A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation
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H. Z. Wang | Moawiah M. Naffaa | Xianjin Xu | X. Zou | Yongfeng Liu | Jingyi Shi | J. Cui | I. Cohen | K. White | Alex Dou | Amy H. Cui | Panpan Hou | Junyuan Gao | Hongwu Liang | N. Yang | Wenshan Zhao | Wenjuan Kong | Guohui Zhang | Nien-Du Yang | K. M. White
[1] R. MacKinnon,et al. Structural Basis of Human KCNQ1 Modulation and Gating , 2019, Cell.
[2] Mark A. Zaydman,et al. Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation , 2019, Nature Communications.
[3] Jingyi Shi,et al. ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling , 2019, eLife.
[4] S. Heinemann,et al. Large-conductance Ca2+- and voltage-gated K+ channels form and break interactions with membrane lipids during each gating cycle , 2019, Proceedings of the National Academy of Sciences.
[5] Rui Duan,et al. Predicting protein–ligand binding modes for CELPP and GC3: workflows and insight , 2019, Journal of Computer-Aided Molecular Design.
[6] M. Shapiro,et al. Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates KCNQ3 K+ channels by interacting with four cytoplasmic channel domains , 2018, The Journal of Biological Chemistry.
[7] H. Larsson,et al. Mechanisms Underlying the Dual Effect of Polyunsaturated Fatty Acid Analogs on Kv7.1. , 2018, Cell reports.
[8] D. Fedida,et al. Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening , 2017, Nature Communications.
[9] Meng Cui,et al. Ca2+-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels , 2017, Channels.
[10] H. Kurata,et al. PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels , 2017, Proceedings of the National Academy of Sciences.
[11] R. MacKinnon,et al. Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome , 2017, Cell.
[12] L. Salkoff,et al. Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels , 2017, The Journal of general physiology.
[13] S. Heinemann,et al. Atomic determinants of BK channel activation by polyunsaturated fatty acids , 2016, Proceedings of the National Academy of Sciences.
[14] Chengfei Yan,et al. Iterative Knowledge-Based Scoring Functions Derived from Rigid and Flexible Decoy Structures: Evaluation with the 2013 and 2014 CSAR Benchmarks , 2016, J. Chem. Inf. Model..
[15] Jianmin Cui,et al. PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6 , 2015, Scientific Reports.
[16] Mark A. Zaydman,et al. Domain–domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel , 2014, eLife.
[17] K. Sampson,et al. KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps , 2014, Nature Communications.
[18] Hualiang Jiang,et al. Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating , 2013, Proceedings of the National Academy of Sciences.
[19] Mark A. Zaydman,et al. Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening , 2013, Proceedings of the National Academy of Sciences.
[20] A. Ranz,et al. Current Protocols in Protein Science , 2013 .
[21] Alison M. Thomas,et al. A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P2 , 2013, Pflügers Archiv - European Journal of Physiology.
[22] B. Chanda,et al. Thermodynamics of electromechanical coupling in voltage-gated ion channels , 2012, The Journal of general physiology.
[23] A. Gibb,et al. Distinct subunit contributions to the activation of M-type potassium channels by PI(4,5)P2 , 2012, The Journal of general physiology.
[24] S. Scherer,et al. Kv7.5 is the primary Kv7 subunit expressed in C‐fibers , 2012, The Journal of comparative neurology.
[25] E. Kaufman,et al. Mutations in Cytoplasmic Loops of the KCNQ1 Channel and the Risk of Life-Threatening Events: Implications for Mutation-Specific Response to &bgr;-Blocker Therapy in Type 1 Long-QT Syndrome , 2012, Circulation.
[26] Alison M. Thomas,et al. Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding , 2012, The Journal of Biological Chemistry.
[27] Mark A. Zaydman,et al. KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity , 2011, Proceedings of the National Academy of Sciences.
[28] Weiran Liu,et al. Lipid-dependent gating of a voltage-gated potassium channel , 2011, Nature communications.
[29] V. Vardanyan,et al. Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis. , 2011, Biophysical journal.
[30] Jeremiah D. Osteen,et al. KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate , 2010, Proceedings of the National Academy of Sciences.
[31] J. Cui,et al. KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function. , 2010, Biophysical journal.
[32] Alison M. Thomas,et al. Characterization of a Binding Site for Anionic Phospholipids on KCNQ1* , 2010, The Journal of Biological Chemistry.
[33] B. Hille,et al. Modulation of High-Voltage Activated Ca2+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate , 2010, Neuron.
[34] Juan Camilo Gómez-Posada,et al. A Pore Residue of the KCNQ3 Potassium M-Channel Subunit Controls Surface Expression , 2010, The Journal of Neuroscience.
[35] Mark A. Zaydman,et al. State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation , 2010, The Journal of general physiology.
[36] Coeli M B Lopes,et al. PKA and PKC partially rescue Long QT type 1 phenotype by restoring channel-PIP2 interactions , 2010, Channels.
[37] Michael Christiansen,et al. The genetic basis of long QT and short QT syndromes: A mutation update , 2009, Human mutation.
