neuroscience.

[13]  D. Bennett,et al.  Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. , 2008, The American journal of pathology.

[14]  K. Tomoo,et al.  Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain. , 2008, Biochemical and biophysical research communications.

[15]  K. Blennow,et al.  Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial , 2008, The Lancet Neurology.

[16]  S. Cullheim,et al.  Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro , 2008, Molecular and Cellular Neuroscience.

[17]  Andrew J. Murray,et al.  Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration , 2008, Molecular and Cellular Neuroscience.

[18]  B. Winblad,et al.  APPswe mutation increases the frequency of spontaneous Ca2+-oscillations in rat hippocampal neurons , 2008, Neuroscience Letters.

[19]  Kathleen A. Boyle,et al.  Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  Till G. A. Mack,et al.  Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation , 2008, Molecular and Cellular Neuroscience.

[21]  R. Cappai,et al.  Copper binding to the Alzheimer’s disease amyloid precursor protein , 2007, European Biophysics Journal.

[22]  Grace E. Stutzmann The Pathogenesis of Alzheimers Disease—Is It a Lifelong “Calciumopathy”? , 2007, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[23]  B. Platt,et al.  Modulation of hippocampal calcium signalling and plasticity by serine/threonine protein phosphatases , 2007, Journal of neurochemistry.

[24]  L. Breydo,et al.  Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization. , 2007, Biochemistry.

[25]  F. LaFerla,et al.  Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. , 2007, The American journal of pathology.

[26]  S. Ferreira,et al.  Structure and functions of the human amyloid precursor protein: The whole is more than the sum of its parts , 2007, Progress in Neurobiology.

[27]  Bernardo L Sabatini,et al.  Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway , 2007, The Journal of Neuroscience.

[28]  K. Davies,et al.  Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. , 2006, The Biochemical journal.

[29]  T. Iwatsubo,et al.  The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. , 2006, Biochemical and biophysical research communications.

[30]  L. Zacharia,et al.  Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain β-amyloid production , 2006, Neuroscience.

[31]  E. Mandelkow,et al.  Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid‐β Peptides , 2006, Traffic.

[32]  Y. Suh,et al.  Phosphorylation of Amyloid Precursor Protein (APP) at Thr668 Regulates the Nuclear Translocation of the APP Intracellular Domain and Induces Neurodegeneration , 2006, Molecular and Cellular Biology.

[33]  J. Vickers,et al.  No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases , 2006, Neurobiology of Disease.

[34]  M. Gallagher,et al.  A specific amyloid-β protein assembly in the brain impairs memory , 2006, Nature.

[35]  M. Goedert Tau gene mutations and their effects , 2005, Movement disorders : official journal of the Movement Disorder Society.

[36]  G. Riedel,et al.  Altered Cellular Distribution of Phospho‐Tau Proteins Coincides with Impaired Retrograde Axonal Transport in Neurons of Aged Rats , 2005, Annals of the New York Academy of Sciences.

[37]  Takeshi Iwatsubo,et al.  Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins* , 2005, Journal of Biological Chemistry.

[38]  C. Haass,et al.  Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis* , 2004, Journal of Biological Chemistry.

[39]  Dominic M. Walsh,et al.  Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease , 2004, Neuron.

[40]  F. Gonzalez-Lima,et al.  Methylene blue improves brain oxidative metabolism and memory retention in rats , 2004, Pharmacology Biochemistry and Behavior.

[41]  F. Liu,et al.  Divergent roles of GSK3 and CDK5 in APP processing. , 2003, Biochemical and biophysical research communications.

[42]  L. Tsai,et al.  APP processing is regulated by cytoplasmic phosphorylation , 2003, The Journal of cell biology.

[43]  R. Jope Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. , 2003, Trends in pharmacological sciences.

[44]  B. Strooper,et al.  In Vitro Studies of Flemish, Dutch, and Wild-Type β-Amyloid Provide Evidence for Two-Staged Neurotoxicity , 2002, Neurobiology of Disease.

