Epigenetic Patterns Modulate the Connection Between Developmental Dynamics of Parenting and Offspring Psychosocial Adjustment.

This study attempted to establish and quantify the connections between parenting, offspring psychosocial adjustment, and the epigenome. The participants, 35 African American young adults (19 females and 16 males; age = 17-29.5 years), represented a subsample of a 3-wave longitudinal 15-year study on the developmental trajectories of low-income urban mother-offspring dyads. Mothers were assessed on their perceptions of maternal stress at each wave. Offspring were assessed on their perceptions of maternal parenting at each wave and on their adaptive and maladaptive behavior at the last wave. Genome-wide DNA methylation in peripheral T lymphocytes at the third wave was assayed using Methyl Binding Domain(MBD) sequencing. Statistically significant associations were identified between the change in offspring's perception of parenting from middle childhood to adulthood and the DNA methylation in offspring's adult genomes. Specifically, the slope of perceived parental rejection across the 3 time points was related to an increase in methylation, or a potential downregulation, of 565 genes thought to be involved in the control of a broad spectrum of biological functions generally related to cellular signaling. A subset of these epigenetic marks, clustered in 23 genes, some of which participate in the development and functioning of the CNS, were in turn associated with psychosocial adjustment as captured by interpersonal relationships and emotional self-evaluation. This appears to be one of the first investigations of the modulating role of the methylome in associations between developmental dynamics of parenting throughout the formative years of child and adolescent development and psychosocial adjustment in adulthood.

[1]  David Moore,et al.  Behavioral epigenetics , 2017, Wiley interdisciplinary reviews. Systems biology and medicine.

[2]  J. Mill,et al.  Genome-wide Methylomic Analysis of Monozygotic Twins Discordant for Adolescent Depression , 2014, Biological Psychiatry.

[3]  E. Grigorenko,et al.  Reciprocal influences between maternal parenting and child adjustment in a high-risk population: a 5-year cross-lagged analysis of bidirectional effects. , 2014, The American journal of orthopsychiatry.

[4]  M. Pembrey,et al.  Childhood abuse is associated with methylation of multiple loci in adult DNA , 2014, BMC Medical Genomics.

[5]  D. Siniscalco,et al.  Epigenetic Findings in Autism: New Perspectives for Therapy , 2013, International journal of environmental research and public health.

[6]  M. Szyf DNA methylation, behavior and early life adversity. , 2013, Journal of genetics and genomics = Yi chuan xue bao.

[7]  Ellen T. Gelfand,et al.  The Genotype-Tissue Expression (GTEx) project , 2013, Nature Genetics.

[8]  M. Rutter Achievements and challenges in the biology of environmental effects , 2012, Proceedings of the National Academy of Sciences.

[9]  Stephen Scott Parenting quality and children's mental health: biological mechanisms and psychological interventions , 2012, Current opinion in psychiatry.

[10]  W. McArdle,et al.  Associations with early-life socio-economic position in adult DNA methylation. , 2012, International journal of epidemiology.

[11]  E. Grigorenko,et al.  Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents , 2011, Development and Psychopathology.

[12]  F. Bloomfield Epigenetic modifications may play a role in the developmental consequences of early life events , 2011, Journal of Neurodevelopmental Disorders.

[13]  D. Skuse,et al.  Behavioral epigenetics , 2011, Annals of the New York Academy of Sciences.

[14]  Cathi B. Propper,et al.  Systems theory and cascades in developmental psychopathology , 2010, Development and Psychopathology.

[15]  D. Kohen,et al.  Associations among child care, family, and behavior outcomes in a nation-wide sample of preschool-aged children , 2010 .

[16]  Gustavo Turecki,et al.  Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse , 2009, Nature Neuroscience.

[17]  Kristopher J Preacher,et al.  Latent Growth Curve Modeling , 2008 .

[18]  Initial Reliability and Validity of the BASC-2, SRP, College Version , 2008 .

[19]  G. S. Pettit,et al.  Commentary on Special Section on “Bidirectional Parent–Child Relationships”: The Continuing Evolution of Dynamic, Transactional Models of Parenting and Youth Behavior Problems , 2008, Journal of abnormal child psychology.

[20]  D. Pardini Novel Insights into Longstanding Theories of Bidirectional Parent–Child Influences: Introduction to the Special Section , 2008, Journal of abnormal child psychology.

[21]  Patrick O. McGowan,et al.  The social environment and the epigenome , 2008, Environmental and molecular mutagenesis.

[22]  G. Boss,et al.  Signaling by small GTPases in the immune system , 2007, Immunological reviews.

[23]  R. Dahl,et al.  Resilience among children and adolescents at risk for depression: Mediation and moderation across social and neurobiological contexts , 2007, Development and Psychopathology.

[24]  M. Meaney,et al.  Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome , 2005, Dialogues in clinical neuroscience.

[25]  Michael J Meaney,et al.  Epigenetic programming by maternal behavior , 2004, Nature Neuroscience.

[26]  A. Khaleque,et al.  Perceived Parental Acceptance‐Rejection and Psychological Adjustment: A Meta‐Analysis of Cross‐Cultural and Intracultural Studies , 2002 .

[27]  G. Dawson,et al.  The role of early experience in shaping behavioral and brain development and its implications for social policy , 2000, Development and Psychopathology.

[28]  C. Di Pietro,et al.  Purine nucleotide metabolism: specific aspects in chronic lymphocytic leukemia lymphocytes. , 1997, Biochimica et biophysica acta.

[29]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .