Nanobodies as therapeutics: big opportunities for small antibodies.
暂无分享,去创建一个
[1] G. Decavalas,et al. Severe Sepsis and Septic Shock , 2018 .
[2] Alexander K. Buell,et al. Vrije Universiteit Brussel Nanobodies Raised against Monomeric alpha-Synuclein Distinguish between Fibrils at Different Maturation Stages , 2017 .
[3] C. Vanhove,et al. Targeting of vascular cell adhesion molecule-1 by 18F-labelled nanobodies for PET/CT imaging of inflamed atherosclerotic plaques. , 2016, European heart journal cardiovascular Imaging.
[4] A. Kilcoyne,et al. Molecular imaging-its current role in cancer. , 2016, QJM : monthly journal of the Association of Physicians.
[5] Y. Saeys,et al. Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8. , 2016, Molecular therapy : the journal of the American Society of Gene Therapy.
[6] M. Rajabibazl,et al. Camelid‐derived heavy‐chain nanobody against Clostridium botulinum neurotoxin E in Pichia pastoris , 2016, Biotechnology and applied biochemistry.
[7] R. Schiffelers,et al. PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[8] C. Dullin,et al. In vivo detection of small tumour lesions by multi-pinhole SPECT applying a 99mTc-labelled nanobody targeting the Epidermal Growth Factor Receptor , 2016, Scientific Reports.
[9] H. Lyerly,et al. Preclinical Evaluation of 18F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET , 2016, The Journal of Nuclear Medicine.
[10] H. Ploegh,et al. Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma. , 2016, Angewandte Chemie.
[11] B. Jilma,et al. Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura. , 2016, The New England journal of medicine.
[12] Sabrina Oliveira,et al. Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization , 2016, EJNMMI Research.
[13] Melanie A. Huntley,et al. Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies , 2016, Neuron.
[14] C. Vanhove,et al. Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma , 2016, The Journal of Nuclear Medicine.
[15] M. Zalutsky,et al. Preclinical Evaluation of 18 F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by ImmunoPET , 2016 .
[16] R. Tao,et al. A Nanobody Activation Immunotherapeutic that Selectively Destroys HER2‐Positive Breast Cancer Cells , 2016, Chembiochem : a European journal of chemical biology.
[17] E. Zhou,et al. An intracellularly expressed Nsp9-specific nanobody in MARC-145 cells inhibits porcine reproductive and respiratory syndrome virus replication. , 2015, Veterinary microbiology.
[18] A. de Marco,et al. Nanobody-functionalized PEG-b-PCL polymersomes and their targeting study. , 2015, Journal of biotechnology.
[19] W. Mali,et al. Hypoxia-Targeting Fluorescent Nanobodies for Optical Molecular Imaging of Pre-Invasive Breast Cancer , 2015, Molecular Imaging and Biology.
[20] Jonathan S. Mason,et al. Structures of G protein-coupled receptors reveal new opportunities for drug discovery. , 2015, Drug discovery today.
[21] C. Palomo,et al. Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection , 2015, Antimicrobial Agents and Chemotherapy.
[22] N. Mantis,et al. Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies* , 2015, The Journal of Biological Chemistry.
[23] Baorui Liu,et al. A tumor-penetrating recombinant protein anti-EGFR-iRGD enhance efficacy of paclitaxel in 3D multicellular spheroids and gastric cancer in vivo. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[24] K. Bok,et al. Llama Nanoantibodies with Therapeutic Potential against Human Norovirus Diarrhea , 2015, PloS one.
[25] Michel Goedert,et al. Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein , 2015, Science.
[26] Guy Bormans,et al. PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments , 2015, The Journal of Nuclear Medicine.
[27] A. González-Techera,et al. Increasing the potency of neutralizing single-domain antibodies by functionalization with a CD11b/CD18 binding domain , 2015, mAbs.
[28] G. Koning,et al. A Novel 111In-Labeled Anti–Prostate-Specific Membrane Antigen Nanobody for Targeted SPECT/CT Imaging of Prostate Cancer , 2015, The Journal of Nuclear Medicine.
[29] B. Strukelj,et al. Non-immunoglobulin scaffolds: a focus on their targets. , 2015, Trends in biotechnology.
[30] Yanli Guo,et al. Ultrasonic Nanobubbles Carrying Anti-PSMA Nanobody: Construction and Application in Prostate Cancer-Targeted Imaging , 2015, PloS one.
[31] M. Rajabibazl,et al. Production of Novel VHH Nanobody Inhibiting Angiogenesis by Targeting Binding Site of VEGF , 2015, Applied Biochemistry and Biotechnology.
[32] M. Cristina Cardoso,et al. Nanobodies and recombinant binders in cell biology , 2015, The Journal of cell biology.
[33] I. Nabiev,et al. Detection of carcinoembryonic antigen using single-domain or full-size antibodies stained with quantum dot conjugates. , 2015, Analytical biochemistry.
[34] P. Skottrup,et al. Selection and characterization of camelid nanobodies towards urokinase-type plasminogen activator. , 2015, Molecular immunology.
[35] H. D. de Koning,et al. Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis , 2015, PLoS pathogens.
[36] B. '. ’t Hart,et al. The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis , 2015, Arthritis Research & Therapy.
[37] Yakun Wan,et al. Characterization and applications of Nanobodies against human procalcitonin selected from a novel naïve Nanobody phage display library , 2015, Journal of Nanobiotechnology.
[38] Ralph Weissleder,et al. Noninvasive imaging of immune responses , 2015, Proceedings of the National Academy of Sciences.
[39] Min Wu,et al. A novel nanobody specific for respiratory surfactant protein A has potential for lung targeting , 2015, International journal of nanomedicine.
[40] M. Dumoulin,et al. Camelid single-domain antibody fragments: Uses and prospects to investigate protein misfolding and aggregation, and to treat diseases associated with these phenomena. , 2015, Biochimie.
[41] P. Srimanote,et al. Humanized-VHH Transbodies that Inhibit HCV Protease and Replication , 2015, Viruses.
[42] A. Desmyter,et al. Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody , 2015, PloS one.
[43] Lei Chen,et al. CD4 binding site broadly neutralizing antibody selection of HIV-1 escape mutants. , 2015, The Journal of general virology.
