Studies on Sustained Release IV: Inert Matrix Tablets of Sulfamethizole, Employing Pdlyvinyl Chloride and Carboxypolymethylene

AbstractAn inert matrix type sulfamethizole sustained release dosage form is attempted, using polyvinyl chloride and carboxypolymethylene. The release obtained with the flow -through cell is lower than the target profile. With the rotating bottle apparatus, higher release rates were obtained, but based upon our previous findings, the latter method is considered not to be very realistic.Upon the kinetic assessment of dissolution data, zero order, first order and Hixson-Crowell kinetics were found to give similar fits.