The UNC-Wisconsin Rhesus Macaque Neurodevelopment Database: A Structural MRI and DTI Database of Early Postnatal Development

Rhesus macaques are commonly used as a translational animal model in neuroimaging and neurodevelopmental research. In this report, we present longitudinal data from both structural and diffusion MRI images generated on a cohort of 34 typically developing monkeys from 2 weeks to 36 months of age. All images have been manually skull stripped and are being made freely available via an online repository for use by the research community.

[1]  Rebecca C. Knickmeyer,et al.  Regional Gray Matter Growth, Sexual Dimorphism, and Cerebral Asymmetry in the Neonatal Brain , 2007, The Journal of Neuroscience.

[2]  G. Baird,et al.  Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP) , 2006, The Lancet.

[3]  Alexander Leemans,et al.  Microstructural maturation of the human brain from childhood to adulthood , 2008, NeuroImage.

[4]  H. Harlow,et al.  From thought to therapy: lessons from a primate laboratory. , 1971, American scientist.

[5]  M. Keshavan,et al.  Sex differences in brain maturation during childhood and adolescence. , 2001, Cerebral cortex.

[6]  J. Kulkarni,et al.  Hormone Modulation: A Novel Therapeutic Approach for Women with Severe Mental Illness , 2008, The Australian and New Zealand journal of psychiatry.

[7]  D. Mathalon,et al.  A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. , 1994, Archives of neurology.

[8]  Martin Styner,et al.  DTIPrep: quality control of diffusion-weighted images , 2014, Front. Neuroinform..

[9]  A. Riecher-Rössler,et al.  The ABC schizophrenia study: a preliminary overview of the results , 1998, Social Psychiatry and Psychiatric Epidemiology.

[10]  Rebecca C. Knickmeyer,et al.  A Structural MRI Study of Human Brain Development from Birth to 2 Years , 2008, The Journal of Neuroscience.

[11]  Karl J. Friston,et al.  Cerebral Asymmetry and the Effects of Sex and Handedness on Brain Structure: A Voxel-Based Morphometric Analysis of 465 Normal Adult Human Brains , 2001, NeuroImage.

[12]  Paul M. Thompson,et al.  Sexual dimorphism of brain developmental trajectories during childhood and adolescence , 2007, NeuroImage.

[13]  Rebecca C. Knickmeyer,et al.  Maturational trajectories of cortical brain development through the pubertal transition: unique species and sex differences in the monkey revealed through structural magnetic resonance imaging. , 2010, Cerebral cortex.

[14]  J. K. Smith,et al.  Early Postnatal Development of Corpus Callosum and Corticospinal White Matter Assessed with Quantitative Tractography , 2007, American Journal of Neuroradiology.

[15]  Yi Wang,et al.  Quality control of diffusion weighted images , 2010, Medical Imaging.

[16]  Suzanne E. Welcome,et al.  Longitudinal Mapping of Cortical Thickness and Brain Growth in Normal Children , 2022 .

[17]  P. Goldman-Rakic,et al.  Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex. , 1986, Science.

[18]  N. Andreasen,et al.  Sex differences in brain morphology in schizophrenia. , 1997, The American journal of psychiatry.

[19]  D. Kennedy,et al.  The young adult human brain: an MRI-based morphometric analysis. , 1994, Cerebral cortex.

[20]  Anders M. Dale,et al.  Frontal connections and cognitive changes in normal aging rhesus monkeys: A DTI study , 2007, Neurobiology of Aging.

[21]  Jocelyne Bachevalier,et al.  Non-human primate models of childhood psychopathology: the promise and the limitations. , 2003, Journal of child psychology and psychiatry, and allied disciplines.

[22]  Koenraad Van Leemput,et al.  Automated model-based bias field correction of MR images of the brain , 1999, IEEE Transactions on Medical Imaging.

[23]  C. Coe,et al.  Preconception maternal iron status is a risk factor for iron deficiency in infant rhesus monkeys (Macaca mulatta). , 2006, The Journal of nutrition.

[24]  Hanna Damasio,et al.  Sexual dimorphism and asymmetries in the gray–white composition of the human cerebrum , 2003, NeuroImage.

[25]  M. Ferreri,et al.  [Pervasive developmental disorders]. , 2014, La Revue du praticien.

[26]  K. Grant,et al.  Advances in nonhuman primate alcohol abuse and alcoholism research. , 2003, Pharmacology & therapeutics.

[27]  Martin Styner,et al.  Automatic regional analysis of DTI properties in the developmental macaque brain , 2008, SPIE Medical Imaging.

[28]  Ned H. Kalin,et al.  Gender differences in brain volume and size of corpus callosum and amygdala of rhesus monkey measured from MRI images , 2000, Brain Research.

[29]  Evan Fletcher,et al.  Longitudinal analysis of the developing rhesus monkey brain using magnetic resonance imaging: birth to adulthood , 2015, Brain Structure and Function.

[30]  C. Coe,et al.  Identifying immune traits and biobehavioral correlates: Generalizability and reliability of immune responses in rhesus macaques , 2006, Brain, Behavior, and Immunity.

[31]  Koenraad Van Leemput,et al.  Automated model-based tissue classification of MR images of the brain , 1999, IEEE Transactions on Medical Imaging.

[32]  J. Giedd,et al.  Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging , 2006, Neuroscience & Biobehavioral Reviews.

[33]  Alan C. Evans,et al.  Brain development during childhood and adolescence: a longitudinal MRI study , 1999, Nature Neuroscience.

