Breaking old paradigms: Th17 cells in autoimmune arthritis.

[1]  L. Wedderburn,et al.  Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis. , 2009, Rheumatology.

[2]  F. D’Acquisto,et al.  Interleukin 17 sustains rather than induces inflammation. , 2009, Biochemical pharmacology.

[3]  M. Rossol,et al.  Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation. , 2009, Blood.

[4]  E. Podack,et al.  APRIL (TNFSF13) regulates collagen‐induced arthritis, IL‐17 production and Th2 response , 2008, European journal of immunology.

[5]  W. Nacken,et al.  Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis. , 2008, Arthritis and rheumatism.

[6]  M. Hashizume,et al.  IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. , 2008, Rheumatology.

[7]  S. Alzabin,et al.  Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells , 2008, The Journal of experimental medicine.

[8]  J. Goldberg,et al.  IL-17 Is a Critical Component of Vaccine-Induced Protection against Lung Infection by Lipopolysaccharide-Heterologous Strains of Pseudomonas aeruginosa1 , 2008, The Journal of Immunology.

[9]  B. Zheng,et al.  Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis , 2008, Proceedings of the National Academy of Sciences.

[10]  B. Lim,et al.  Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression1 , 2008, The Journal of Immunology.

[11]  T. Glant,et al.  Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. , 2008, Arthritis and rheumatism.

[12]  L. Steinman.  A rush to judgment on Th17 , 2008, The Journal of experimental medicine.

[13]  D. Ganea,et al.  In Vitro Differentiation of Dendritic Cells in the Presence of Prostaglandin E2 Alters the IL-12/IL-23 Balance and Promotes Differentiation of Th17 Cells1 , 2008, The Journal of Immunology.

[14]  Y. Iwakura,et al.  Development of Proteoglycan-Induced Arthritis Is Independent of IL-171 , 2008, The Journal of Immunology.

[15]  S. Zheng,et al.  Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-61 , 2008, The Journal of Immunology.

[16]  P. Baeuerle,et al.  Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor α-independent mouse model , 2008, Annals of the rheumatic diseases.

[17]  Tiina Laitala-Leinonen,et al.  Osteoclast lineage and function. , 2008, Archives of biochemistry and biophysics.

[18]  Jianping Jin,et al.  Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes , 2008, The Journal of Immunology.

[19]  H. Takayanagi,et al.  The dynamic interplay between osteoclasts and the immune system. , 2008, Archives of biochemistry and biophysics.

[20]  Sung-Hwan Park,et al.  IL-17 induces the production of IL-16 in rheumatoid arthritis , 2008, Experimental & Molecular Medicine.

[21]  J. Lord,et al.  Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha , 2008, Arthritis research & therapy.

[22]  S-Y Hwang,et al.  Oral administration of type-II collagen suppresses IL-17-associated RANKL expression of CD4+ T cells in collagen-induced arthritis. , 2008, Immunology letters.

[23]  Amita Aggarwal,et al.  Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. , 2008, The Journal of rheumatology.

[24]  K. Paraskevas.  Statin treatment for rheumatoid arthritis: a promising novel indication , 2008, Clinical Rheumatology.

[25]  T. Miyazaki,et al.  High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis. , 2008, The Journal of rheumatology.

[26]  Yuka Kanno,et al.  Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. , 2008, Blood.

[27]  Chen Dong,et al.  T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. , 2008, Immunity.

[28]  Y. Iwamoto,et al.  Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis , 2007, Annals of the rheumatic diseases.

[29]  T. Mcclanahan,et al.  TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology , 2007, Nature Immunology.

[30]  Hiromu Ito,et al.  Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model , 2007, The Journal of experimental medicine.

[31]  N. Tsuno,et al.  IL-17B and IL-17C Are Associated with TNF-α Production and Contribute to the Exacerbation of Inflammatory Arthritis1 , 2007, The Journal of Immunology.

[32]  M. Gajda,et al.  Exacerbation of Antigen-Induced Arthritis in IFN-γ-Deficient Mice As a Result of Unrestricted IL-17 Response1 , 2007, The Journal of Immunology.

