A global overview of pleiotropy and genetic architecture in complex traits

[1]  Doug Speed,et al.  SumHer better estimates the SNP heritability of complex traits from summary statistics , 2018, Nature Genetics.

[2]  Anthony J. Payne,et al.  Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps , 2018, Nature Genetics.

[3]  P. Donnelly,et al.  The UK Biobank resource with deep phenotyping and genomic data , 2018, Nature.

[4]  O. Andreassen,et al.  Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model , 2017, bioRxiv.

[5]  P. Visscher,et al.  Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model , 2018, Cell.

[6]  P. Visscher,et al.  Meta-analysis of genome-wide association studies for height and body mass index in ∼700,000 individuals of European ancestry , 2018, bioRxiv.

[7]  D. Balding,et al.  Better estimation of SNP heritability from summary statistics provides a new understanding of the genetic architecture of complex traits , 2018, bioRxiv.

[8]  S. Djurovic,et al.  Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation , 2017, bioRxiv.

[9]  C. Greenwood,et al.  Genetic architecture: the shape of the genetic contribution to human traits and disease , 2017, Nature Reviews Genetics.

[10]  D. Posthuma,et al.  Functional mapping and annotation of genetic associations with FUMA , 2017, Nature Communications.

[11]  Nicola J. Rinaldi,et al.  Genetic effects on gene expression across human tissues , 2017, Nature.

[12]  M. Pirinen,et al.  Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies. , 2017, American journal of human genetics.

[13]  K. Rawlik,et al.  An atlas of genetic associations in UK Biobank , 2017, Nature Genetics.

[14]  P. Visscher,et al.  10 Years of GWAS Discovery: Biology, Function, and Translation. , 2017, American journal of human genetics.

[15]  O. Andreassen,et al.  Estimating phenotypic polygenicity and causal effect size variance from GWAS summary statistics while accounting for inflation due to cryptic relatedness , 2017 .

[16]  Yang I Li,et al.  An Expanded View of Complex Traits: From Polygenic to Omnigenic , 2017, Cell.

[17]  Doug Speed,et al.  Re-evaluation of SNP heritability in complex human traits , 2016, Nature Genetics.

[18]  Tom R. Gaunt,et al.  LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis , 2016, bioRxiv.

[19]  P. Visscher,et al.  Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets , 2016, Nature Genetics.

[20]  James Y. Zou Analysis of protein-coding genetic variation in 60,706 humans , 2015, Nature.

[21]  M. Schober,et al.  Challenges and Strategies , 2016 .

[22]  P. Farnham,et al.  Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome , 2015, Epigenetics & Chromatin.

[23]  Christian Gieger,et al.  Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci , 2016 .

[24]  Gabor T. Marth,et al.  A global reference for human genetic variation , 2015, Nature.

[25]  Matti Pirinen,et al.  FINEMAP: efficient variable selection using summary data from genome-wide association studies , 2015, bioRxiv.

[26]  Mark I. McCarthy,et al.  Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci , 2015, PLoS genetics.

[27]  P. Visscher,et al.  Nature Genetics Advance Online Publication , 2022 .

[28]  Joris M. Mooij,et al.  MAGMA: Generalized Gene-Set Analysis of GWAS Data , 2015, PLoS Comput. Biol..

[29]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[30]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[31]  Joris M. Mooij,et al.  MAGMA: Generalized Gene-Set Analysis of GWAS Data , 2015, PLoS Comput. Biol..

[32]  G. Abecasis,et al.  Rare-variant association analysis: study designs and statistical tests. , 2014, American journal of human genetics.

[33]  Naomi R. Wray,et al.  Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples , 2014, PLoS genetics.

[34]  Jun S. Liu,et al.  Genetics of rheumatoid arthritis contributes to biology and drug discovery , 2013 .

[35]  Peggy Hall,et al.  The NHGRI GWAS Catalog, a curated resource of SNP-trait associations , 2013, Nucleic Acids Res..

[36]  C. Wallace,et al.  Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics , 2013, PLoS genetics.

[37]  S. Purcell,et al.  Pleiotropy in complex traits: challenges and strategies , 2013, Nature Reviews Genetics.

[38]  P. Henderson,et al.  The Role of Autophagy in Crohn’s Disease , 2012, Cells.

[39]  Helga Thorvaldsdóttir,et al.  Molecular signatures database (MSigDB) 3.0 , 2011, Bioinform..

[40]  E. Lander Initial impact of the sequencing of the human genome , 2011, Nature.

[41]  H. Hakonarson,et al.  ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.

[42]  Judy H. Cho,et al.  Finding the missing heritability of complex diseases , 2009, Nature.

[43]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[44]  A. Barabasi,et al.  The human disease network , 2007, Proceedings of the National Academy of Sciences.

[45]  A. Edwards,et al.  Complement Factor H Polymorphism and Age-Related Macular Degeneration , 2005, Science.

[46]  J. Ott,et al.  Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.

[47]  M. DePamphilis,et al.  HUMAN DISEASE , 1957, The Ulster Medical Journal.