Radiation‐induced sarcomas following childhood cancer – A Canadian Sarcoma Research and Clinical Collaboration Study (CanSaRCC)

Radiation‐induced sarcoma (RIS) is a late toxicity of radiation therapy (RT) usually associated with poor prognosis. Due to ongoing improvements in childhood cancer treatment and patient outcomes, RIS may become more prevalent notwithstanding evolving indications for RT. Due to limited reported studies, we sought to review our experience with RIS in survivors of pediatric cancer.

[1]  H. Schmidberger,et al.  Childhood Cancer: Occurrence, Treatment and Risk of Second Primary Malignancies , 2021, Cancers.

[2]  P. Rutkowski,et al.  The Management of Radiation-Induced Sarcomas: A Cohort Analysis from a Sarcoma Tertiary Center , 2021, Journal of clinical medicine.

[3]  D. Tsang,et al.  Proton beam therapy for cancer , 2019, Canadian Medical Association Journal.

[4]  R. Madan,et al.  Radiation induced secondary malignancies: a review article , 2018, Radiation oncology journal.

[5]  M. Tattersall,et al.  Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study , 2017, British Journal of Cancer.

[6]  K. Kelly,et al.  Long-term results of CCG 5942: a randomized comparison of chemotherapy with and without radiotherapy for children with Hodgkin's lymphoma--a report from the Children's Oncology Group. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  A. Mavrogenis,et al.  Post‐radiation sarcomas. Clinical outcome of 52 Patients , 2012, Journal of surgical oncology.

[8]  Per Nilsson,et al.  Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma , 2011, Acta oncologica.

[9]  P. Hoskin,et al.  Reduced dose radiotherapy for local control in non-Hodgkin lymphoma: a randomised phase III trial. , 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[10]  Christos Kremmydas.  Childhood , 2010, The Classical Review.

[11]  G. Armstrong,et al.  Long-Term Effects of Radiation Exposure among Adult Survivors of Childhood Cancer: Results from the Childhood Cancer Survivor Study , 2010, Radiation research.

[12]  Y. Shimada,et al.  Risk of second malignant neoplasms among childhood cancer survivors treated with radiotherapy: meta-analysis of nine epidemiological studies. , 2009, Paediatric and perinatal epidemiology.

[13]  Abigail Walton,et al.  Radiation-induced second malignancies. , 2008, Journal of palliative medicine.

[14]  D. Lefkopoulos,et al.  Risk of a second malignant neoplasm after cancer in childhood treated with radiotherapy: correlation with the integral dose restricted to the irradiated fields. , 2008, International journal of radiation oncology, biology, physics.

[15]  R. Grimer,et al.  Radiation-induced sarcomas of bone: factors that affect outcome. , 2007, The Journal of bone and joint surgery. British volume.

[16]  L. Strong,et al.  Secondary sarcomas in childhood cancer survivors: a report from the Childhood Cancer Survivor Study. , 2007, Journal of the National Cancer Institute.

[17]  C. Bonaïti‐pellié,et al.  Radiation and genetic factors in the risk of second malignant neoplasms after a first cancer in childhood , 1997, The Lancet.