Knee arthropathy: when things go wrong

Summary.  Joint bleeding, or haemarthrosis, is the most common type of bleeding episode experienced by individuals with haemophilia A and B. This leads to changes within the joints, including synovial proliferation, which results in further bleeding and chronic synovitis. Blood in the joint can also directly damage the cartilage, and with repeated bleeding, there is progressive destruction of both cartilage and bone. The end result is known as haemophilic arthropathy which is characterized by pain, stiffness and deformity. The joint most commonly affected is the knee. Haemophilic arthropathy can be prevented through regular prophylaxis and physiotherapy. However, when necessary, there are multiple surgical and non‐surgical options available. These procedures are indicated to improve the joint function and quality of life for haemophilic patients worldwide. In this review, the role of surgical and non‐surgical treatment of advanced knee arthropathy and its complications will be described.

[1]  M. Page,et al.  Preoperative education for hip or knee replacement. , 2014, The Cochrane database of systematic reviews.

[2]  N. Goddard,et al.  Perioperative clotting factor replacement and infection in total knee arthroplasty , 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

[3]  J. Parvizi,et al.  Periprosthetic joint infection: treatment options. , 2010, Orthopedics.

[4]  J. Luck,et al.  Management of arthrofibrosis in haemophilic arthropathy , 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

[5]  F. Querol,et al.  Influence of aquatic training on the motor performance of patients with haemophilic arthropathy , 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

[6]  Michael A. Mont,et al.  Static progressive stretch improves range of motion in arthrofibrosis following total knee arthroplasty , 2010, Knee Surgery, Sports Traumatology, Arthroscopy.

[7]  Simone Cerciello,et al.  Stiffness in total knee arthroplasty , 2009, Journal of Orthopaedics and Traumatology.

[8]  P. Mannucci,et al.  Factors influencing the long‐term outcome of primary total knee replacement in haemophiliacs: a review of 116 procedures at a single institution , 2009, British journal of haematology.

[9]  C. Hermans,et al.  The role of physiotherapy after total knee arthroplasty in patients with haemophilia , 2008, Haemophilia : the official journal of the World Federation of Hemophilia.

[10]  A. I. d'Young.  Domiciliary application of CryoCuff in severe haemophilia: qualitative questionnaire and clinical audit , 2008, Haemophilia.

[11]  P. Heidari,et al.  Trapezoid supracondylar femoral extension osteotomy for knee flexion contractures in patients with haemophilia , 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

[12]  J. Luck,et al.  Flexion Contractures of the Knee in Haemophilia , 2007 .

[13]  T. Seyler,et al.  Functional problems and arthrofibrosis following total knee arthroplasty. , 2007, The Journal of bone and joint surgery. American volume.

[14]  D. Fisher,et al.  Looks good but feels bad: factors that contribute to poor results after total knee arthroplasty. , 2007, The Journal of arthroplasty.

[15]  Alan R. Cohen,et al.  Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. , 2007, The New England journal of medicine.

[16]  H. Langberg,et al.  Myofibre damage in human skeletal muscle: effects of electrical stimulation versus voluntary contraction , 2007, The Journal of physiology.

[17]  L. Padua,et al.  Range of Motion Correlates with Patient Perception of TKA Outcome , 2007, Clinical orthopaedics and related research.

[18]  J. Bijlsma,et al.  Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: an in vitro study. , 2007, Arthritis and rheumatism.

[19]  G. Scuderi**.  The stiff total knee arthroplasty: causality and solution. , 2005, The Journal of arthroplasty.

[20]  Chris M Gregory,et al.  Recruitment patterns in human skeletal muscle during electrical stimulation. , 2005, Physical therapy.

[21]  L. Valentino,et al.  Pathobiology of hemophilic synovitis I: overexpression of mdm2 oncogene. , 2004, Blood.

[22]  F. Buechel.  The infected total knee arthroplasty: just when you thought it was over. , 2004, The Journal of arthroplasty.

[23]  L. Valentino,et al.  Experimental haemophilic synovitis: rationale and development of a murine model of human factor VIII deficiency , 2004, Haemophilia : the official journal of the World Federation of Hemophilia.

[24]  S Hetrick,et al.  Pre-operative education for hip or knee replacement. , 2004, The Cochrane database of systematic reviews.

[25]  E G Tuddenham,et al.  The hemophilias--from royal genes to gene therapy. , 2001, The New England journal of medicine.

[26]  L. Heijnen,et al.  Physiotherapy for the treatment of articular contractures in haemophilia , 1999, Haemophilia : the official journal of the World Federation of Hemophilia.

[27]  H. Caviglia,et al.  Extensor supracondylar femoral osteotomy as treatment for flexed haemophilic knee , 1999, Haemophilia : the official journal of the World Federation of Hemophilia.

[28]  J. Bijlsma,et al.  Iron deposits and catabolic properties of synovial tissue from patients with haemophilia. , 1998, The Journal of bone and joint surgery. British volume.

[29]  B. M. Buzzard,et al.  Physiotherapy for prevention and treatment of chronic hemophilic synovitis. , 1997, Clinical orthopaedics and related research.

[30]  M. Heim,et al.  The fixed flexed and subluxed knee in the haemophilic child: what should be done? , 1996, Haemophilia : the official journal of the World Federation of Hemophilia.

[31]  I. Novàkovà,et al.  Total knee replacement in haemophilic arthropathy. , 1988, The Journal of bone and joint surgery. British volume.

[32]  M. Painter,et al.  Patterns of bleeding in adolescents with severe haemophilia A. , 1979, British medical journal.

[33]  L. Sokoloff.  BIOCHEMICAL AND PHYSIOLOGICAL ASPECTS OF DEGENERATIVE JOINT DISEASES WITH SPECIAL REFERENCE TO HEMOPHILIC ARTHROPATHY * , 1975, Annals of the New York Academy of Sciences.