[38] Mark S. Shapiro,et al. Affinity for phosphatidylinositol 4,5-bisphosphate determines muscarinic agonist sensitivity of Kv7 K+ channels , 2009, The Journal of general physiology.
[39] Mark S. Johnson,et al. ShaEP: Molecular Overlay Based on Shape and Electrostatic Potential , 2009, J. Chem. Inf. Model..
[40] Zhe Lu,et al. Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels , 2008, Nature.
[41] E. Campbell,et al. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment , 2007, Nature.
[42] B. Hille,et al. Regulation of KCNQ channels by manipulation of phosphoinositides , 2007, The Journal of physiology.
[43] Xiaoqin Zou,et al. Efficient molecular docking of NMR structures: Application to HIV‐1 protease , 2006, Protein science : a publication of the Protein Society.
[44] R. MacKinnon,et al. Phospholipids and the origin of cationic gating charges in voltage sensors , 2006, Nature.
[45] Tobias Meyer,et al. Rapid Chemically Induced Changes of PtdIns(4,5)P2 Gate KCNQ Ion Channels , 2006, Science.
[46] SHENG-YOU HUANG,et al. An iterative knowledge‐based scoring function to predict protein–ligand interactions: I. Derivation of interaction potentials , 2006, J. Comput. Chem..
[47] Xiaoqin Zou,et al. An iterative knowledge‐based scoring function to predict protein–ligand interactions: II. Validation of the scoring function , 2006, J. Comput. Chem..
[48] S. Siegelbaum,et al. Regulation of Gating and Rundown of HCN Hyperpolarization-activated Channels by Exogenous and Endogenous PIP2 , 2006, The Journal of general physiology.
[49] K. Nakajo,et al. Protein kinase C shifts the voltage dependence of KCNQ/M channels expressed in Xenopus oocytes , 2005, The Journal of physiology.
[50] P. Delmas,et al. Pathways modulating neural KCNQ/M (Kv7) potassium channels , 2005, Nature Reviews Neuroscience.
[51] Yang Li,et al. Regulation of Kv7 (KCNQ) K+ Channel Open Probability by Phosphatidylinositol 4,5-Bisphosphate , 2005, The Journal of Neuroscience.
[52] J. Nerbonne,et al. Molecular physiology of cardiac repolarization. , 2005, Physiological reviews.
[53] László Virág,et al. Restricting Excessive Cardiac Action Potential and QT Prolongation: A Vital Role for IKs in Human Ventricular Muscle , 2005, Circulation.
[54] E. Campbell,et al. Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling , 2005, Science.
[55] Yasushi Okamura,et al. Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor , 2005, Nature.
[56] Conrad C. Huang,et al. UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..
[57] D. Escande,et al. Phosphatidylinositol‐4,5‐bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage‐gated potassium channels: a functional homology between voltage‐gated and inward rectifier K+ channels , 2003, The EMBO journal.
[58] Diomedes E Logothetis,et al. PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents , 2003, Neuron.
[59] Wei Huang,et al. KCNQ1 Gain-of-Function Mutation in Familial Atrial Fibrillation , 2003, Science.
[60] K. Mackie,et al. Antibodies and a cysteine‐modifying reagent show correspondence of M current in neurons to KCNQ2 and KCNQ3 K+ channels , 2002, British journal of pharmacology.
[61] Zhe Lu,et al. Coupling between Voltage Sensors and Activation Gate in Voltage-gated K+ Channels , 2002, The Journal of general physiology.
[62] B. Hille,et al. Recovery from Muscarinic Modulation of M Current Channels Requires Phosphatidylinositol 4,5-Bisphosphate Synthesis , 2002, Neuron.
[63] T. McDonald,et al. HERG K+ Channel Activity Is Regulated by Changes in Phosphatidyl Inositol 4,5-Bisphosphate , 2001, Circulation research.
[64] A. Wei,et al. Molecular Cloning and Functional Expression of KCNQ5, a Potassium Channel Subunit That May Contribute to Neuronal M-current Diversity* , 2000, The Journal of Biological Chemistry.
[65] J P Roche,et al. Reconstitution of Muscarinic Modulation of the KCNQ2/KCNQ3 K+ Channels That Underlie the Neuronal M Current , 2000, The Journal of Neuroscience.
[66] D. A. Brown,et al. Inhibition of KCNQ1‐4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors , 2000, The Journal of physiology.
[67] Thomas Friedrich,et al. KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness , 1999, Cell.
[68] B S Brown,et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. , 1998, Science.
[69] D. Hilgemann,et al. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ , 1998, Nature.
[70] P. Coumel,et al. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome , 1997, Nature Genetics.
[71] M. Sanguinetti,et al. Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel , 1996, Nature.
[72] Jacques Barhanin,et al. KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current , 1996, Nature.
[73] G. Landes,et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias , 1996, Nature Genetics.
[74] R. Mathias,et al. Isoprenaline, Ca2+ and the Na(+)‐K+ pump in guinea‐pig ventricular myocytes. , 1992, The Journal of physiology.
[75] D. A. Brown,et al. Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone , 1980, Nature.
[76] Richard Rose,et al. Citizen participation in the presidential process , 1978 .