Measuring the impact of laboratory medicine on clinical management and patient outcomes

Corresponding author: Prof. Mario Plebani Department of Laboratory Medicine University-Hospital of Padova 35128 Padova, Italy Phone: +390498212792 Fax: +39049663240 E-mail: mario.plebani@unipd.it

[1]  F. Hutchinson Characterizing Expected Benefits of Biomarkers in Treatment Selection , 2017 .

[2]  Andrew Georgiou,et al.  Releasing test results directly to patients: A multisite survey of physician perspectives. , 2015, Patient education and counseling.

[3]  Robert H Brook,et al.  Emergency physician perceptions of medically unnecessary advanced diagnostic imaging. , 2015, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[4]  J. Westbrook,et al.  Maternity Patients' Access to Their Electronic Medical Records: Use and Perspectives of a Patient Portal , 2015, Health information management : journal of the Health Information Management Association of Australia.

[5]  P. Bossuyt,et al.  Evaluating Biomarkers for Guiding Treatment Decisions , 2015, EJIFCC.

[6]  R. Batrla,et al.  The Clinical and Health Economic Value of Clinical Laboratory Diagnostics , 2015, EJIFCC.

[7]  M. Cowie National Institute for Health and Care Excellence. , 2015, European heart journal.

[8]  M. Porath,et al.  Using vaginal Group B Streptococcus colonisation in women with preterm premature rupture of membranes to guide the decision for immediate delivery: a secondary analysis of the PPROMEXIL trials , 2014, BJOG : an international journal of obstetrics and gynaecology.

[9]  J. Trojanowski,et al.  INCLUSION OF PATIENTS WITH ALZHEIMER'S DISEASE PATHOLOGY IN SOLANEZUMAB EXPEDITION 3 USING FLORBETAPIR PET IMAGING OR INNO-BIA ALZBIO3 CSF Aβ1-42 , 2014, Alzheimer's & Dementia.

[10]  Hardeep Singh,et al.  Patient access to medical records and healthcare outcomes: a systematic review , 2014, J. Am. Medical Informatics Assoc..

[11]  Nick C Fox,et al.  Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria , 2014, The Lancet Neurology.

[12]  A. Horvath,et al.  Harmonization of critical result management in laboratory medicine. , 2014, Clinica chimica acta; international journal of clinical chemistry.

[13]  Jennifer H Barnett,et al.  Early intervention in Alzheimer’s disease: a health economic study of the effects of diagnostic timing , 2014, BMC Neurology.

[14]  J. Coresh,et al.  GFR estimation: from physiology to public health. , 2014, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[15]  Holly Janes,et al.  An Approach to Evaluating and Comparing Biomarkers for Patient Treatment Selection , 2014, The international journal of biostatistics.

[16]  E. Sadroddiny,et al.  Biomolecular markers in assessment and treatment of asthma , 2014, Respirology.

[17]  Douglas G. Altman,et al.  Methods for Specifying the Target Difference in a Randomised Controlled Trial: The Difference ELicitation in TriAls (DELTA) Systematic Review , 2014, PLoS medicine.

[18]  Andrew Georgiou,et al.  Lessons learned from the introduction of an electronic safety net to enhance test result management in an Australian mothers’ hospital , 2014, J. Am. Medical Informatics Assoc..

[19]  Brian R. Jackson,et al.  Primary Care Physicians' Challenges in Ordering Clinical Laboratory Tests and Interpreting Results , 2014, The Journal of the American Board of Family Medicine.

[20]  E. Siemers,et al.  Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. , 2014, The New England journal of medicine.

[21]  N. Hanania,et al.  Periostin, a novel biomarker of TH2-driven asthma , 2014, Current opinion in pulmonary medicine.

[22]  Sverre Sandberg,et al.  From biomarkers to medical tests: the changing landscape of test evaluation. , 2014, Clinica chimica acta; international journal of clinical chemistry.

[23]  E. Bleecker,et al.  International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma , 2013, European Respiratory Journal.

[24]  Neil M. Paige,et al.  Electronic Patient Portals: Evidence on Health Outcomes, Satisfaction, Efficiency, and Attitudes , 2013, Annals of Internal Medicine.