[33]  Kenji Chiba.  IL-15, IL-17を標的とした新しい経口抗リウマチ薬の研究開発 , 2007 .

[34]  N. Kamatani,et al.  IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats , 2007, Arthritis research & therapy.

[35]  P. Lazzerini,et al.  Simvastatin inhibits cytokine production and nuclear factor-kB activation in interleukin 1beta-stimulated synoviocytes from rheumatoid arthritis patients. , 2007, Clinical and experimental rheumatology.

[36]  D. Ganea,et al.  Prostaglandin E2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis. , 2007, Arthritis and rheumatism.

[37]  M. van Lookeren Campagne,et al.  A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis , 2007, The Journal of experimental medicine.

[38]  Graham M Lord,et al.  The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease , 2007, Clinical and experimental immunology.

[39]  K. Elkon,et al.  Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17. , 2007, Arthritis and rheumatism.

[40]  Masaaki Takahashi,et al.  Treatment with anti-TNF-α antibody infliximab reduces serum IL-15 levels in patients with rheumatoid arthritis , 2007, Clinical Rheumatology.

[41]  Satoshi Tanaka,et al.  T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis , 2007, The Journal of experimental medicine.

[42]  Y. Kadono,et al.  Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction , 2006, The Journal of experimental medicine.

[43]  J. Thurman,et al.  Alternative Complement Pathway Activation Is Essential for Inflammation and Joint Destruction in the Passive Transfer Model of Collagen-Induced Arthritis1 , 2006, The Journal of Immunology.

[44]  Y. Okada,et al.  Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis. , 2006, Biochemical and biophysical research communications.

[45]  Q. Zhong,et al.  IL-17 Receptor Knockout Mice Have Enhanced Myelotoxicity and Impaired Hemopoietic Recovery Following Gamma Irradiation , 2006, The Journal of Immunology.

[46]  R. D. Hatton,et al.  Transforming growth factor-β induces development of the TH17 lineage , 2006, Nature.

[47]  A. Facchini,et al.  Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts. , 2006, Osteoarthritis and cartilage.

[48]  A. Amcheslavsky,et al.  Interleukin (IL)‐12 mediates the anti‐osteoclastogenic activity of CpG‐oligodeoxynucleotides , 2006, Journal of cellular physiology.

[49]  T. Miyazaki,et al.  Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. , 2006, The Journal of rheumatology.

[50]  K. Yudoh,et al.  Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. , 2006, Arthritis and rheumatism.

[51]  J. H. Lee,et al.  IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes , 2006, Clinical Rheumatology.

[52]  N. Kamatani,et al.  IFN‐γ‐producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL , 2005, European journal of immunology.

[53]  L. Joosten,et al.  Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. , 2005, Arthritis and rheumatism.

[54]  J. Pers,et al.  BAFF Overexpression Is Associated with Autoantibody Production in Autoimmune Diseases , 2005, Annals of the New York Academy of Sciences.

[55]  B. Troen,et al.  RANK ligand and interferon gamma differentially regulate cathepsin gene expression in pre-osteoclastic cells. , 2005, Biochemical and biophysical research communications.

[56]  F. Ruschitzka,et al.  Simvastatin improves endothelial function in patients with rheumatoid arthritis. , 2005, Journal of the American College of Cardiology.

[57]  C. Brinckerhoff,et al.  Selective retinoic acid receptor ligands for rheumatoid arthritis. , 2004, Current opinion in investigational drugs.

[58]  L. Stamp,et al.  Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: role of interleukin 17 and tumor necrosis factor-alpha. , 2004, The Journal of rheumatology.

[59]  M. Lotze,et al.  Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts. , 2004, Immunology letters.

[60]  W. Li,et al.  Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes. , 2004, Cellular signalling.

[61]  Ju-Young Kim,et al.  IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways , 2004, Arthritis research & therapy.

[62]  T. Mcclanahan,et al.  Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation , 2003, The Journal of experimental medicine.

[63]  S. Nakae,et al.  Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice 1 , 2003, The Journal of Immunology.