[44] Baorui Liu,et al. Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy. , 2015, Journal of controlled release : official journal of the Controlled Release Society.
[45] K. Papadopoulos,et al. Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor , 2015, Cancer Chemotherapy and Pharmacology.
[46] E. Pardon,et al. Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies , 2015, Veterinary Research.
[47] S. Muyldermans,et al. Monitoring liver macrophages using nanobodies targeting Vsig4: concanavalin A induced acute hepatitis as paradigm. , 2015, Immunobiology.
[48] S. Charlton,et al. Potent and Efficacious Inhibition of CXCR2 Signaling by Biparatopic Nanobodies Combining Two Distinct Modes of Action , 2015, Molecular Pharmacology.
[49] S. Hussain,et al. Description of a Nanobody-based Competitive Immunoassay to Detect Tsetse Fly Exposure , 2015, PLoS neglected tropical diseases.
[50] Asher Mullard. 2014 FDA drug approvals , 2015, Nature Reviews Drug Discovery.
[51] S. Achilefu,et al. Small Sized EGFR1 and HER2 Specific Bifunctional Antibody for Targeted Cancer Therapy , 2015, Theranostics.
[52] H. Rohde,et al. Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT , 2015, Scientific Reports.
[53] S. Oliveira,et al. Nanobody-based cancer therapy of solid tumors. , 2015, Nanomedicine.
[54] W. Derave,et al. An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model. , 2015, Human molecular genetics.
[55] Miguel Soriano,et al. Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis. , 2015, Journal of controlled release : official journal of the Controlled Release Society.
[56] S. Leppla,et al. A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model* , 2015, The Journal of Biological Chemistry.
[57] F. Koch-Nolte,et al. ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells. , 2015, Current topics in microbiology and immunology.
[58] G. Norata,et al. HDL in infectious diseases and sepsis. , 2015, Handbook of experimental pharmacology.
[59] Michelle E. Hung,et al. Designed Ankyrin Repeat Proteins ( DARPins ) : Binding Proteins for Research , Diagnostics , and Therapy , 2015 .
[60] B. Devreese,et al. Generation of a Nanobody Targeting the Paraflagellar Rod Protein of Trypanosomes , 2014, PloS one.
[61] H. Ploegh,et al. Intracellular Expression of Camelid Single-Domain Antibodies Specific for Influenza Virus Nucleoprotein Uncovers Distinct Features of Its Nuclear Localization , 2014, Journal of Virology.
[62] Martine De Vos,et al. Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1* , 2014, The Journal of Biological Chemistry.
[63] Yakun Wan,et al. Streptavidin-biotin-based directional double Nanobody sandwich ELISA for clinical rapid and sensitive detection of influenza H5N1 , 2014, Journal of Translational Medicine.
[64] G. Hansman,et al. Nanobody Binding to a Conserved Epitope Promotes Norovirus Particle Disassembly , 2014, Journal of Virology.
[65] E. Pardon,et al. Nanobody Mediated Inhibition of Attachment of F18 Fimbriae Expressing Escherichia coli , 2014, PloS one.
[66] B. Gamain,et al. Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain , 2014, Scientific Reports.
[67] E. Vanstreels,et al. A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity. , 2014, Antiviral research.
[68] Robin A. Weiss,et al. Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1 , 2014, PLoS pathogens.
[69] G. Caljon,et al. Delivery of a functional anti-trypanosome Nanobody in different tsetse fly tissues via a bacterial symbiont, Sodalis glossinidius , 2014, Microbial Cell Factories.
[70] J. Eldredge,et al. A novel platform for engineering blood‐brain barrier‐crossing bispecific biologics , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[71] I. Nabiev,et al. Multiphoton imaging of tumor biomarkers with conjugates of single-domain antibodies and quantum dots. , 2014, Nanomedicine : nanotechnology, biology, and medicine.
[72] Julia Maier,et al. Recent progress in generating intracellular functional antibody fragments to target and trace cellular components in living cells. , 2014, Biochimica et biophysica acta.
[73] W. Sellers,et al. Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction , 2014, mAbs.
[74] G. van Ommen,et al. Selection and characterization of llama single domain antibodies against N-terminal huntingtin , 2014, Neurological Sciences.
[75] Sabrina Oliveira,et al. Nanobody-photosensitizer conjugates for targeted photodynamic therapy. , 2014, Nanomedicine : nanotechnology, biology, and medicine.
[76] Gilles Barone-Rochette,et al. 99mTc-cAbVCAM1-5 Imaging Is a Sensitive and Reproducible Tool for the Detection of Inflamed Atherosclerotic Lesions in Mice , 2014, The Journal of Nuclear Medicine.
[77] B. Aggarwal. Editorial: Balancing Tumor Necrosis Factor Receptor I and Tumor Necrosis Factor Receptor II Jointly for Joint Inflammation , 2014, Arthritis & rheumatology.
[78] E. Lerma,et al. Thrombotic thrombocytopenic purpura. , 2014, Disease-a-month : DM.
[79] J. Vandekerckhove,et al. Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model. , 2014, Molecular therapy : the journal of the American Society of Gene Therapy.
[80] M. Fink,et al. Strategies to improve drug development for sepsis , 2014, Nature Reviews Drug Discovery.
[81] J. Tommassen,et al. Inhibition of biofilm formation by Camelid single-domain antibodies against the flagellum of Pseudomonas aeruginosa. , 2014, Journal of biotechnology.
[82] Yakun Wan,et al. Combining magnetic nanoparticle with biotinylated nanobodies for rapid and sensitive detection of influenza H3N2 , 2014, Nanoscale Research Letters.
[83] F. Koch-Nolte,et al. Nanobodies as modulators of inflammation: potential applications for acute brain injury , 2014, Front. Cell. Neurosci..
[84] S. Muyldermans,et al. Interactions between Metal-binding Domains Modulate Intracellular Targeting of Cu(I)-ATPase ATP7B, as Revealed by Nanobody Binding* , 2014, The Journal of Biological Chemistry.
[85] R. Stábeli,et al. Novel Camelid Antibody Fragments Targeting Recombinant Nucleoprotein of Araucaria hantavirus: A Prototype for an Early Diagnosis of Hantavirus Pulmonary Syndrome , 2014, PloS one.
