论文信息 - A 16 × 16 multi-electrode array with integrated CMOS amplifiers for neural signal recording

A 16 × 16 multi-electrode array with integrated CMOS amplifiers for neural signal recording

This paper reports on an active 16 × 16, low-noise, low-power, multi-electrode array (MEA) neural sensor chip designed in IBM BiCMOS 8HP 0.13µm process with a total gain of 60 dB per input, a 20 kHz sample rate, an input-referred noise of 5.3 µVrms over 10 Hz to 10 kHz and a total power dissipation of 15.8 mW, or 61.7 µW per channel. A C4 microelectrode is attached to the input of each amplifier forming a multi-electrode array with 200 µm pitch for extracellular neural recording.

Lu Wang | Mesut Sahin | Ronald W. Knepper | David S. Freedman | M. Selim Unlu

[1] R. R. Harrison,et al. A low-power low-noise CMOS amplifier for neural recording applications , 2003, IEEE J. Solid State Circuits.

[2] Andreas Hierlemann,et al. Switch-Matrix-Based High-Density Microelectrode Array in CMOS Technology , 2010, IEEE Journal of Solid-State Circuits.

[3] Yannick Bornat,et al. Large-Scale, High-Resolution Data Acquisition System for Extracellular Recording of Electrophysiological Activity , 2008, IEEE Transactions on Biomedical Engineering.

[4] B. Eversmann,et al. A 128 × 128 CMOS bio-sensor array for extracellular recording of neural activity , 2003 .

[5] Ying Yao,et al. An Implantable 64-Channel Wireless Microsystem for Single-Unit Neural Recording , 2009, IEEE Journal of Solid-State Circuits.

[6] D. Schmitt-Landsiedel,et al. A 128 /spl times/ 128 CMOS bio-sensor array for extracellular recording of neural activity , 2003, 2003 IEEE International Solid-State Circuits Conference, 2003. Digest of Technical Papers. ISSCC..

[7] R. Genov,et al. 256-Channel Neural Recording and Delta Compression Microsystem With 3D Electrodes , 2009, IEEE Journal of Solid-State Circuits.