[64]  Z. Song,et al.  IFNγ deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vβ6 and Vβ8 in arthritic joints , 2003 .

[65]  J. Lapointe,et al.  Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[66]  S. Goldring,et al.  Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. , 2003, Rheumatology.

[67]  L. Joosten,et al.  IL-17 Promotes Bone Erosion in Murine Collagen-Induced Arthritis Through Loss of the Receptor Activator of NF-κB Ligand/Osteoprotegerin Balance 1 , 2003, The Journal of Immunology.

[68]  J. Pelletier,et al.  Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis. , 2002, The Journal of rheumatology.

[69]  E. Schwarz,et al.  Exposure to receptor-activator of NFκB ligand renders pre-osteoclasts resistant to IFN-γ by inducing terminal differentiation , 2002, Arthritis research & therapy.

[70]  M. Cutolo,et al.  Synovial fluid from patients with rheumatoid arthritis inhibits neutrophil apoptosis: role of adenosine and proinflammatory cytokines. , 2002, Rheumatology.

[71]  E. Filvaroff,et al.  Interleukin 17 induced nitric oxide suppresses matrix synthesis and protects cartilage from matrix breakdown. , 2002, The Journal of rheumatology.

[72]  A. Rowan,et al.  Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines , 2002, Annals of the rheumatic diseases.

[73]  A. Kehlen,et al.  Expression, modulation and signalling of IL‐17 receptor in fibroblast‐like synoviocytes of patients with rheumatoid arthritis , 2002, Clinical and experimental immunology.

[74]  T. Martin,et al.  Involvement of receptor activator of NFκB ligand and tumor necrosis factor-α in bone destruction in rheumatoid arthritis , 2002 .

[75]  M. Korabiowska,et al.  Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease , 2001, Gut.

[76]  K. Hillan,et al.  Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo. , 2001, Cytokine.

[77]  W. B. van den Berg,et al.  Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain. , 2001, Arthritis and rheumatism.

[78]  J. Bijlsma,et al.  Interleukin 10 (IL-10), not IL-4 or interferon-gamma production, correlates with progression of joint destruction in rheumatoid arthritis. , 2001, The Journal of rheumatology.

[79]  L. Joosten,et al.  IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis1 , 2001, The Journal of Immunology.

[80]  M. Leach,et al.  Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death , 2001, The Journal of Immunology.

[81]  Y. Sugimoto,et al.  Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists. , 2001, Biochemical pharmacology.

[82]  N. Kamatani,et al.  Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. , 2001, Arthritis and rheumatism.

[83]  C. Löwik,et al.  Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: is there dependency on nuclear factor-kappaB and receptor activator of nuclear factor kappaB (RANK)/RANK ligand signaling? , 2001, Bone.

[84]  L. Joosten,et al.  IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis , 2001, Arthritis research.

[85]  S. Hsieh,et al.  Enhanced Secretion of IFN-γ by Activated Th1 Cells Occurs Via Reverse Signaling Through TNF-Related Activation-Induced Cytokine1 , 2001, The Journal of Immunology.

[86]  A. Hoffmann,et al.  Regulation of IL-6 and IL-8 Expression in Rheumatoid Arthritis Synovial Fibroblasts: the Dominant Role for NF-κB But Not C/EBPβ or c-Jun1 , 2000, The Journal of Immunology.

[87]  L. Ballou,et al.  The genetic ablation of cyclooxygenase 2 prevents the development of autoimmune arthritis. , 2000, Arthritis and rheumatism.

[88]  J. Dayer,et al.  Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. , 2000, Cytokine.

[89]  L. Joosten,et al.  IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. , 2000, The Journal of clinical investigation.

[90]  L. Joosten,et al.  Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4. , 2000, Arthritis and rheumatism.

[91]  J. Pelletier,et al.  Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis. , 2000, Arthritis and rheumatism.

[92]  O. Nadiv,et al.  IL‐17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts , 2000, Clinical and experimental immunology.

[93]  W. Maśliński,et al.  High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism1 , 2000, The Journal of Immunology.