[86] D. Schmidt,et al. A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice. , 2014, The Journal of infectious diseases.
[87] N. Iqbal,et al. Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications , 2014, Molecular biology international.
[88] D. Curiel,et al. Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein , 2014, PloS one.
[89] M. Rudolph,et al. Crystal structures of ricin toxin's enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies. , 2014, Journal of molecular biology.
[90] S. Muyldermans,et al. Radiolabeled nanobodies as theranostic tools in targeted radionuclide therapy of cancer , 2014, Expert opinion on drug delivery.
[91] M. Tayebi,et al. Potential candidate camelid antibodies for the treatment of protein-misfolding diseases , 2014, Journal of Neuroimmunology.
[92] T. Baral,et al. In vivo imaging of brain cancer using epidermal growth factor single domain antibody bioconjugated to near-infrared quantum dots. , 2014, Journal of nanoscience and nanotechnology.
[93] S. Muyldermans,et al. A nanobody-based electrochemiluminescent immunosensor for sensitive detection of human procalcitonin. , 2014, The Analyst.
[94] N. Devoogdt,et al. Camelid reporter gene imaging: a generic method for in vivo cell tracking , 2014, EJNMMI Research.
[95] H. Walczak,et al. Getting TRAIL back on track for cancer therapy , 2014, Cell Death and Differentiation.
[96] S. Maier,et al. Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in lung and breast cancer cells. , 2014, ACS nano.
[97] N. Mantis,et al. Differential Neutralizing Activities of a Single Domain Camelid Antibody (VHH) Specific for Ricin Toxin’s Binding Subunit (RTB) , 2014, PloS one.
[98] S. Muyldermans,et al. A camelid antibody candidate for development of a therapeutic agent against Hemiscorpius lepturus envenomation , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[99] K. van Beneden,et al. FRI0329 Impact of Clinical Remission on Physical Function in Patients with Rheumatoid Arthritis Treated with Alx-0061: Post-Hoc Analysis of Phase I/Ii Data , 2014 .
[100] A. Vahrmeijer,et al. Intraoperative fluorescence delineation of head and neck cancer with a fluorescent Anti‐epidermal growth factor receptor nanobody , 2014, International journal of cancer.
[101] A. Riazi,et al. Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility. , 2014, Protein engineering, design & selection : PEDS.
[102] S. Muyldermans,et al. Site-specific labeling of cysteine-tagged camelid single-domain antibody-fragments for use in molecular imaging. , 2014, Bioconjugate chemistry.
[103] M. Smit,et al. GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeutics. , 2014, Trends in pharmacological sciences.
[104] S. Muyldermans,et al. Nanobody-based products as research and diagnostic tools. , 2014, Trends in biotechnology.
[105] S. Muyldermans,et al. Generation and characterization of nanobodies targeting PSMA for molecular imaging of prostate cancer. , 2014, Contrast media & molecular imaging.
[106] S. Muyldermans,et al. Molecular Imaging with Macrophage CRIg-Targeting Nanobodies for Early and Preclinical Diagnosis in a Mouse Model of Rheumatoid Arthritis , 2014, The Journal of Nuclear Medicine.
[107] L. Hammarström,et al. Co-Expression of Anti-Rotavirus Proteins (Llama VHH Antibody Fragments) in Lactobacillus: Development and Functionality of Vectors Containing Two Expression Cassettes in Tandem , 2014, PloS one.
[108] S. Muyldermans,et al. Targeted Radionuclide Therapy with A 177Lu-labeled Anti-HER2 Nanobody , 2014, Theranostics.
[109] C. Dobson,et al. Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies , 2014, Acta neuropathologica communications.
[110] H. Kiyono,et al. A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. , 2014, Journal of biotechnology.
[111] S. Muyldermans,et al. Specific Targeting of Atherosclerotic Plaques in ApoE−/− Mice Using a New Camelid sdAb Binding the Vulnerable Plaque Marker LOX-1 , 2014, Molecular Imaging and Biology.
[112] H. Lyerly,et al. Improved Tumor Targeting of Anti-HER2 Nanobody Through N-Succinimidyl 4-Guanidinomethyl-3-Iodobenzoate Radiolabeling , 2014, The Journal of Nuclear Medicine.
[113] D. Ahmadvand,et al. A nanobody directed to a functional epitope on VEGF, as a novel strategy for cancer treatment. , 2014, Biochemical and biophysical research communications.
[114] G. Adam,et al. In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies. , 2014, Contrast media & molecular imaging.
[115] S. Muyldermans,et al. A general protocol for the generation of Nanobodies for structural biology , 2014, Nature Protocols.
[116] F. Koch-Nolte,et al. Technical Advance: A new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells , 2014, Journal of leukocyte biology.
[117] J. Tavernier,et al. The Anti-Tumor Activity of a Neutralizing Nanobody Targeting Leptin Receptor in a Mouse Model of Melanoma , 2014, PloS one.
[118] D. Filman,et al. Mechanism of Action and Capsid-Stabilizing Properties of VHHs with an In Vitro Antipolioviral Activity , 2014, Journal of Virology.
[119] M. Rajabibazl,et al. Functional Mutations in and Characterization of VHH Against Helicobacter pylori Urease , 2014, Applied Biochemistry and Biotechnology.
[120] I. Rasooli,et al. Immunoreaction of a recombinant nanobody from camelid single domain antibody fragment with Acinetobacter baumannii. , 2014, Transactions of the Royal Society of Tropical Medicine and Hygiene.
[121] S. Muyldermans,et al. Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies , 2014, Leukemia.
[122] Rubel Chakravarty,et al. Nanobody: The “Magic Bullet” for Molecular Imaging? , 2014, Theranostics.
[123] N. Harris,et al. The heavy chain diseases: clinical and pathologic features. , 2014, Oncology.
[124] J. Tavernier,et al. High efficiency cell-specific targeting of cytokine activity , 2014, Nature Communications.
[125] Giuseppe Legname,et al. Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody. , 2014, Journal of the American Chemical Society.
[126] Xiaomin Wang,et al. Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor , 2014, Scientific Reports.
