Microbiota, Oral Microbiome, and Pancreatic Cancer

AbstractOnly 30% of patients with a diagnosis of pancreatic cancer survive 1 year after the diagnosis. Progress in understanding the causes of pancreatic cancer has been made, including solidifying the associations with obesity and diabetes, and a proportion of cases should be preventable through lifestyle modifications. Unfortunately, identifying reliable biomarkers of early pancreatic cancer has been extremely challenging, and no effective screening modality is currently available for this devastating form of cancer. Recent data suggest that the microbiota may play a role in the disease process, but many questions remain. Future studies focusing on the human microbiome, both etiologically and as a marker of disease susceptibility, should shed light on how to better tackle prevention, early detection, and treatment of this highly fatal disease.

[1]  D. Seehofer,et al.  Bacterial biofilm within diseased pancreatic and biliary tracts , 2005, Gut.

[2]  A. Jemal,et al.  Cancer statistics, 2014 , 2014, CA: a cancer journal for clinicians.

[3]  J. Barkin,et al.  The role of percutaneous aspiration in the diagnosis of pancreatic abscess. , 1983, AJR. American journal of roentgenology.

[4]  R. Garcia,et al.  Validity of a self-reported periodontal disease measure. , 1996, Journal of public health dentistry.

[5]  Atsuo Ochi,et al.  MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells , 2012, The Journal of experimental medicine.

[6]  Michelle A. Anderson,et al.  A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development , 2008, PLoS medicine.

[7]  N. Salama,et al.  Helicobacter pylori's Unconventional Role in Health and Disease , 2009, PLoS pathogens.

[8]  J. Izard,et al.  The Human Oral Microbiome , 2010, Journal of bacteriology.

[9]  P. Ray,et al.  Bacteriology of infection in severe acute pancreatitis. , 2011, JOP : Journal of the pancreas.

[10]  M. Laine,et al.  The Capsule of Porphyromonas gingivalis Leads to a Reduction in the Host Inflammatory Response, Evasion of Phagocytosis, and Increase in Virulence , 2011, Infection and Immunity.

[11]  D. Roe,et al.  Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans. , 1991, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[12]  E. Rimm,et al.  Periodontal Disease and Biomarkers Related to Cardiovascular Disease , 2004, Journal of dental research.

[13]  J. Kerr,et al.  Genetic diversity in the oral pathogen Porphyromonas gingivalis: molecular mechanisms and biological consequences. , 2013, Future microbiology.

[14]  D. Spiegelman,et al.  History of peptic ulcer disease and pancreatic cancer risk in men. , 2010, Gastroenterology.

[15]  P. Ridker,et al.  Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women , 2008, PLoS genetics.

[16]  F. C. Gibson,et al.  Protective Role for TLR4 Signaling in Atherosclerosis Progression as Revealed by Infection with a Common Oral Pathogen , 2012, The Journal of Immunology.

[17]  Yuan Tian,et al.  Expression and significance of TLR4 and HIF-1alpha in pancreatic ductal adenocarcinoma. , 2010, World journal of gastroenterology.

[18]  M. Nowak,et al.  Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer , 2010, Nature.

[19]  A. Widdison.  Pathogenesis of pancreatic infection. , 1996, Annals of the Royal College of Surgeons of England.

[20]  F. C. Gibson,et al.  Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. , 2010, Molecular oral microbiology.

[21]  P. Papapanou,et al.  Periodontal diseases: epidemiology. , 1996, Annals of periodontology.

[22]  P. Malfertheiner,et al.  The role of infection in acute pancreatitis , 1999, Gut.

[23]  N. Weiss,et al.  An exploration of the periodontitis-cancer association. , 2003, Annals of epidemiology.

[24]  B. Lindkvist,et al.  A prospective study of Helicobacter pylori in relation to the risk for pancreatic cancer , 2008, BMC Cancer.

[25]  S. Socransky,et al.  Evidence of bacterial etiology: a historical perspective. , 1994, Periodontology 2000.

[26]  S. Hanash,et al.  A Compendium of Potential Biomarkers of Pancreatic Cancer , 2009, PLoS medicine.

[27]  H. Reber,et al.  Routes of spread of pathogens into the pancreas in a feline model of acute pancreatitis. , 1994, Gut.

[28]  Haitao Wen,et al.  Porphyromonas gingivalis Mediates Inflammasome Repression in Polymicrobial Cultures through a Novel Mechanism Involving Reduced Endocytosis* , 2012, The Journal of Biological Chemistry.

