Centri-voltammetric detection of epinephrine

The present study demonstrates a novel approach that has been proposed for epinephrine detection by using centri-voltammetry. The principle of the method is based on the accumulation of an analyte, here epinephrine, onto an electrode surface via centrifugal force. After the accumulation of epinephrine, a direct voltammetric scan was performed in a specially fabricated centri-voltammetric cell. A remarkable increase in the oxidation peak current of epinephrine was observed in the case of centrifuge application. Experimental parameters like the centrifugation speed and centrifugation time were optimized and then the analytical characteristics were examined. Two linear ranges were obtained between 0.2–20 μM and 50–500 μM for epinephrine and limit of detection (LOD) values were also calculated for both linear ranges to be 0.013 μM and 0.043 μM, respectively. As a practical application, the developed method was applied to epinephrine detection in adrenaline ampoule samples.

[1]  Marina Falkova,et al.  Flow method based on cloud point extraction for fluorometric determination of epinephrine in human urine. , 2016, Analytica chimica acta.

[2]  G. Sulka,et al.  Nanoporous spongelike Au–Ag films for electrochemical epinephrine sensing , 2016 .

[3]  M. Saraji,et al.  Selective micro solid-phase extraction of epinephrine, norepinephrine and dopamine from human urine and plasma using aminophenylboronic acid covalently immobilized on magnetic nanoparticles followed by high-performance liquid chromatography-fluorescence detection , 2016 .

[4]  G. Neri,et al.  Simultaneous electrochemical determination of epinephrine and uric acid in the presence of ascorbic acid using SnO2/graphene nanocomposite modified glassy carbon electrode , 2015 .

[5]  H. Beitollahi,et al.  Fabrication of a Nanostructure Based Electrochemical Sensor for Voltammetric Determination of Epinephrine, Uric Acid and Folic Acid , 2015 .

[6]  E. Sezer,et al.  Combination of a poly(3,4-ethylene-dioxythiophene) electrode in the presence of sodium dodecyl sulfate with centri-voltammetry , 2015 .

[7]  T. Khezeli,et al.  Dispersive micro-solid-phase extraction of dopamine, epinephrine and norepinephrine from biological samples based on green deep eutectic solvents and Fe3O4@MIL-100 (Fe) core–shell nanoparticles grafted with pyrocatechol , 2015 .

[8]  Ülkü Anık,et al.  Bismuth Nanoparticles Incorporated Centri‐voltammetry for Phenol Detection , 2015 .

[9]  Ronald J. Mascarenhas,et al.  Electropolymerization of bromothymol blue on carbon paste electrode bulk modified with oxidized multiwall carbon nanotubes and its application in amperometric sensing of epinephrine in pharmaceutical and biological samples , 2014 .

[10]  B. Rezaei,et al.  NiFe2O4 nanoparticles decorated with MWCNTs as a selective and sensitive electrochemical sensor for the determination of epinephrine using differential pulse voltammetry , 2014 .

[11]  E. Sezer,et al.  Centri-voltammetric dopamine detection , 2014 .

[12]  Ronald J. Mascarenhas,et al.  Pristine multi-walled carbon nanotubes/SDS modified carbon paste electrode as an amperometric sensor for epinephrine. , 2014, Talanta.

[13]  Z. Zhang,et al.  A novel chemiluminescence system with diperiodatonickelate (IV) for the determination of adrenaline. , 2014, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[14]  R. Madhuri,et al.  Multiwalled carbon nanotubes bearing 'terminal monomeric unit' for the fabrication of epinephrine imprinted polymer-based electrochemical sensor. , 2013, Biosensors & bioelectronics.

[15]  Ülkü Anık.  Centri-voltammetry and biocentri-voltammetry: a review , 2013, Microchimica Acta.

[16]  S. Koçak,et al.  Centri-voltammetric determination of molybdenum , 2013 .

[17]  S. Timur,et al.  Biocentri-voltammetric biosensor for acetylcholine and choline , 2012, Microchimica Acta.

[18]  S. Timur,et al.  Biocentri-voltammetry for the enzyme assay: a model study , 2012 .

[19]  A. Akbari,et al.  Application of a modified carbon nanotube paste electrode for simultaneous determination of epinephrine, uric acid and folic acid , 2012 .

[20]  S. Çevik,et al.  Centri-voltammetry for biosensing systems: biocentri-voltammetric xanthine detection , 2011 .

[21]  Sunita Bishnoi,et al.  A novel multi-walled carbon nanotube modified sensor for the selective determination of epinephrine in smokers , 2011 .

[22]  N. Nasirizadeh,et al.  Simultaneous determination of ascorbic acid, adrenaline and uric acid at a hematoxylin multi-wall carbon nanotube modified glassy carbon electrode , 2010 .

[23]  F. Ertaş,et al.  Centrifugation: an efficient technique for preconcentration in anodic stripping voltammetric analysis of mercury using a gold film electrode , 2009 .

[24]  S. Shahrokhian,et al.  Application of carbon-paste electrode modified with iron phthalocyanine for voltammetric determination of epinephrine in the presence of ascorbic acid and uric acid , 2009 .

[25]  F. Nil Ertaş,et al.  Centri-voltammetric study with amberlite XAD-7 resin as a carrier system. , 2004, Talanta.

[26]  Ülkü Anik Kirgöz,et al.  A New Procedure for Voltammetric Lead Determination Based on Coprecipitation and Centrifugation Preconcentration , 2004 .

[27]  G. Sulka,et al.  Fabrication of highly ordered nanoporous thin Au films and their application for electrochemical determination of epinephrine , 2016 .

[28]  M. Çubukçu,et al.  Centri-voltammetric determination of glutathione , 2012, Microchimica Acta.