Chagas disease and liver transplantation: Experience in Argentina using real‐time quantitative PCR for early detection and treatment

Chagas disease (CD) is an endemic zoonosis that occurs in Latin America and is caused by the parasite Trypanosoma cruzi. Early detection of T. cruzi in liver transplant recipients at risk may avoid complications from CD. The aim of this study was to examine the pre‐operative evaluation and follow‐up of CD after liver transplantation (LT) of patients at risk of CD using real‐time quantitative polymerase chain reaction (qPCR) for T. cruzi.

[1]  J. Caeiro,et al.  Reactivation of Chagas Disease in a Patient With Follicular Lymphoma Diagnosed by Means of Quantitative Real-Time Polymerase Chain Reaction , 2015, Open forum infectious diseases.

[2]  R. Lattes,et al.  Chagas disease in the immunosuppressed patient. , 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[3]  M. Blanes,et al.  Early Molecular Diagnosis of Acute Chagas Disease After Transplantation With Organs From Trypanosoma cruzi–Infected Donors , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[4]  R. Striker,et al.  Donor‐Derived Trypanosoma cruzi Infection in Solid Organ Recipients in the United States, 2001–2011 , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[5]  L. McCormack,et al.  Liver Transplantation Using Chagas‐Infected Donors in Uninfected Recipients: A Single‐Center Experience Without Prophylactic Therapy , 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[6]  Research priorities for Chagas disease, human African trypanosomiasis and leishmaniasis. , 2012, World Health Organization technical report series.

[7]  S. Sauleda,et al.  Safety of liver transplantation with chagas disease–seropositive donors for seronegative recipients , 2011, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[8]  V. L. D. de Freitas,et al.  Real-Time PCR in HIV/Trypanosoma cruzi Coinfection with and without Chagas Disease Reactivation: Association with HIV Viral Load and CD4+ Level , 2011, PLoS neglected tropical diseases.

[9]  M. Ison,et al.  Organ Donor Screening Practices for Trypanosoma cruzi Infection among US Organ Procurement Organizations , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[10]  M. Ison,et al.  Screening and Treatment of Chagas Disease in Organ Transplant Recipients in the United States: Recommendations from the Chagas in Transplant Working Group , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[11]  A. Assal,et al.  International Study to Evaluate PCR Methods for Detection of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients , 2011, PLoS neglected tropical diseases.

[12]  D. Casadei.  Chagas' disease and solid organ transplantation. , 2010, Transplantation proceedings.

[13]  J. Tuttle-Newhall,et al.  Disparities in liver transplantation before and after introduction of the MELD score. , 2008, JAMA.

[14]  S. Sauleda,et al.  Development of a real-time PCR assay for Trypanosoma cruzi detection in blood samples. , 2007, Acta tropica.

[15]  L. D'Albuquerque,et al.  Liver Transplantation from Deceased Donors Serologically Positive for Chagas Disease , 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[16]  S. Inatomi,et al.  The safety of , 2006 .

[17]  L. Barcan,et al.  Transmission of T. cruzi infection via liver transplantation to a nonreactive recipient for Chagas' disease , 2005, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[18]  O. Salomone,et al.  Using polymerase chain reaction in early diagnosis of re-activated Trypanosoma cruzi infection after heart transplantation. , 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[19]  R. Favaloro,et al.  Early diagnosis of recurrence of Trypanosoma cruzi infection by polymerase chain reaction after heart transplantation of a chronic Chagas' heart disease patient. , 2000, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[20]  E. Segura,et al.  Chagas' disease in patients with kidney transplants: 7 years of experience 1989-1996. , 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[21]  A. House,et al.  Banff schema for grading liver allograft rejection: utility in clinical practice. , 1999, Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.