Workflow for managing impurities in an integrated crystallization process

A workflow consisting of experiments, modeling, and synthesis is presented for managing the impurity content in the product crystals of a crystallization process taking into consideration the entire train of crystallization and downstream processing steps. Experiments on solid–liquid equilibrium, impurity inclusion, washing, and deliquoring are designed in such a way that the experimental data or the model parameters derived from these data can be readily used for process design. Guidelines for experimental design and tradeoffs in process synthesis are discussed. The workflow is illustrated using the purification of Vitamin C (ascorbic acid) as a case study. © 2009 American Institute of Chemical Engineers AIChE J, 2010

[1]  Christianto Wibowo,et al.  Synthesis of crystallization processes for systems involving solid solutions , 2008, Comput. Chem. Eng..

[2]  Modelling of Alditol Impurity Incorporation into Galactitol Crystals , 2006 .

[3]  Christianto Wibowo,et al.  Beyond process design: The emergence of a process development focus , 2003 .

[4]  Christianto Wibowo,et al.  Producing Nanoparticles Using Precipitation with Compressed Antisolvent , 2007 .

[5]  Ka Ming Ng,et al.  Synthesis of processing system around a crystallizer , 1998 .

[6]  Angelo Chianese,et al.  Determination of Critical Seed Loading Ratio for the Production of Crystals of Uni-Modal Size Distribution in Batch Cooling Crystallization of Potassium Alum , 2002 .

[7]  A. Myerson,et al.  Development of a Small-Scale Automated Solubility Measurement Apparatus , 2005 .

[8]  Chiehming J. Chang,et al.  Phase equilibrium of ethanol + CO{sub 2} and acetone + CO{sub 2} at elevated pressures , 1996 .

[9]  E. T. White,et al.  Studies on liquid inclusions in crystals , 1966 .

[10]  Christianto Wibowo,et al.  Visualization of high‐dimensional phase diagrams of molecular and ionic mixtures , 2002 .

[11]  F. Puel,et al.  Real-time evaluation of the concentration of impurities during organic solution crystallization , 2003 .

[12]  Christianto Wibowo,et al.  Design of integrated crystallization systems , 2001 .

[13]  San Kiang,et al.  One-dimensional centrifugation model , 2003 .

[14]  David J.W. Grant,et al.  Formation of Liquid Inclusions in Adipic Acid Crystals during Recrystallization from Aqueous Solutions , 2005 .

[15]  K. Ng,et al.  Diastereomeric salt crystallization synthesis for chiral resolution of ibuprofen , 2007 .

[16]  Christianto Wibowo,et al.  Integrative Approach for Polymorphic Crystallization Process Synthesis , 2007 .

[17]  H. C. Chan,et al.  Experimental Determination of Solid−Liquid Equilibrium Phase Diagrams for Crystallization-Based Process Synthesis , 2005 .

[18]  Ka Ming Ng,et al.  MOPSD: a framework linking business decision-making to product and process design , 2004, Comput. Chem. Eng..