[45]  G. Lynch,et al.  Uptake and pathogenic effects of amyloid beta peptide 1–42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists , 2002, Neuroscience.

[46]  J. Octave,et al.  Intracellular Amyloid-β1–42, but Not Extracellular Soluble Amyloid-β Peptides, Induces Neuronal Apoptosis* , 2002, The Journal of Biological Chemistry.

[47]  W. K. Cullen,et al.  Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.

[48]  E. Mandelkow,et al.  Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress , 2002, The Journal of cell biology.

[49]  A. LeBlanc,et al.  Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons , 2002, The Journal of cell biology.

[50]  K. Tominaga-Yoshino,et al.  Neurotoxic and neuroprotective effects of glutamate are enhanced by introduction of amyloid precursor protein cDNA , 2001, Brain Research.

[51]  D. Selkoe Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.

[52]  R. Hata,et al.  Caspase-3 activation and inflammatory responses in rat hippocampus inoculated with a recombinant adenovirus expressing the Alzheimer amyloid precursor protein. , 2000, Brain research. Molecular brain research.

[53]  P. Greengard,et al.  Neuron‐Specific Phosphorylation of Alzheimer's β‐Amyloid Precursor Protein by Cyclin‐Dependent Kinase 5 , 2000, Journal of neurochemistry.

[54]  K. Jellinger,et al.  Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death. , 1999, The American journal of pathology.

[55]  I. Lieberburg,et al.  Cellular mechanisms of beta-amyloid production and secretion. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[56]  E. Koo,et al.  Recombinant adenovirus is an appropriate vector for endocytotic protein trafficking studies in cultured neurons , 1999, Journal of Neuroscience Methods.

[57]  D K Ingram,et al.  Death of PC12 cells and hippocampal neurons induced by adenoviral‐mediated FAD human amyloid precursor protein gene expression , 1999, Journal of neuroscience research.

[58]  E. Mandelkow,et al.  Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease , 1998, The Journal of cell biology.

[59]  R. Essalmani,et al.  The Long Term Adenoviral Expression of the Human Amyloid Precursor Protein Shows Different Secretase Activities in Rat Cortical Neurons and Astrocytes* , 1998, The Journal of Biological Chemistry.

[60]  H. Okamura,et al.  Degeneration In Vivo of Rat Hippocampal Neurons by Wild-Type Alzheimer Amyloid Precursor Protein Overexpressed by Adenovirus-Mediated Gene Transfer , 1998, The Journal of Neuroscience.

[61]  A. Ogura,et al.  Glutamate responsiveness enhanced in neurones expressing amyloid precursor protein , 1997, Neuroreport.

[62]  M. Roth,et al.  Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[63]  B. Winblad,et al.  Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[64]  Lawrence C. Katz,et al.  Neuronal transfection in brain slices using particle-mediated gene transfer , 1994, Neuron.

[65]  S. Squazzo,et al.  Evidence that production and release of amyloid beta-protein involves the endocytic pathway. , 1994, The Journal of biological chemistry.

[66]  Jian-Zhi Wang,et al.  Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors. , 2010, Journal of Alzheimer's disease : JAD.

[67]  L. Buée,et al.  Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. , 2010, Journal of Alzheimer's disease : JAD.

[68]  Q. Tian,et al.  Overexpression of tau proteins antagonizes amyloid-beta-potentiated apoptosis through mitochondria-caspase-3 pathway in N2a cells. , 2010, Journal of Alzheimer's disease : JAD.

[69]  H. Basun,et al.  Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease. , 2009, Journal of Alzheimer's disease : JAD.

[70]  V. Echeverria,et al.  Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice. , 2009, Journal of Alzheimer's disease : JAD.

[71]  D. Selkoe,et al.  Natural oligomers of the amyloid-β protein specifically disrupt cognitive function , 2005, Nature Neuroscience.

[72]  L. Peris,et al.  Tau Protein Function in Axonal Formation , 2004, Neurochemical Research.

[73]  Xiongwei Zhu,et al.  Abortive apoptosis in Alzheimer's disease , 2001, Acta Neuropathologica.