miR-511-3 p Modulates Genetic Programs of Tumor-Associated Macrophages

Mario Leonardo Squadrito,1,3 Ferdinando Pucci,1,3 Laura Magri,2,3 Davide Moi,1 Gregor D. Gilfillan,4 Anna Ranghetti,1 Andrea Casazza,5 Massimiliano Mazzone,5 Robert Lyle,4 Luigi Naldini,1,3 and Michele De Palma1,6,* 1Angiogenesis and Tumor Targeting Unit, and HSR-TIGET, Division of Regenerative Medicine 2Neural Stem Cell Biology Unit, Division of Regenerative Medicine San Raffaele Institute, 20132-Milan, Italy 3Vita-Salute San Raffaele University, 20132-Milan, Italy 4Department of Medical Genetics and Norwegian High-Throughput Sequencing Centre (NSC), Oslo University Hospital, Kirkeveien 166, 0407-Oslo, Norway 5Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB and K.U. Leuven, 3000 Leuven, Belgium 6Present address: The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland *Correspondence: michele.depalma@epfl.ch DOI 10.1016/j.celrep.2011.12.005

[1]  A. Chawla,et al.  Macrophage-mediated inflammation in metabolic disease , 2011, Nature Reviews Immunology.

[2]  Ryan D. Morin,et al.  Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. , 2011, Blood.

[3]  F. Su,et al.  Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells , 2011, Molecular Cancer.

[4]  Hans Clevers,et al.  Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth. , 2024, Cancer cell.

[5]  R. Kolde,et al.  MicroRNA Expression Profiles of Human Blood Monocyte-derived Dendritic Cells and Macrophages Reveal miR-511 as Putative Positive Regulator of Toll-like Receptor 4* , 2011, The Journal of Biological Chemistry.

[6]  M. Squadrito,et al.  Macrophage regulation of tumor angiogenesis: implications for cancer therapy. , 2011, Molecular aspects of medicine.

[7]  Mikala Egeblad,et al.  Dynamic interplay between the collagen scaffold and tumor evolution. , 2010, Current opinion in cell biology.

[8]  S. Gordon,et al.  Alternative activation of macrophages: mechanism and functions. , 2010, Immunity.

[9]  L. Coussens,et al.  Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity , 2010, Cancer and Metastasis Reviews.

[10]  Jeffrey W. Pollard,et al.  Macrophage Diversity Enhances Tumor Progression and Metastasis , 2010, Cell.

[11]  Ryan M. O’Connell,et al.  Physiological and pathological roles for microRNAs in the immune system , 2010, Nature Reviews Immunology.

[12]  Nectarios Koziris,et al.  Accurate microRNA target prediction correlates with protein repression levels , 2009, BMC Bioinformatics.

[13]  A. Sica,et al.  A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships. , 2009, Blood.

[14]  Yi Jiang,et al.  Topography of Extracellular Matrix Mediates Vascular Morphogenesis and Migration Speeds in Angiogenesis , 2009, PLoS Comput. Biol..

[15]  S. Gordon,et al.  Alternative activation of macrophages: an immunologic functional perspective. , 2009, Annual review of immunology.

[16]  S. Lorkowski,et al.  Production of Type VI Collagen by Human Macrophages: A New Dimension in Macrophage Functional Heterogeneity1 2 , 2008, The Journal of Immunology.

[17]  J. Kitzman,et al.  Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. , 2007, RNA.

[18]  L. Lim,et al.  MicroRNA targeting specificity in mammals: determinants beyond seed pairing. , 2007, Molecular cell.

[19]  A. Sica,et al.  Altered macrophage differentiation and immune dysfunction in tumor development. , 2007, The Journal of clinical investigation.

[20]  R. Akhurst,et al.  TGF beta inhibition for cancer therapy. , 2006, Current cancer drug targets.

[21]  Raghu Kalluri,et al.  Fibroblasts in cancer , 2006, Nature Reviews Cancer.

[22]  Luigi Naldini,et al.  Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. , 2005, Cancer cell.

[23]  D. Bartel,et al.  Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. , 2005, RNA.

[24]  L. Naldini,et al.  Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters , 2005, Nature Biotechnology.

[25]  S. Jayasena,et al.  Functional siRNAs and miRNAs Exhibit Strand Bias , 2003, Cell.

[26]  S Gordon,et al.  Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation , 1992, The Journal of experimental medicine.

[27]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[28]  S Gordon,et al.  Macrophage receptors and immune recognition. , 2005, Annual review of immunology.

[29]  L. Naldini,et al.  Transduction of a gene expression cassette using advanced generation lentiviral vectors. , 2002, Methods in enzymology.