Directory of registries of clinical trials.

Registries of clinical trials are a potentially useful resource for the planning of new studies, the promotion of communication and collaboration between researchers, the conduct of meta-analyses, and the facilitation of patient access and recruitment to trials. However, many physicians and researchers are unaware of their existence, and as a result they remain underused. A directory of registries of clinical trials has been developed as a result of an international survey of 63 organizations and 51 individuals in 13 different countries to identify the existence of such registries. This is intended as a resource to keep physicians, researchers, trial organizers, funding bodies and government agencies abreast of the growing number of registries available, and to assist in the planning of future registries. Twenty-four current and six planned registries of clinical trials have been identified. Most focus on AIDS or oncology, but such diverse areas as neurosurgery, cardiovascular disease, dentistry and perinatology are also represented. This paper presents a descriptive profile on each registry and discusses the relative merits of their different organizational features. Recommendations are given for the establishment of future registries.

[1]  T C Chalmers,et al.  The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials. , 1978, The New England journal of medicine.

[2]  J. Reed,et al.  Statistical proof in inconclusive 'negative' trials. , 1981, Archives of internal medicine.

[3]  Minoru Kanehisa,et al.  The GenBank nucleic acid sequence database , 1985, Comput. Appl. Biosci..

[4]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[5]  R. Simes Publication bias: the case for an international registry of clinical trials. , 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  T. Chalmers,et al.  Meta-analyses of randomized controlled trials. , 1987, The New England journal of medicine.

[7]  R. Sher,et al.  Seroepidemiology of human immunodeficiency virus in Africa from 1970 to 1974. , 1987, The New England journal of medicine.

[8]  P Easterbrook,et al.  Psychological problems associated with lymphomas , 1987, British medical journal.

[9]  K. Dickersin Reference bias in reports of drug trials. , 1987, British medical journal.

[10]  R G Newcombe,et al.  Towards a reduction in publication bias. , 1987, British medical journal.

[11]  R. Wittes,et al.  Accrual to Clinical Trials1 , 1988 .

[12]  C. Meinert,et al.  Toward prospective registration of clinical trials. , 1988, IRB.

[13]  J. Samet,et al.  Cancer treatment protocols. Who gets chosen? , 1988, Archives of internal medicine.

[14]  K. Dickersin,et al.  Report from the panel on the Case for Registers of Clinical Trials at the Eighth Annual Meeting of the Society for Clinical Trials. , 1988, Controlled clinical trials.

[15]  F. Bernstein The retrieval of randomized clinical trials in liver diseases from the medical literature: manual versus MEDLARS searches. , 1988, Controlled clinical trials.

[16]  H. Mouridsen,et al.  Danish Breast Cancer Cooperative Group (DBCG). A description of the register of the nation-wide programme for primary breast cancer. , 1988, Acta oncologica.

[17]  J. Bogousslavsky,et al.  The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke. , 1988, Stroke.

[18]  I. Chalmers,et al.  Retrospective and prospective identification of unpublished controlled trials: lessons from a survey of obstetricians and pediatricians. , 1989, Pediatrics.