[127] F. Lavorini,et al. Inhaler technique and patient's preference for dry powder inhaler devices , 2014, Expert opinion on drug delivery.
[128] E. Pardon,et al. Probing the N-Terminal beta-Sheet Conversion in the Crystal Structure of the Human Prion Protein Bound to a Nanobody Abskharon, , 2014 .
[129] G. Farrington,et al. Engineering and pharmacology of blood-brain barrier-permeable bispecific antibodies. , 2014, Advances in pharmacology.
[130] M. Shokrgozar,et al. T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: towards tumor-directed oligoclonal T cell therapy. , 2014, Biochimica et biophysica acta.
[131] B. Aggarwal. Balancing TNFR 1 and TNFR 2 Jointly for Joint Inflammation , 2014 .
[132] W. Hennink,et al. Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles. , 2014, Biomaterials.
[133] S. Benichou,et al. Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody , 2014, Retrovirology.
[134] C. Szymanski,et al. Pentavalent Single-Domain Antibodies Reduce Campylobacter jejuni Motility and Colonization in Chickens , 2013, PloS one.
[135] Sabrina Oliveira,et al. Targeting tumors with nanobodies for cancer imaging and therapy. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[136] O. De Wever,et al. A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis , 2013, Breast Cancer Research.
[137] N. Mantis,et al. Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin* , 2013, The Journal of Biological Chemistry.
[138] T. Standal,et al. Anti‐c‐MET Nanobody® – a new potential drug in multiple myeloma treatment , 2013, European journal of haematology.
[139] N. Levy,et al. Preferential Lentiviral Targeting of Astrocytes in the Central Nervous System , 2013, PloS one.
[140] L. Hammarström,et al. Anti-rotavirus protein reduces stool output in infants with diarrhea: a randomized placebo-controlled trial. , 2013, Gastroenterology.
[141] S. Tzipori,et al. A Single VHH-Based Toxin-Neutralizing Agent and an Effector Antibody Protect Mice against Challenge with Shiga Toxins 1 and 2 , 2013, Infection and Immunity.
[142] K. Omidfar,et al. Efficient growth inhibition of EGFR over-expressing tumor cells by an anti-EGFR nanobody , 2013, Molecular Biology Reports.
[143] M. Oyama,et al. Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. , 2013, The Journal of clinical investigation.
[144] M. Buyse,et al. ALX-0962, an anti-IgE Nanobody® with a dual mode of action , 2013 .
[145] M. R. Bazl,et al. A novel nanobody against urease activity of Helicobacter pylori. , 2013, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
[146] A. Meola,et al. An alpaca nanobody inhibits hepatitis C virus entry and cell‐to‐cell transmission , 2013, Hepatology.
[147] G. V. van Dongen,et al. Llama-derived Single Variable Domains (Nanobodies) Directed against Chemokine Receptor CXCR7 Reduce Head and Neck Cancer Cell Growth in Vivo , 2013, The Journal of Biological Chemistry.
[148] C. Verlinde,et al. The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody. , 2013, Molecular and biochemical parasitology.
[149] Carla P. Guimarães,et al. Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions , 2013, Nature Protocols.
[150] Alexander K. Buell,et al. Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. , 2013, Journal of molecular biology.
[151] Michael D. McLean,et al. In Vivo Neutralization of α-Cobratoxin with High-Affinity Llama Single-Domain Antibodies (VHHs) and a VHH-Fc Antibody , 2013, PloS one.
[152] P. De Baetselier,et al. Targeting of Human Antigen-Presenting Cell Subsets , 2013, Journal of Virology.
[153] S. Muyldermans,et al. Camelid single-domain antibody-fragment engineering for (pre)clinical in vivo molecular imaging applications: adjusting the bullet to its target , 2013, Expert opinion on biological therapy.
[154] A. Serone,et al. Autoantibodies to Variable Heavy (VH) Chain Ig Sequences in Humans Impact the Safety and Clinical Pharmacology of a VH Domain Antibody Antagonist of TNF-α Receptor 1 , 2013, Journal of Clinical Immunology.
[155] S. Muyldermans,et al. V(H)H (nanobody) directed against human glycophorin A: a tool for autologous red cell agglutination assays. , 2013, Analytical biochemistry.
[156] W. Leenders,et al. Nanobody-functionalized polymersomes for tumor-vessel targeting. , 2013, Macromolecular bioscience.
[157] M. Shokrgozar,et al. Genetically engineered T cells bearing chimeric nanoconstructed receptors harboring TAG-72-specific camelid single domain antibodies as targeting agents. , 2013, Cancer letters.
[158] Sam Millet,et al. Orally fed seeds producing designer IgAs protect weaned piglets against enterotoxigenic Escherichia coli infection , 2013, Proceedings of the National Academy of Sciences.
[159] Vasilis Ntziachristos,et al. Rapid optical imaging of human breast tumour xenografts using anti-HER2 VHHs site-directly conjugated to IRDye 800CW for image-guided surgery , 2013, European Journal of Nuclear Medicine and Molecular Imaging.
[160] B. Robert,et al. Single-Domain Antibody–Based and Linker-Free Bispecific Antibodies Targeting FcγRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells , 2013, Molecular Cancer Therapeutics.
[161] G. Xiao,et al. Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics , 2013, International journal of cell biology.
[162] Serge Muyldermans,et al. Nanobodies: natural single-domain antibodies. , 2013, Annual review of biochemistry.
[163] J. Holz,et al. Anti-RANKL nanobody ALX-0141 shows sustained biomarker inhibition in a Phase I study in healthy postmenopausal Women , 2013 .
[164] A. Messer,et al. Intrabodies as Neuroprotective Therapeutics , 2013, Neurotherapeutics.
[165] E. Brunette,et al. Multiplexed evaluation of serum and CSF pharmacokinetics of brain-targeting single-domain antibodies using a NanoLC-SRM-ILIS method. , 2013, Molecular pharmaceutics.
[166] Marleen Keyaerts,et al. Synthesis, Preclinical Validation, Dosimetry, and Toxicity of 68Ga-NOTA-Anti-HER2 Nanobodies for iPET Imaging of HER2 Receptor Expression in Cancer , 2013, The Journal of Nuclear Medicine.
