Angiotensin II type‐I receptor and ACE polymorphisms and risk of myocardial infarction in men and women

Findings relating an association between an insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene and myocardial infarction (MI) have been mixed. While other loci, such as the angiotensin II type‐I receptor (AT1R), may modulate risk, few studies have adequately documented the risk in women. We aimed to study whether the findings in respect of ACE and AT1R in UK men were borne out in women.

[1]  F. Cambien,et al.  Influence of angiotensin II type 1 receptor polymorphism on aortic stiffness in never-treated hypertensive patients. , 1995, Hypertension.

[2]  J. Erikssen,et al.  A DNA polymorphism at the angiotensin II type 1 receptor (AT1R) locus and myocardial infarction , 1997, Clinical genetics.

[3]  C. Patterson,et al.  Incidence, delay and survival in the Belfast MONICA Project coronary event register. , 1990, Revue d'epidemiologie et de sante publique.

[4]  J. Stricker,et al.  ACE I/D gene polymorphism: presence of the ACE D allele increases the risk of coronary artery disease in younger individuals. , 1998, Atherosclerosis.

[5]  F. Cambien,et al.  Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease. , 1994, The Quarterly journal of medicine.

[6]  T. Sørensen,et al.  ACE gene polymorphism: ischemic heart disease and longevity in 10,150 individuals. A case-referent and retrospective cohort study based on the Copenhagen City Heart Study. , 1997, Circulation.

[7]  H. Schunkert,et al.  Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. , 1994, The New England journal of medicine.

[8]  L. Peltonen,et al.  Angiotensin‐converting enzyme genotypes in the high‐ and low‐risk area for coronary heart disease in Finland , 1995, Genetic epidemiology.

[9]  N. Samani,et al.  A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction. , 1996, Circulation.

[10]  P. Amouyel,et al.  The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction. , 1997, Journal of the American College of Cardiology.

[11]  Philippe Amouyel,et al.  Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction , 1992, Nature.

[12]  A. J. Valente,et al.  Properties of apolipoprotein B in urea and in aqueous buffers. The use of glutathione and nitrogen in its solubilization. , 1981, Biochimica et biophysica acta.

[13]  A. Kurtz,et al.  Dietary salt intake modulates angiotensin II type 1 receptor gene expression. , 1997, Hypertension.

[14]  J. Carlquist,et al.  Angiotensin-converting enzyme genotypes and risk for myocardial infarction in women. , 1998, Journal of the American College of Cardiology.

[15]  P. Froguel,et al.  Genetic associations with human longevity at the APOE and ACE loci , 1994, Nature Genetics.

[16]  T. Wienker,et al.  An angiotensin-converting enzyme gene variant is associated with acute myocardial infarction in women but not in men. , 1995, The American journal of cardiology.

[17]  P. Alaupovic,et al.  Studies on the composition and structure of plasma lipoproteins. Distribution of lipoprotein families in major density classes of normal human plasma lipoproteins. , 1972, Biochimica et biophysica acta.

[18]  A. Hata,et al.  Angiotensin converting enzyme as a genetic risk factor for coronary artery spasm. Implication in the pathogenesis of myocardial infarction. , 1995, The Journal of clinical investigation.

[19]  T. Yee,et al.  Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease , 1995, The Lancet.

[20]  T. Suehiro,et al.  Significance of angiotensin I-converting enzyme and angiotensin II type 1 receptor gene polymorphisms as risk factors for coronary heart disease. , 1996, Atherosclerosis.

[21]  P Ducimetière,et al.  Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction , 1994, The Lancet.

[22]  A. Angius,et al.  [Does a genetic predisposition for infarction expansion exist? Evaluation of genetic polymorphisms of the renin-angiotensin system]. , 1997, Cardiologia.

[23]  Shirley A. Miller,et al.  A simple salting out procedure for extracting DNA from human nucleated cells. , 1988, Nucleic acids research.

[24]  P. Ducimetiere,et al.  Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study , 1996, Human Genetics.

[25]  J. Laragh,et al.  Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension. , 1991, The New England journal of medicine.

[26]  Sarah Parish,et al.  Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls , 1999, The Lancet.

[27]  R. Zulli,et al.  Angiotensin II type 1 receptor A/C1166 polymorphism. Relationships with blood pressure and cardiovascular structure. , 1996, Hypertension.