The effect of catechol‐O‐methyltransferase polymorphisms on pain is modified by depressive symptoms

Variations within the catechol‐O‐methyltransferase (COMT) gene have been associated with pain severity in temporomandibular disorders (TMDs). Psychological factors such as personal conflicts, life stress and depression, are well known to be associated with onset, severity and chronicity of pain disorders.

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