[167] P. De Baetselier,et al. SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis , 2013, The Journal of Nuclear Medicine.
[168] Imre Mäger,et al. Extracellular vesicles: biology and emerging therapeutic opportunities , 2013, Nature Reviews Drug Discovery.
[169] L. Sherwood,et al. Ebolavirus Nucleoprotein C-Termini Potently Attract Single Domain Antibodies Enabling Monoclonal Affinity Reagent Sandwich Assay (MARSA) Formulation , 2013, PloS one.
[170] E. Vanstreels,et al. Mapping the Binding Interface between an HIV-1 Inhibiting Intrabody and the Viral Protein Rev , 2013, PloS one.
[171] T. I. Ivanova,et al. Formatted single-domain antibodies can protect mice against infection with influenza virus (H5N2). , 2013, Antiviral research.
[172] C. Kuan,et al. Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood–brain barrier , 2013, Proceedings of the National Academy of Sciences.
[173] W. Hennink,et al. Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[174] S. Muyldermans,et al. Development of VEGFR2-specific Nanobody Pseudomonas exotoxin A conjugated to provide efficient inhibition of tumor cell growth. , 2013, New biotechnology.
[175] W. Wijns,et al. Novel Antiplatelet Agents: ALX-0081, a Nanobody Directed towards von Willebrand Factor , 2013, Journal of Cardiovascular Translational Research.
[176] N. Devoogdt,et al. Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody. , 2013, Nuclear medicine and biology.
[177] S. Kiuru-Enari,et al. Hereditary gelsolin amyloidosis. , 2013, Handbook of clinical neurology.
[178] K. Ulbrich,et al. Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy. , 2013, Biomaterials.
[179] M. Rajabibazl,et al. A novel VHH nanobody against the active site (the CA domain) of tumor-associated, carbonic anhydrase isoform IX and its usefulness for cancer diagnosis , 2013, Biotechnology Letters.
[180] S. Muyldermans,et al. Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies , 2012, PLoS neglected tropical diseases.
[181] J. Holz,et al. Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura. , 2012, Blood.
[182] S. Muyldermans,et al. Pre-clinical studies of toxin-specific nanobodies: evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming. , 2012, Toxicology and applied pharmacology.
[183] M. V. Roy,et al. preclinical Development of Alx-0061, an Anti-il-6r Nanobody® for therapeutic Use in Rheumatoid Arthritis with a High in Vitro Affinity and Potency and a Competitive in Vivo Pharmacological Profile. : 336 , 2012 .
[184] J. Bourgeois,et al. Cell‐penetrating anti‐GFAP VHH and corresponding fluorescent fusion protein VHH‐GFP spontaneously cross the blood‐brain barrier and specifically recognize astrocytes: application to brain imaging , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[185] H. Wakimoto,et al. Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects , 2012, Proceedings of the National Academy of Sciences.
[186] Yi Huang,et al. Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion , 2012, BMC Biotechnology.
[187] S. Zeinali,et al. Expression, purification, and characterization of a diabody against the most important angiogenesis cell receptor: Vascular endothelial growth factor receptor 2 , 2012, Advanced biomedical research.
[188] C. López-Otín,et al. Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood–CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases , 2012, The Journal of Neuroscience.
[189] P. De Baetselier,et al. Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages. , 2012, Cancer research.
[190] M. van Buchem,et al. In Vivo Detection of Amyloid-\(\beta \) Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease , 2012 .
[191] Susan Y. Smith,et al. ALX-0141, an anti-rank-L targeting nanobody®, increases bone mass in cynomolgus monkeys , 2012 .
[192] Igor Nabiev,et al. Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes. , 2012, Nanomedicine : nanotechnology, biology, and medicine.
[193] I. Velikyan. Molecular Imaging and Radiotherapy: Theranostics for Personalized Patient Management , 2012, Theranostics.
[194] W. Hennink,et al. Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[195] Y. Michotte,et al. Using microdialysis to analyse the passage of monovalent nanobodies through the blood–brain barrier , 2012, British journal of pharmacology.
[196] Jakub Toczek,et al. Nanobodies Targeting Mouse/Human VCAM1 for the Nuclear Imaging of Atherosclerotic Lesions , 2012, Circulation research.
[197] Jakub Toczek,et al. Nanobody-coupled microbubbles as novel molecular tracer. , 2012, Journal of controlled release : official journal of the Controlled Release Society.
[198] J. Bouma,et al. In Vitro Neutralisation of Rotavirus Infection by Two Broadly Specific Recombinant Monovalent Llama-Derived Antibody Fragments , 2012, PloS one.
[199] P. De Baetselier,et al. Expression and extracellular release of a functional anti-trypanosome Nanobody® in Sodalis glossinidius, a bacterial symbiont of the tsetse fly , 2012, Microbial Cell Factories.
[200] G. Sinha. Ablynx drops lead nanobody , 2012, Nature Biotechnology.
[201] H. Wong. Clinical review: Sepsis and septic shock - the potential of gene arrays , 2012, Critical Care.
[202] G. V. van Dongen,et al. Nanobodies Targeting the Hepatocyte Growth Factor: Potential New Drugs for Molecular Cancer Therapy , 2012, Molecular Cancer Therapeutics.
[203] H. Wong,et al. A novel role for matrix metalloproteinase-8 in sepsis* , 2012, Critical care medicine.
[204] A. Kossiakoff,et al. Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo. , 2012, Bioconjugate chemistry.
[205] P. De Baetselier,et al. Development of the Nanobody display technology to target lentiviral vectors to antigen-presenting cells , 2012, Gene Therapy.
[206] W. Mali,et al. Rapid Visualization of Human Tumor Xenografts through Optical Imaging with a Near-Infrared Fluorescent Anti–Epidermal Growth Factor Receptor Nanobody , 2012, Molecular imaging.
[207] D. Dimitrov,et al. Expression, purification, and characterization of engineered antibody CH2 and VH domains. , 2012, Methods in molecular biology.
[208] B. Bouhaouala-Zahar,et al. Efficient expression of the anti‐AahI' scorpion toxin nanobody under a new functional form in a Pichia pastoris system , 2012, Biotechnology and applied biochemistry.