[25]  Ramin Khorasani,et al.  An initiative to improve the management of clinically significant test results in a large health care network. , 2013, Joint Commission journal on quality and patient safety.

[26]  Bart Hilvering,et al.  Clinical utility of asthma biomarkers: from bench to bedside , 2013, Biologics : targets & therapy.

[27]  J. Januzzi Natriuretic Peptides as Biomarkers in Heart Failure , 2013, Journal of Investigative Medicine.

[28]  Andrew Georgiou,et al.  The effect of computerized provider order entry systems on clinical care and work processes in emergency departments: a systematic review of the quantitative literature. , 2013, Annals of emergency medicine.

[29]  Mario Plebani,et al.  Harmonization in laboratory medicine: the complete picture , 2013, Clinical chemistry and laboratory medicine.

[30]  Michael W. Smith,et al.  Primary care practitioners’ views on test result management in EHR-enabled health systems: a national survey , 2012, J. Am. Medical Informatics Assoc..

[31]  Graham H. Beastall,et al.  Adding value to laboratory medicine: a professional responsibility , 2012, Clinical chemistry and laboratory medicine.

[32]  Mario Plebani,et al.  The CCLM contribution to improvements in quality and patient safety , 2012, Clinical chemistry and laboratory medicine.

[33]  D. Coyle,et al.  COST-UTILITY ANALYSIS OF NT-PROBNP-GUIDED MULTIDISCIPLINARY CARE IN CHRONIC HEART FAILURE , 2012, International Journal of Technology Assessment in Health Care.

[34]  E. R. Sutherland,et al.  A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. , 2012, American journal of respiratory and critical care medicine.

[35]  Elske Ammenwerth,et al.  The Impact of Electronic Patient Portals on Patient Care: A Systematic Review of Controlled Trials , 2012, Journal of medical Internet research.

[36]  C. Campbell,et al.  Towards harmonisation of critical laboratory result management - review of the literature and survey of australasian practices. , 2012, The Clinical biochemist. Reviews.

[37]  Keith A. Johnson,et al.  Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline , 2012, Neurology.

[38]  Joann G Elmore,et al.  Inviting Patients to Read Their Doctors' Notes: A Quasi-experimental Study and a Look Ahead , 2011, Annals of Internal Medicine.

[39]  B. Mol,et al.  Management of late-preterm premature rupture of membranes: the PPROMEXIL-2 trial. , 2012, American journal of obstetrics and gynecology.

[40]  Farah Magrabi,et al.  Last Orders: Follow-up of Tests Ordered on the Day of Hospital Discharge. , 2012, Archives of internal medicine.

[41]  P. Nair,et al.  Serum periostin as a marker of T(H)2-dependent eosinophilic airway inflammation. , 2012, The Journal of allergy and clinical immunology.

[42]  S. Mosesova,et al.  Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. , 2011, The Journal of allergy and clinical immunology.

[43]  P. Scheltens,et al.  Diagnostic and economic evaluation of new biomarkers for Alzheimer’s disease: the research protocol of a prospective cohort study , 2012, BMC Neurology.

[44]  Tim Usherwood,et al.  Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: new developments and revised recommendations , 2012, The Medical journal of Australia.

[45]  Mario Plebani,et al.  Quality indicators to detect pre-analytical errors in laboratory testing. , 2012, The Clinical biochemist. Reviews.

[46]  Stephen Colagiuri,et al.  Chronic kidney disease and measurement of albuminuria or proteinuria: a position statement , 2012, The Medical journal of Australia.

[47]  S. Silverman,et al.  National Bone Health Alliance Bone Turnover Marker Project: current practices and the need for US harmonization, standardization, and common reference ranges , 2012, Osteoporosis International.

[48]  Dean F. Sittig,et al.  Improving Test Result Follow-up through Electronic Health Records Requires More than Just an Alert , 2012, Journal of General Internal Medicine.

[49]  Robert A Silverman,et al.  Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma. , 2012, The Journal of allergy and clinical immunology.

[50]  C. B. Alexander,et al.  Message from the President: Reducing Healthcare Costs through Appropriate Test Utilization , 2012 .

[51]  B. Mol,et al.  Induction of Labor versus Expectant Management in Women with Preterm Prelabor Rupture of Membranes between 34 and 37 Weeks: A Randomized Controlled Trial , 2012, PLoS Medicine.