[29]  M. Büchler,et al.  Bacterial translocation and infected pancreatic necrosis in acute necrotizing pancreatitis derives from small bowel rather than from colon. , 2010, American journal of surgery.

[30]  M. L. Hartung,et al.  Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori , 2013, Nature Reviews Microbiology.

[31]  R. Hayes,et al.  Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. , 2012, Carcinogenesis.

[32]  D. Kinane,et al.  Bacteraemia following periodontal procedures , 2005, Journal of clinical periodontology.

[33]  D. Albanes,et al.  Seropositivity to Helicobacter pylori and Risk of Pancreatic Cancer , 2013, Cancer Epidemiology, Biomarkers & Prevention.

[34]  M. Asaka,et al.  Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial , 2008, The Lancet.

[35]  C. de Martel,et al.  Helicobacter pylori Infection and Development of Pancreatic Cancer , 2008, Cancer Epidemiology Biomarkers & Prevention.

[36]  E. Giovannucci,et al.  A prospective study of periodontal disease and pancreatic cancer in US male health professionals. , 2006, Journal of the National Cancer Institute.

[37]  Fenghua Wang,et al.  ABO blood group, hepatitis B viral infection and risk of pancreatic cancer , 2012, International journal of cancer.

[38]  Matthew Turk,et al.  Risks , 2016, Computing in Science & Engineering.

[39]  M. Blaser,et al.  Helicobacter pylori seropositivity as a risk factor for pancreatic cancer. , 2001, Journal of the National Cancer Institute.

[40]  E. Giovannucci,et al.  A review of the relationship between tooth loss, periodontal disease, and cancer , 2008, Cancer Causes & Control.

[41]  Yinfeng Shen,et al.  Microbiological Findings in Secondary Infection of Severe Acute Pancreatitis: A Retrospective Clinical Study , 2009, Pancreas.

[42]  Mark A Reynolds,et al.  State of the science: chronic periodontitis and systemic health. , 2012, The journal of evidence-based dental practice.

[43]  D. Chia,et al.  Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer , 2011, Gut.

[44]  H. Bartsch,et al.  Endogenous formation of nitrosamines and oxidative DNA-damaging agents in tobacco users. , 1996, Critical reviews in toxicology.

[45]  T. Bengtsson,et al.  Porphyromonas gingivalis downregulates the immune response of fibroblasts , 2013, BMC Microbiology.

[46]  J. Sconyers,et al.  Relationship of bacteremia to toothbrushing in patients with periodontitis. , 1973, Journal of the American Dental Association.

[47]  Geoffrey S. Tobias,et al.  Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer , 2009, Nature Genetics.

[48]  E. Fontham,et al.  Helicobacter pylori and gastric carcinoma: Serum antibody prevalence in populations with contrasting cancer risks , 1990, Cancer.

[49]  P. Steiner.  Human carcinogens. , 1947, Annals of western medicine and surgery.

[50]  F. Clavel-Chapelon,et al.  Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study , 2012, Gut.

[51]  W. Scheithauer,et al.  Association between Helicobacter pylori Infection and Pancreatic Cancer , 1997, Oncology.

[52]  D. Whitcomb,et al.  Inflammation and pancreatic cancer: an evidence-based review. , 2009, Current opinion in pharmacology.

[53]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.

[54]  M. Blaser,et al.  Helicobacter pylori Seropositivity as a Risk Factor for Pancreatic Cancer , 2001 .

[55]  T. Hamasaki,et al.  Association between tooth loss and orodigestive cancer mortality in an 80-year-old community-dwelling Japanese population: a 12-year prospective study , 2013, BMC Public Health.

[56]  Peng Wei,et al.  Insights into Pancreatic Cancer Etiology from Pathway Analysis of Genome-Wide Association Study Data , 2012, PloS one.

[57]  M. Blanca Piazuelo,et al.  Gastric cáncer: Overview , 2013, Colombia medica.

[58]  K. Ryu,et al.  Randomised clinical trial: the effects of Helicobacter pylori eradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer , 2013, Alimentary pharmacology & therapeutics.

[59]  H. Risch,et al.  Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. , 2004, Journal of the National Cancer Institute.

[60]  I. Brook,et al.  Microbiological analysis of pancreatic abscess. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[61]  H. Risch,et al.  ABO blood group, Helicobacter pylori seropositivity, and risk of pancreatic cancer: a case-control study. , 2010, Journal of the National Cancer Institute.