[94]  H. Nagafuchi,et al.  Characterization of Tissue Outgrowth Developed in vitro in Patients with Rheumatoid Arthritis: Involvement of T Cells in the Development of Tissue Outgrowth , 2000, International Archives of Allergy and Immunology.

[95]  S. Fiorito,et al.  Intracytoplasmic Th1 and Th2 cytokines in rheumatoid arthritis blood and synovial tissue. , 1999, Journal of autoimmunity.

[96]  F. Breedveld,et al.  Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis. , 1999, Journal of immunology.

[97]  H. Makino,et al.  Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. , 1999, Arthritis and rheumatism.

[98]  T. Martin,et al.  IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. , 1999, The Journal of clinical investigation.

[99]  P. Miossec,et al.  Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. , 1999, Arthritis and rheumatism.

[100]  J. Quach,et al.  Interleukin-17-induced Gene Expression in Articular Chondrocytes Is Associated with Activation of Mitogen-activated Protein Kinases and NF-κB* , 1998, The Journal of Biological Chemistry.

[101]  P. Miossec,et al.  Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. , 1998, Journal of immunology.

[102]  N. Udagawa,et al.  Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone. , 1998, Biochemical and biophysical research communications.

[103]  D. Lacey,et al.  Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation , 1998, Cell.

[104]  D. Bishop,et al.  Alloantigen-reactive Th1 development in IL-12-deficient mice. , 1998, Journal of immunology.

[105]  W. B. van den Berg,et al.  Effect of interleukin 1 and leukaemia inhibitory factor on chondrocyte metabolism in articular cartilage from normal and interleukin-6-deficient mice: role of nitric oxide and IL-6 in the suppression of proteoglycan synthesis. , 1997, Cytokine.

[106]  A. Billiau,et al.  Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. , 1997, Journal of immunology.

[107]  F. Breedveld,et al.  Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. , 1997, Arthritis and rheumatism.

[108]  H. Nishiura,et al.  IL-8/NAP-1 is the major T-cell chemoattractant in synovial tissues of rheumatoid arthritis. , 1996, Clinical immunology and immunopathology.

[109]  N. Udagawa,et al.  Interleukin‐6 and soluble interleukin‐6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast‐like cell formation , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[110]  F. Finkelman,et al.  Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2 , 1994, The Journal of experimental medicine.

[111]  L. Punzi,et al.  Interrelationships between interleukin (IL)-1, IL-6 and IL-8 in synovial fluid of various arthropathies , 1994, Agents and Actions.

[112]  H. Mcdevitt,et al.  Heterogeneous effects of IFN-gamma in adjuvant arthritis. , 1989, Journal of immunology.

[113]  O. Mellbye,et al.  Complement activation in rheumatoid arthritis evaluated by C3dg and the terminal complement complex. , 1986, Arthritis and rheumatism.

[114]  Vlad I. Morariu,et al.  Expression , 2015, Principles of Molecular Virology.

[115]  K. Chiba.  [A new orally active anti-rheumatic drug targets IL-15 and IL-17]. , 2007, Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.

[116]  S-Y Hwang,et al.  Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappaB- and p38 MAPK-dependent signalling pathways. , 2007, Rheumatology.

[117]  C. Brinckerhoff,et al.  Matrix metalloproteinases: role in arthritis. , 2006, Frontiers in bioscience : a journal and virtual library.

[118]  J. Peschon,et al.  Requirement of local synovial IL-17 receptor signaling in the progression of chronic synovitis and bone erosion in arthritis , 2004 .

[119]  P. Wooley,et al.  IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints. , 2003, Annals of the rheumatic diseases.

[120]  T. Martin,et al.  Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. , 2002, Bone.

[121]  M. Feldmann,et al.  Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? , 2001, Annual review of immunology.

[122]  T. Taniguchi,et al.  T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. , 2000, Nature.

[123]  T. Martin,et al.  Tumor Necrosis Factor (cid:97) Stimulates Osteoclast Differentiation by a Mechanism Independent of the ODF/RANKL–RANK Interaction , 2022 .