[34]  A. Aguzzi,et al.  Analysis of the Prion Protein in Primates Reveals a New Polymorphism in Codon 226 (Y226F) , 2002, Biological chemistry.

[35]  C. Coe,et al.  Maternal constraint on fetal growth patterns in the rhesus monkey (Macaca mulatta): the intergenerational link between mothers and daughters. , 2000, Human reproduction.

[36]  P. Rakić,et al.  Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[37]  James G. Herndon,et al.  Nonhuman Primate Models of Cognitive Aging , 2009 .

[38]  A. Caspi,et al.  Childhood predictors differentiate life-course persistent and adolescence-limited antisocial pathways among males and females , 2001, Development and Psychopathology.

[39]  A. Reiss,et al.  Brain development, gender and IQ in children. A volumetric imaging study. , 1996, Brain : a journal of neurology.

[40]  B. Turetsky,et al.  Schizophrenia throughout life: sex differences in severity and profile of symptoms , 1996, Schizophrenia Research.

[41]  Bill Bynum,et al.  Lancet , 2015, The Lancet.

[42]  B. J. Casey,et al.  Quantitative magnetic resonance imaging of human brain development: ages 4-18. , 1996, Cerebral cortex.

[43]  J. Townsend,et al.  Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. , 2000, Radiology.

[44]  P. Rakić Development and modifiability of the cerebral cortex. , 1982, Neurosciences Research Program bulletin.

[45]  E. Fombonne,et al.  Pervasive developmental disorders in preschool children. , 2001, JAMA.

[46]  Richard Barnett Diabetes , 1904, The Lancet.

[47]  David P. Friedman,et al.  Neuroimaging of rodent and primate models of alcoholism: initial reports from the integrative neuroscience initiative on alcoholism. , 2005, Alcoholism, clinical and experimental research.

[48]  P. Szatmari,et al.  Ontario Child Health Study: prevalence of attention deficit disorder with hyperactivity. , 1989, Journal of child psychology and psychiatry, and allied disciplines.

[49]  P. Filipek,et al.  Neuroimaging in the developmental disorders: the state of the science. , 1999, Journal of child psychology and psychiatry, and allied disciplines.

[50]  Jean Bennett,et al.  Nonhuman primate models for diabetic ocular neovascularization using AAV2-mediated overexpression of vascular endothelial growth factor. , 2005, Diabetes.

[51]  Julia A. Scott,et al.  Postnatal development of the hippocampus in the Rhesus macaque (Macaca mulatta): A longitudinal magnetic resonance imaging study , 2014, Hippocampus.

[52]  Allyson J Bennett,et al.  Gene environment interplay: nonhuman primate models in the study of resilience and vulnerability. , 2008, Developmental psychobiology.

[53]  David Pinson,et al.  Nonhuman primate models of NeuroAIDS , 2008, Journal of NeuroVirology.

[54]  G. Bradley Schaefer,et al.  Quantitative Morphometric Analysis of Brain Growth Using Magnetic Resonance Imaging , 1990, Journal of child neurology.

[55]  Brian B. Avants,et al.  N4ITK: Improved N3 Bias Correction , 2010, IEEE Transactions on Medical Imaging.

[56]  Martin Styner,et al.  Diffusion imaging quality control via entropy of principal direction distribution , 2013, NeuroImage.

[57]  F. Engert,et al.  Dendritic spine changes associated with hippocampal long-term synaptic plasticity , 1999, Nature.

[58]  A. Dekaban,et al.  Changes in brain weights during the span of human life: Relation of brain weights to body heights and body weights , 1978, Annals of neurology.

[59]  D. Chklovskii,et al.  Geometry and Structural Plasticity of Synaptic Connectivity , 2002, Neuron.

[60]  Jagath C. Rajapakse,et al.  Sexual dimorphism of the developing human brain , 1997, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[61]  T. Moffitt Juvenile delinquency and attention deficit disorder: boys' developmental trajectories from age 3 to age 15. , 1990, Child development.

[62]  Jocelyne Bachevalier,et al.  Maturation of the hippocampal formation and amygdala in Macaca mulatta: A volumetric magnetic resonance imaging study , 2010, Hippocampus.

[63]  T. Jernigan,et al.  LATE CHILDHOOD CHANGES IN BRAIN MORPHOLOGY OBSERVABLE WITH MRI , 1990, Developmental medicine and child neurology.

[64]  D. Kennedy,et al.  The human brain age 7-11 years: a volumetric analysis based on magnetic resonance images. , 1996, Cerebral cortex.

[65]  B. Turetsky,et al.  Sex Differences in Brain Gray and White Matter in Healthy Young Adults: Correlations with Cognitive Performance , 1999, The Journal of Neuroscience.

[66]  Martin Styner,et al.  UNC-Utah NA-MIC framework for DTI fiber tract analysis , 2014, Front. Neuroinform..

[67]  D. Goldman,et al.  REVIEW: Non‐human primate models of inheritance vulnerability to alcohol use disorders , 2006, Addiction biology.

[68]  B. Dudek,et al.  Sex differences in brain/body relationships of Rhesus monkeys and humans. , 1999, Journal of human evolution.

[69]  N. Makris,et al.  Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. , 2001, Cerebral cortex.

[70]  Andrew L. Alexander,et al.  A Diffusion-Tensor-Based White Matter Atlas for Rhesus Macaques , 2014, PloS one.