AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling

[1]  B. A. French,et al.  Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy , 2022, Science Translational Medicine.

[2]  Chengqi Xu,et al.  Angiogenic factor AGGF1 blocks neointimal formation after vascular injury via interaction with integrin α7 on vascular smooth muscle cells , 2022, The Journal of biological chemistry.

[3]  A. Sun,et al.  Legumain Is an Endogenous Modulator of Integrin αvβ3 Triggering Vascular Degeneration, Dissection, and Rupture , 2022, Circulation.

[4]  Qiuyun Chen,et al.  Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis , 2021, Arteriosclerosis, thrombosis, and vascular biology.

[5]  A. Ma,et al.  Global Burden of Aortic Aneurysm and Attributable Risk Factors from 1990 to 2017 , 2021, Global heart.

[6]  T. Hu,et al.  Recent progress in TGF-β inhibitors for cancer therapy. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[7]  T. Quertermous,et al.  Single-Cell Transcriptomic Profiling of Vascular Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm , 2020, Arteriosclerosis, thrombosis, and vascular biology.

[8]  C. Owen,et al.  ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)–Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm , 2020, Arteriosclerosis, thrombosis, and vascular biology.

[9]  J. Golledge,et al.  Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm. , 2020, American journal of physiology. Heart and circulatory physiology.

[10]  Qiuyun Chen,et al.  ADAMTS16 Activates Latent TGF-beta, Accentuating Fibrosis and Dysfunction of the Pressure-overloaded Heart. , 2019, Cardiovascular research.

[11]  K. Eagle,et al.  Update on Clinical Trials of Losartan With and Without β-Blockers to Block Aneurysm Growth in Patients With Marfan Syndrome: A Review. , 2019, JAMA cardiology.

[12]  G. Mancini,et al.  De novo loss-of-function KCNMA1 variants are associated with a new multiple malformation syndrome and a broad spectrum of developmental and neurological phenotypes. , 2019, Human molecular genetics.

[13]  Qiuyun Chen,et al.  Angiogenic Factor AGGF1-Primed Endothelial Progenitor Cells Repair Vascular Defect in Diabetic Mice , 2019, Diabetes.

[14]  S. Nathan,et al.  Efficacy of Pirfenidone in the Context of Multiple Disease Progression Events in Patients With Idiopathic Pulmonary Fibrosis , 2019, Chest.

[15]  Chunyan Luo,et al.  UBC9 regulates cardiac sodium channel Nav1.5 ubiquitination, degradation and sodium current density. , 2019, Journal of molecular and cellular cardiology.

[16]  Gregory T. Jones,et al.  Genetics of Thoracic and Abdominal Aortic Diseases. , 2019, Circulation research.

[17]  J. Golledge.  Abdominal aortic aneurysm: update on pathogenesis and medical treatments , 2018, Nature Reviews Cardiology.

[18]  S. McClure,et al.  Epidemiology and management of thoracic aortic dissections and thoracic aortic aneurysms in Ontario, Canada: A population‐based study , 2018, The Journal of thoracic and cardiovascular surgery.

[19]  D. Sheppard,et al.  TGF-β1 Signaling and Tissue Fibrosis. , 2018, Cold Spring Harbor perspectives in biology.

[20]  Qiuyun Chen,et al.  A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure , 2017, Nature Communications.

[21]  Chunyan Luo,et al.  Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[22]  M. Davies,et al.  “In situ” endografting in the treatment of arterial and graft infections , 2017, Journal of vascular surgery.

[23]  Qiuyun Chen,et al.  Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury , 2017, Journal of the American Heart Association.

[24]  Yuan Liu,et al.  Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium , 2017, BMC Pulmonary Medicine.

[25]  H. Takagi,et al.  Association of Hypertension with Abdominal Aortic Aneurysm Expansion. , 2017, Annals of vascular surgery.

[26]  A. Hinck,et al.  Structural Biology and Evolution of the TGF-β Family. , 2016, Cold Spring Harbor perspectives in biology.

[27]  Qiuyun Chen,et al.  Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin. , 2016, Human molecular genetics.

[28]  Qiuyun Chen,et al.  Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease , 2016, PLoS biology.

[29]  J. Lindholt,et al.  Baseline prevalence of abdominal aortic aneurysm, peripheral arterial disease and hypertension in men aged 65–74 years from a population screening study (VIVA trial) , 2015, The British journal of surgery.

[30]  Javariah Fatima,et al.  Treatment and outcomes of aortic endograft infection. , 2015, Journal of vascular surgery.

[31]  T. Luebke,et al.  Risk-Adjusted Meta-analysis of 30-Day Mortality of Endovascular Versus Open Repair for Ruptured Abdominal Aortic Aneurysms. , 2015, Annals of vascular surgery.

[32]  R. Hynes,et al.  &agr;5 and &agr;v integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo , 2015, Journal of Cell Science.

[33]  R. Hynes,et al.  α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo , 2015, Development.

[34]  Chengqi Xu,et al.  Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. , 2014, Blood.

[35]  D. Milewicz,et al.  Aortic Remodeling After Transverse Aortic Constriction in Mice Is Attenuated With AT1 Receptor Blockade , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[36]  N. de Las Heras,et al.  Pathophysiology of Vascular Remodeling in Hypertension , 2013, International journal of hypertension.

[37]  Qiuyun Chen,et al.  MOG1 Rescues Defective Trafficking of Nav1.5 Mutations in Brugada Syndrome and Sick Sinus Syndrome , 2013, Circulation. Arrhythmia and electrophysiology.

[38]  X. Tu,et al.  Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. , 2013, Human molecular genetics.

[39]  J Zhang,et al.  Angiogenic Factor AGGF1 Promotes Therapeutic Angiogenesis in a Mouse Limb Ischemia Model , 2012, PloS one.

[40]  K. Kossen,et al.  Antifibrotic activities of pirfenidone in animal models , 2011, European Respiratory Review.

[41]  D. Judge,et al.  Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism , 2011, Science.

[42]  Qing Yang,et al.  Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population , 2011, Nature Genetics.

[43]  A. Sonnenberg,et al.  Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healing , 2010, EMBO reports.

[44]  Marc K. Halushka,et al.  Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome , 2006, Science.

[45]  John A Elefteriades,et al.  Hyperplastic Cellular Remodeling of the Media in Ascending Thoracic Aortic Aneurysms , 2005, Circulation.

[46]  Jessica Geubtner,et al.  Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome. , 2004, The Journal of clinical investigation.

[47]  P. Szafranski,et al.  Identification of an angiogenic factor that when mutated causes susceptibility to Klippel–Trenaunay syndrome , 2004, Nature.

[48]  L. Schnapp,et al.  Integrin α8β1 mediates adhesion to LAP-TGFβ1 , 2002, Journal of Cell Science.

[49]  Ernesto L. Schiffrin,et al.  Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and Fibrosis , 2001, Hypertension.

[50]  S. Leeder,et al.  A population based study , 1993, The Medical journal of Australia.

[51]  M. Nataatmadja,et al.  Angiotensin II Receptor Antagonism Reduces Transforming Growth Factor Beta and Smad Signaling in Thoracic Aortic Aneurysm. , 2013, The Ochsner journal.

[52]  L. A. Anderson.  Abdominal aortic aneurysm. , 2001, The Journal of cardiovascular nursing.

[53]  Robert C. Wolpert,et al.  A Review of the , 1985 .