[209] A. de Marco,et al. Preparation of a naïve library of camelid single domain antibodies. , 2012, Methods in molecular biology.
[210] Michaela Gebauer,et al. Anticalins small engineered binding proteins based on the lipocalin scaffold. , 2012, Methods in enzymology.
[211] J. Tavernier,et al. Selection of non-competitive leptin antagonists using a random nanobody-based approach. , 2012, The Biochemical journal.
[212] N. Devoogdt,et al. Immuno-imaging using nanobodies. , 2011, Current opinion in biotechnology.
[213] R. Kontermann,et al. Strategies for extended serum half-life of protein therapeutics. , 2011, Current opinion in biotechnology.
[214] B. Schepens,et al. Nanobodies®: new ammunition to battle viruses. , 2011, Antiviral research.
[215] J. Tanha,et al. Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability , 2011, PloS one.
[216] B. Hyman,et al. Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging , 2011, Proceedings of the National Academy of Sciences.
[217] D. Ahmadvand,et al. Nanobody-based chimeric receptor gene integration in Jurkat cells mediated by φC31 integrase. , 2011, Experimental cell research.
[218] A. Verkleij,et al. A biparatopic anti‐EGFR nanobody efficiently inhibits solid tumour growth , 2011, International journal of cancer.
[219] R. Vandenbroucke,et al. Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1. , 2011, Cytokine & growth factor reviews.
[220] S. Muyldermans,et al. Evaluation of a nanobody phage display library constructed from a Brucella-immunised camel. , 2011, Veterinary immunology and immunopathology.
[221] Nick Devoogdt,et al. Preclinical screening of anti‐HER2 nanobodies for molecular imaging of breast cancer , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[222] Liesbet Lagae,et al. Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy. , 2011, ACS nano.
[223] A. Marco. Biotechnological applications of recombinant single-domain antibody fragments , 2011 .
[224] A. de Marco. Biotechnological applications of recombinant single-domain antibody fragments , 2011, Microbial cell factories.
[225] Mark C. Field,et al. High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis , 2011, PLoS pathogens.
[226] Deming Zhao,et al. PrPSc-Specific Antibodies with the Ability to Immunodetect Prion Oligomers , 2011, PloS one.
[227] L. Hammarström,et al. Lactobacilli producing bispecific llama-derived anti-rotavirus proteins in vivo for rotavirus-induced diarrhea. , 2011, Future microbiology.
[228] U. Tuor,et al. Small unilamellar vesicles: a platform technology for molecular imaging of brain tumors , 2011, Nanotechnology.
[229] R. Weiss,et al. Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection. , 2011, The Journal of infectious diseases.
[230] X. Breakefield,et al. Genetic therapy for the nervous system. , 2011, Human molecular genetics.
[231] R. Vandenbroucke,et al. Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression. , 2011, Cytokine & growth factor reviews.
[232] R. Weiss,et al. Llama-Derived Single Domain Antibodies to Build Multivalent, Superpotent and Broadened Neutralizing Anti-Viral Molecules , 2011, PloS one.
[233] E. Véscovi,et al. Single‐domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP‐ribosylating toxin of Salmonella typhimurium , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[234] K. K. Andersen,et al. Integrative Expression System for Delivery of Antibody Fragments by Lactobacilli , 2011, Applied and Environmental Microbiology.
[235] L. Wyns,et al. Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant , 2011, Proceedings of the National Academy of Sciences of the United States of America.
[236] J. Tanha,et al. Neutralization of Clostridium difficile Toxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain* , 2011, The Journal of Biological Chemistry.
[237] Pin Wang,et al. Immunization delivered by lentiviral vectors for cancer and infectious diseases , 2011, Immunological reviews.
[238] G. V. van Dongen,et al. Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET , 2011, European Journal of Nuclear Medicine and Molecular Imaging.
[239] S. Muyldermans,et al. Direct Injection of Functional Single-Domain Antibodies from E. coli into Human Cells , 2010, PloS one.
[240] R. Leurs,et al. CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells , 2010, Proceedings of the National Academy of Sciences.
[241] C. Dobson,et al. Structure and properties of a complex of α-synuclein and a single-domain camelid antibody. , 2010, Journal of molecular biology.
[242] S. Muyldermans,et al. A bispecific nanobody to provide full protection against lethal scorpion envenoming , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[243] G. Schreiber,et al. Cytokine-receptor interactions as drug targets. , 2010, Current opinion in chemical biology.
[244] R. Schiffelers,et al. Downregulation of EGFR by a novel multivalent nanobody-liposome platform. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[245] M. During,et al. Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition , 2010, Cell.
[246] S. Muyldermans,et al. In Vitro Analysis and In Vivo Tumor Targeting of a Humanized, Grafted Nanobody in Mice Using Pinhole SPECT/Micro-CT , 2010, Journal of Nuclear Medicine.
[247] Rachael D. Bernstein,et al. Llama-derived single-domain antibodies for the detection of botulinum A neurotoxin , 2010, Analytical and bioanalytical chemistry.
[248] Fredrik Y Frejd,et al. Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications , 2010, FEBS letters.
[249] Anna M Wu,et al. Antibody vectors for imaging. , 2010, Seminars in nuclear medicine.
[250] S. Muyldermans,et al. Nanobodies as Tools for In Vivo Imaging of Specific Immune Cell Types , 2010, Journal of Nuclear Medicine.
[251] E. Vanstreels,et al. An Intrabody Based on a Llama Single-domain Antibody Targeting the N-terminal α-Helical Multimerization Domain of HIV-1 Rev Prevents Viral Production* , 2010, The Journal of Biological Chemistry.
[252] R. Weiss,et al. Generation of a Family-specific Phage Library of Llama Single Chain Antibody Fragments That Neutralize HIV-1* , 2010, The Journal of Biological Chemistry.
[253] Diarmaid Hughes,et al. Antibiotic resistance and its cost: is it possible to reverse resistance? , 2010, Nature Reviews Microbiology.
[254] C. Bate,et al. A Camelid Anti-PrP Antibody Abrogates PrPSc Replication in Prion-Permissive Neuroblastoma Cell Lines , 2010, PloS one.
