Hippocampus, fimbria-fornix, amygdala, and memory: object discriminations in rats.

Rats with lesions of the fimbria-fornix, hippocampus, or hippocampus and amygdala were tested in object discriminations commonly used with monkeys. Two 1-pair object discriminations were learned preoperatively and tested postoperatively. Additional postoperative testing included acquisition of a third 1-pair object discrimination, an 8-pair concurrent object discrimination, and spatial alternation. All lesions impaired performance in the 8-pair object discrimination and in spatial alternation but not in the 1-pair object discriminations. Data from this study and from previous studies indicate that the hippocampus in both rats and monkeys has an important role in the mnemonic processes required for concurrent object discriminations and that variations of the procedure for concurrent object discriminations can be an effective tool for investigating hippocampal function.

[1]  Larry R. Squire,et al.  CHAPTER 6 – THE NEUROLOGY OF MEMORY: THE CASE FOR CORRESPONDENCE BETWEEN THE FINDINGS FOR HUMAN AND NONHUMAN PRIMATE1 , 1983 .

[2]  S. Zola-Morgan,et al.  Hippocampal resections impair associative learning and recognition memory in the monkey , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[3]  M. Mishkin,et al.  Visual recognition in monkeys: effects of separate vs. combined transection of fornix and amygdalofugal pathways , 2004, Experimental Brain Research.

[4]  S. Zola-Morgan,et al.  Enhanced preference for perceptual novelty in the monkey after section of the fornix but not after ablation of the hippocampus , 1983, Neuropsychologia.

[5]  J. Orbach,et al.  Learning and retention in monkeys after amygdala-hippocampus resection. , 1960, Archives of neurology.

[6]  L. F. Kromer,et al.  Role of the parahippocampal region in spatial and non-spatial memory: Effects of parahippocampal lesions on rewarded alternation and concurrent object discrimination learning in the rat , 1993, Behavioural Brain Research.

[7]  M. Mishkin,et al.  The neuroanatomy of amnesia: amygdala-hippocampus versus temporal stem. , 1982, Science.

[8]  R. Sutherland,et al.  Configural association theory: The role of the hippocampal formation in learning, memory, and amnesia , 1989, Psychobiology.

[9]  M. Mishkin,et al.  Visual recognition in monkeys following rhinal cortical ablations combined with either amygdalectomy or hippocampectomy , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[10]  L. Rothblat,et al.  Short-term object recognition memory in the rat: nonmatching with trial-unique junk stimuli. , 1987, Behavioral neuroscience.

[11]  D. S. Olton,et al.  Effects of fornix transection and cingulate cortical ablation on spatial memory in rhesus monkeys , 2004, Experimental Brain Research.

[12]  Robert W. Kentridge,et al.  Lesions of the fornix but not the amygdala impair the acquisition of concurrent discriminations by rats , 1992, Behavioural Brain Research.

[13]  S. Zola-Morgan,et al.  Retention deficits after combined amygdalo-hippocampal and selective hippocampal resections in the monkey , 1981, Neuropsychologia.

[14]  S. Zola,et al.  A non-modality specific impairment in spatial learning after fornix lesions in monkeys. , 1973, Neuropsychologia.

[15]  S. Zola-Morgan,et al.  Concurrent discrimination learning of monkeys after hippocampal, entorhinal, or fornix lesions , 1981, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[16]  Joseph E LeDoux,et al.  Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[17]  L. F. Kromer,et al.  Object recognition memory in the rat: the role of the hippocampus , 1991, Behavioural Brain Research.

[18]  R. J. McDonald,et al.  Hippocampus, amygdala, and memory deficits in rats , 1990, Behavioural Brain Research.

[19]  D. Olton,et al.  Mnemonic Dissociations: The Power of Parameters , 1992, Journal of Cognitive Neuroscience.

[20]  M. Mishkin.  Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus , 1978, Nature.

[21]  J. Aggleton,et al.  Effects of amygdaloid and amygdaloid-hippocampal lesions on object recognition and spatial working memory in rats. , 1989, Behavioral neuroscience.

[22]  C. Barnes.  Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat , 1988, Trends in Neurosciences.

[23]  R. Sutherland,et al.  The hippocampal formation is necessary for rats to learn and remember configural discriminations , 1989, Behavioural Brain Research.

[24]  H. Mahut,et al.  A selective spatial deficit in monkeys after transection of the fornix. , 1972, Neuropsychologia.

[25]  F. Gage,et al.  Hippocampal connections and spatial discrimination , 1978, Brain Research.

[26]  L. Squire,et al.  Lesions of the amygdala that spare adjacent cortical regions do not impair memory or exacerbate the impairment following lesions of the hippocampal formation , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[27]  L R Squire,et al.  Lesions of the hippocampal formation but not lesions of the fornix or the mammillary nuclei produce long-lasting memory impairment in monkeys , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[28]  D. Olton,et al.  Hippocampal and amygdaloid involvement in working memory for nonspatial stimuli. , 1988, Behavioral neuroscience.

[29]  L. Nadel,et al.  The Hippocampus as a Cognitive Map , 1978 .

[30]  M. Mishkin,et al.  Limbic lesions and the problem of stimulus--reinforcement associations. , 1972, Experimental neurology.

[31]  S M Zola,et al.  Paradoxical facilitation of object reversal learning after transection of the fornix in monkeys. , 1973, Neuropsychologia.

[32]  J. Rawlins,et al.  Associations across time: The hippocampus as a temporary memory store , 1985, Behavioral and Brain Sciences.

[33]  D. Amaral,et al.  Lesions of perirhinal and parahippocampal cortex that spare the amygdala and hippocampal formation produce severe memory impairment , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[34]  J. A. Horel.  The neuroanatomy of amnesia. A critique of the hippocampal memory hypothesis. , 1978, Brain : a journal of neurology.

[35]  L. Squire,et al.  Preserved learning in monkeys with medial temporal lesions: sparing of motor and cognitive skills , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[36]  L. Squire,et al.  Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia. , 1985, Behavioral neuroscience.

[37]  J. A. Horel,et al.  The performance of visual tasks while segments of the inferotemporal cortex are suppressed by cold , 1987, Behavioural Brain Research.

[38]  G. Handelmann,et al.  Hippocampus, space, and memory , 1979 .

[39]  L. Squire,et al.  Preserved learning and retention of pattern-analyzing skill in amnesia: dissociation of knowing how and knowing that. , 1980, Science.

[40]  Douglas L. Rosene,et al.  The Hippocampal Formation of the Primate Brain , 1987 .

[41]  H Eichenbaum,et al.  Normal olfactory discrimination learning set and facilitation of reversal learning after medial-temporal damage in rats: implications for an account of preserved learning abilities in amnesia , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.