Development of sensor surface with recognition of molecular substructure

A biological olfaction system is one of the highest performance chemical sensing systems for low-molecular-weight compounds. An ability of recognizing a various molecular properties based on their structures is essential for a biological odor recognition process. For the development of a sensor mimicking the olfactory system, we have formed benzene-patterned self-assembled monolayer (SAM) on the sensor surface using SAMs with nanostructure that serves as adsorption sites for benzene ring, which is representative substructure of aromatics. The structure of the benzene-patterned SAM surface was analyzed by contact-angle measurement, ellipsometry, cyclic voltammetry (CV) and atomic force microscopy (AFM). Moreover, the electrodes evaluated as sensor surfaces with cyclic surface-polarization impedance (cSPI) sensor that measures changes in impedance of the electrode surface by adsorption of substances. The results of cSPI indicated the benzene-patterned SAM surface could distinguish benzene by recognizing of the hydrophobicity and the molecular size.

[1]  R. Araneda,et al.  The molecular receptive range of an odorant receptor , 2000, Nature Neuroscience.

[2]  K. Uosaki,et al.  In Situ Scanning Tunneling Microscopy Observation of the Self-Assembly Process of Alkanethiols on Gold(111) in Solution , 1998 .

[3]  G M Shepherd,et al.  Emerging principles of molecular signal processing by mitral/tufted cells in the olfactory bulb. , 1994, Seminars in cell biology.

[4]  F. Schreiber.  Structure and growth of self-assembling monolayers , 2000 .

[5]  Kenshi Hayashi,et al.  Detection of aromatic nitro compounds with electrode polarization controlling sensor , 2005 .

[6]  Frances S. Ligler,et al.  Immobilized biomolecules in analysis : a practical approach , 1998 .

[7]  Kiyoshi Toko,et al.  Functionalization of gold surfaces using benzene-patterned self-assembled monolayers for surface-polarization controlling method , 2003 .

[8]  J. Zak,et al.  Voltammetric reductive desorption characteristics of alkanethiolate monolayers at single crystal Au(111) and (110) electrode surfaces , 1997 .

[9]  Emilia Morallón,et al.  Electrochemical behaviour of benzene on platinum electrodes , 2000 .

[10]  T. Pajkossy.  Capacitance dispersion on solid electrodes: anion adsorption studies on gold single crystal electrodes , 1997 .

[11]  R. Axel,et al.  A novel multigene family may encode odorant receptors: A molecular basis for odor recognition , 1991, Cell.

[12]  Kiyoshi Toko,et al.  Discrimination of pungent-tasting substances using surface-polarity controlled sensor with indirect in situ modification , 2003 .

[13]  Sandeep Kumar,et al.  Self-assembled monolayers (SAMs) of alkoxycyanobiphenyl thiols on gold--a study of electron transfer reaction using cyclic voltammetry and electrochemical impedance spectroscopy. , 2006, Journal of colloid and interface science.

[14]  G. Scoles,et al.  Energetics and Kinetics of the Physisorption of Hydrocarbons on Au(111) , 1998 .

[15]  T. Pajkossy,et al.  On the origin of capacitance dispersion of rough electrodes , 2000 .

[16]  Takamichi Nakamoto,et al.  Classification and evaluation of sensing films for QCM odor sensors by steady-state sensor response measurement , 2000 .

[17]  U. Rammelt,et al.  On the applicability of a constant phase element (CPE) to the estimation of roughness of solid metal electrodes , 1990 .

[18]  L. Buck,et al.  Combinatorial Receptor Codes for Odors , 1999, Cell.

[19]  K. Uosaki,et al.  In Situ, Real Time Monitoring of the Self-Assembly Process of Decanethiol on Au(111) in Liquid Phase. A Scanning Tunneling Microscopy Investigation , 1997 .

[20]  Kenshi Hayashi,et al.  Odor sensor with water membrane using surface polarity controlling method and analysis of responses to partial structures of odor molecules , 2004 .

[21]  G. Whitesides,et al.  Self-assembled monolayers of thiolates on metals as a form of nanotechnology. , 2005, Chemical reviews.

[22]  K. Toko,et al.  Detection of Environmental Hormones with Electrode Polarity Controlled Method , 2001 .

[23]  K. Toko,et al.  Evaluation of the odor quality by substructures of odor molecules using integrated multi-channel odor sensor , 2005, The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05..