[255] M. Jaramillo,et al. Differential tumor-targeting abilities of three single-domain antibody formats. , 2010, Cancer letters.
[256] F. Koch-Nolte,et al. A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. , 2010, Journal of autoimmunity.
[257] E. Remaut,et al. Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis , 2010, Mucosal Immunology.
[258] A. Kondo,et al. Biotinylated bionanocapsules for displaying diverse ligands toward cell-specific delivery. , 2009, Journal of biochemistry.
[259] S. Muyldermans,et al. Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom. , 2009, The Biochemical journal.
[260] S. Tzipori,et al. Efficient Serum Clearance of Botulinum Neurotoxin Achieved Using a Pool of Small Antitoxin Binding Agents , 2009, Infection and Immunity.
[261] Hisataka Kobayashi,et al. Clinical implications of near-infrared fluorescence imaging in cancer. , 2009, Future oncology.
[262] H. Revets,et al. The development of nanobodies for therapeutic applications. , 2009, Current opinion in investigational drugs.
[263] C. Dobson,et al. 1H, 13C and 15N assignments of a camelid nanobody directed against human α-synuclein , 2009, Biomolecular NMR assignments.
[264] A. Kossiakoff,et al. An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells , 2009, Proceedings of the National Academy of Sciences.
[265] R. Scott,et al. Head‐to‐tail fusions of camelid antibodies can be expressed in planta and bind in rumen fluid , 2009, Biotechnology and applied biochemistry.
[266] C. Verrips,et al. Prevention of oculopharyngeal muscular dystrophy by muscular expression of Llama single-chain intrabodies in vivo. , 2009, Human molecular genetics.
[267] G. Adams,et al. Affinity and avidity in antibody-based tumor targeting. , 2009, Cancer biotherapy & radiopharmaceuticals.
[268] S. Muyldermans,et al. Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis. , 2009, International journal for parasitology.
[269] L. Wyns,et al. Camelid immunoglobulins and nanobody technology. , 2009, Veterinary immunology and immunopathology.
[270] C. Duyckaerts,et al. Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation. , 2009, Molecular immunology.
[271] S. Muyldermans,et al. General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold* , 2009, Journal of Biological Chemistry.
[272] J. Tanha,et al. Isolation of monoclonal antibody fragments from phage display libraries. , 2009, Methods in molecular biology.
[273] P. Choyke,et al. Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. , 2008, Nanomedicine.
[274] S. Muyldermans,et al. VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'. , 2008, Molecular immunology.
[275] C. R. Leemans,et al. Improved tumor targeting of anti–epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology , 2008, Molecular Cancer Therapeutics.
[276] Christian Vanhove,et al. Comparison of the Biodistribution and Tumor Targeting of Two 99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT , 2008, Journal of Nuclear Medicine.
[277] Charles N. Serhan,et al. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators , 2008, Nature Reviews Immunology.
[278] S. Rosenberg,et al. Adoptive cell transfer: a clinical path to effective cancer immunotherapy , 2008, Nature Reviews Cancer.
[279] C. Vanhove,et al. SPECT Imaging with 99mTc-Labeled EGFR-Specific Nanobody for In Vivo Monitoring of EGFR Expression , 2008, Molecular Imaging and Biology.
[280] Frode Willoch,et al. Imaging of opioid receptors in the central nervous system , 2007, Brain : a journal of neurology.
[281] C. Sautès-Fridman,et al. Isolation and characterization of anti-FcgammaRIII (CD16) llama single-domain antibodies that activate natural killer cells. , 2008, Protein engineering, design & selection : PEDS.
[282] Michael J. Osborn,et al. Heavy chain–only antibodies are spontaneously produced in light chain–deficient mice , 2007, The Journal of experimental medicine.
[283] C. Sautès-Fridman,et al. Isolation and characterization of anti-FcgammaRIII (CD16) llama single-domain antibodies that activate natural killer cells. , 2007, Protein engineering, design & selection : PEDS.
[284] C. Sachse,et al. Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils , 2007, Proceedings of the National Academy of Sciences.
[285] Shohei Koide,et al. Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. , 2007, Journal of molecular biology.
[286] Hidde L Ploegh,et al. Sortagging: a versatile method for protein labeling. , 2007, Nature chemical biology.
[287] F. Aires da Silva,et al. Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV1 virion infectivity factor. , 2007, Biosensors & bioelectronics.
[288] J. Stam,et al. Improved anti-IgG and HSA affinity ligands: clinical application of VHH antibody technology. , 2007, Journal of immunological methods.
[289] K. Shannon,et al. Huntington's Disease: Pathological Mechanisms and Therapeutic Strategies , 2007, Cell transplantation.
[290] Yasuyoshi Watanabe,et al. [Molecular imaging for drug development]. , 2007, Brain and nerve = Shinkei kenkyu no shinpo.
[291] A. Verkleij,et al. Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies , 2007, Cancer Immunology, Immunotherapy.
[292] James B Delehanty,et al. Facile generation of heat-stable antiviral and antitoxin single domain antibodies from a semisynthetic llama library. , 2006, Analytical chemistry.
[293] Yaofeng Zhao,et al. Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea. , 2006, The Journal of infectious diseases.
[294] J. Tanha,et al. Identification of single‐domain, Bax‐specific intrabodies that confer resistance to mammalian cells against oxidative‐stress‐induced apoptosis , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[295] Heinrich Leonhardt,et al. Targeting and tracing antigens in live cells with fluorescent nanobodies , 2006, Nature Methods.
[296] F. Grosveld,et al. Generation of heavy-chain-only antibodies in mice , 2006, Proceedings of the National Academy of Sciences.
[297] J. Tommassen,et al. Llama Single-Chain Antibody That Blocks Lipopolysaccharide Binding and Signaling: Prospects for Therapeutic Applications , 2006, Clinical and Vaccine Immunology.
[298] P. Hudson,et al. Latest technologies for the enhancement of antibody affinity. , 2006, Advanced drug delivery reviews.
[299] E. Remaut,et al. Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis. , 2006, Arthritis and rheumatism.
[300] Fred C Tenover,et al. Mechanisms of antimicrobial resistance in bacteria. , 2006, The American journal of medicine.
