The Pamir forms the northwestern tail of the Tibetan plateau and is a first-order tectonic feature of the Cenozoic Indo-Eurasian collision. The nature of the topographic uplift and orogenic growth of the entire northwestern margin of the Pamir is poorly constrained; however, this history can provide important constraints that are required to test geodynamic models of the tectonic evolution of the Pamir. Here we focus on the uplift history of the western and northwestern unglaciated margin of the Northern Pamir, the Darvaz and the Peter-the-First Ranges. These three ranges were formed by three major fault systems: the Main Pamir Thrust (MPT), the Darvaz and the Vakhsh fault zones (DFZ, VFZ). To assess the impact of tectonic uplift on the geomorphic evolution, we analyzed geomorphic characteristics of the topography, the longitudinal river profiles and the relief. To better constrain the regional crustal cooling history and uplift, we obtained thermochronologic cooling ages from the three regions.