[301] Lennart Hammarstrom,et al. Reduction in morbidity of rotavirus induced diarrhoea in mice by yeast produced monovalent llama-derived antibody fragments. , 2006, Vaccine.
[302] L. Hammarström,et al. Therapeutic effect of llama derived VHH fragments against Streptococcus mutans on the development of dental caries , 2006, Applied Microbiology and Biotechnology.
[303] S. Muyldermans,et al. Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor , 2006, Nature Medicine.
[304] L. Wyns,et al. Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[305] M. Stocks. Intracellular antibodies: a revolution waiting to happen? , 2006, Current opinion in molecular therapeutics.
[306] T. Niewold,et al. Selection and optimization of proteolytically stable llama single-domain antibody fragments for oral immunotherapy , 2006, Applied Microbiology and Biotechnology.
[307] Michael J. Osborn,et al. Heavy-chain-only antibody expression and B-cell development in the mouse. , 2006, Critical reviews in immunology.
[308] N. Matsuda,et al. Systemic inflammatory response syndrome (SIRS): molecular pathophysiology and gene therapy. , 2006, Journal of Pharmacological Sciences.
[309] G. van Ommen,et al. Prevention of oculopharyngeal muscular dystrophy-associated aggregation of nuclear polyA-binding protein with a single-domain intracellular antibody. , 2006, Human molecular genetics.
[310] F. V. van Zijderveld,et al. Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea. , 2005, Veterinary microbiology.
[311] L. Hammarström,et al. Passive immunization by lactobacilli expressing single-chain antibodies against Streptococcus mutans , 2005, Molecular biotechnology.
[312] H. Sprong,et al. The blood–brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells , 2005, Journal of neurochemistry.
[313] M. Harmsen,et al. Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins. , 2005, Vaccine.
[314] Jennifer A. Smith,et al. Supplementary Material References Subscriptions Permissions Email Alerts Expression of a Dromedary Heavy Chain-Only Antibody and B Cell Development in the Mouse , 2013 .
[315] A. Messer,et al. Intrabody applications in neurological disorders: progress and future prospects. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[316] G. Vriend,et al. Isolation of Llama Antibody Fragments for Prevention of Dandruff by Phage Display in Shampoo , 2005, Applied and Environmental Microbiology.
[317] L. Trudel,et al. Monoclonal versus polyclonal antibodies: distinguishing characteristics, applications, and information resources. , 2005, ILAR journal.
[318] P. Weissberg,et al. Molecular and metabolic imaging of atherosclerosis. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[319] J. W. Bos,et al. Bactericidal Effects of a Fusion Protein of Llama Heavy-Chain Antibodies Coupled to Glucose Oxidase on Oral Bacteria , 2004, Antimicrobial Agents and Chemotherapy.
[320] J. Kelly,et al. A pentavalent single-domain antibody approach to tumor antigen discovery and the development of novel proteomics reagents. , 2004, Journal of molecular biology.
[321] M. Papamichail,et al. Targeting of tumor cells by lymphocytes engineered to express chimeric receptor genes , 2004, Cancer Immunology, Immunotherapy.
[322] Serge Muyldermans,et al. Efficient cancer therapy with a nanobody-based conjugate. , 2004, Cancer research.
[323] W. Tatton,et al. Interrupting apoptosis in neurodegenerative disease: potential for effective therapy? , 2004, Drug discovery today.
[324] L. Wyns,et al. Efficient Targeting of Conserved Cryptic Epitopes of Infectious Agents by Single Domain Antibodies , 2004, Journal of Biological Chemistry.
[325] H. Karoui,et al. Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins. , 2003, Toxicon : official journal of the International Society on Toxinology.
[326] W. Birchmeier,et al. Met, metastasis, motility and more , 2003, Nature Reviews Molecular Cell Biology.
[327] W. Gibson. Faculty Opinions recommendation of Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm. , 2003 .
[328] Shenghua Li,et al. Selection of hapten-specific single-domain antibodies from a non-immunized llama ribosome display library. , 2003, Journal of immunological methods.
[329] B. Aggarwal. Signalling pathways of the TNF superfamily: a double-edged sword , 2003, Nature Reviews Immunology.
[330] T. Rabbitts,et al. Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies. , 2003, Journal of molecular biology.
[331] K Kümmerer,et al. Significance of antibiotics in the environment. , 2003, The Journal of antimicrobial chemotherapy.
[332] T. Wilkins,et al. Infection in Mice , 2003 .
[333] L. Wyns,et al. Single‐domain antibody fragments with high conformational stability , 2002, Protein science : a publication of the Protein Society.
[334] J. Tanha,et al. Selection of phage‐displayed llama single‐domain antibodies that transmigrate across human blood‐brain barrier endothelium , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[335] J. Frère,et al. β-Lactamase Inhibitors Derived from Single-Domain Antibody Fragments Elicited in the Camelidae , 2001, Antimicrobial Agents and Chemotherapy.
[336] C Cambillau,et al. Thermal unfolding of a llama antibody fragment: a two-state reversible process. , 2001, Biochemistry.
[337] E. Simões. Respiratory syncytial virus infection , 1999, The Lancet.
[338] H. Warner. Apoptosis: A Two‐edged Sword in Aging , 1999, Annals of the New York Academy of Sciences.
[339] K. Frei,et al. Severity of symptoms and demyelination in MOG‐induced EAE depends on TNFR1 , 1999, European journal of immunology.
[340] L. Wyns,et al. Camel single‐domain antibody inhibits enzyme by mimicking carbohydrate substrate , 1998, Proteins.
[341] Lode Wyns,et al. Potent enzyme inhibitors derived from dromedary heavy‐chain antibodies , 1998, The EMBO journal.
[342] L. Wyns,et al. Selection and identification of single domain antibody fragments from camel heavy‐chain antibodies , 1997, FEBS letters.
[343] I. Bahar,et al. [Epidermal growth factor receptor]. , 1994, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
[344] S. Muyldermans,et al. Naturally occurring antibodies devoid of light chains , 1993, Nature.
[345] J. Carlson,et al. A new means of inducibly inactivating a cellular protein , 1988, Molecular and cellular biology.
[346] C. Werning. [Rheumatoid arthritis]. , 1983, Medizinische Monatsschrift fur Pharmazeuten.