[52]  J. Möcks,et al.  N‐terminal pro brain natriuretic peptide in the management of patients in the medical emergency department (PROMPT): correlation with disease severity, utilization of hospital resources, and prognosis in a large, prospective, randomized multicentre trial , 2012, European journal of heart failure.

[53]  Mario Plebani,et al.  Exploring the initial steps of the testing process: frequency and nature of pre-preanalytic errors. , 2012, Clinical chemistry.

[54]  D. Taylor Biomarkers of Inflammation in Asthma: A Clinical Perspective , 2012, Seminars in Respiratory and Critical Care Medicine.

[55]  Thomas W Feeley,et al.  Access to the Medical Record for Patients and Involved Providers: Transparency Through Electronic Tools , 2011, Annals of Internal Medicine.

[56]  Andrew Georgiou,et al.  Failure to Follow-Up Test Results for Ambulatory Patients: A Systematic Review , 2011, Journal of General Internal Medicine.

[57]  Hardeep Singh,et al.  Should patients get direct access to their laboratory test results? An answer with many questions. , 2011, JAMA.

[58]  Luca Pani,et al.  Qualification opinion of novel methodologies in the predementia stage of Alzheimer's disease: Cerebro-spinal-fluid related biomarkers for drugs affecting amyloid burden — Regulatory considerations by European Medicines Agency focusing in improving benefit/risk in regulatory trials , 2011, European Neuropsychopharmacology.

[59]  Nicola A Hanania,et al.  Lebrikizumab treatment in adults with asthma. , 2011, The New England journal of medicine.

[60]  D McDaid,et al.  The economic impact of dementia in Europe in 2008—cost estimates from the Eurocode project , 2011, International journal of geriatric psychiatry.

[61]  M. Stockler,et al.  Lung cancer clinicians' preferences for adjuvant chemotherapy in non-small-cell lung cancer: what makes it worthwhile? , 2011, Lung cancer.

[62]  Nick C Fox,et al.  The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[63]  J. Morris,et al.  The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[64]  Denise C. Park,et al.  Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[65]  A. Khera,et al.  Forecasting the Future of Cardiovascular Disease in the United States: A Policy Statement From the American Heart Association , 2011, Circulation.

[66]  Holly Janes,et al.  Measuring the Performance of Markers for Guiding Treatment Decisions , 2011, Annals of Internal Medicine.

[67]  Andrew Georgiou,et al.  The safety implications of missed test results for hospitalised patients: a systematic review , 2011, Quality and Safety in Health Care.

[68]  D. Greenfield,et al.  Applying and developing health service theory: an empirical study into clinical governance , 2011 .

[69]  Christian Humpel,et al.  Identifying and validating biomarkers for Alzheimer's disease , 2011, Trends in biotechnology.

[70]  Anuj K. Dalal,et al.  Lessons learned from implementation of a computerized application for pending tests at hospital discharge. , 2011, Journal of hospital medicine.

[71]  C. Cooper,et al.  Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards , 2011, Osteoporosis International.

[72]  Hilary K. Wall,et al.  Costs of heart failure-related hospitalizations in patients aged 18 to 64 years. , 2010, The American journal of managed care.

[73]  R. V. Van Heertum,et al.  Pittsburgh Compound B (11C-PIB) and Fluorodeoxyglucose (18 F-FDG) PET in Patients With Alzheimer Disease, Mild Cognitive Impairment, and Healthy Controls , 2010, Journal of geriatric psychiatry and neurology.

[74]  M. Stockler,et al.  Adjuvant chemotherapy for early colon cancer: what survival benefits make it worthwhile? , 2010, European journal of cancer.

[75]  Dean F. Sittig,et al.  Ten Strategies to Improve Management of Abnormal Test Result Alerts in the Electronic Health Record , 2010, Journal of patient safety.

[76]  W. Busse,et al.  Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. , 2010, American journal of respiratory and critical care medicine.

[77]  John Flach,et al.  The management of test results in primary care: does an electronic medical record make a difference? , 2010, Family medicine.

[78]  David W Bates,et al.  Can electronic clinical documentation help prevent diagnostic errors? , 2010, The New England journal of medicine.

[79]  Mario Plebani,et al.  The detection and prevention of errors in laboratory medicine , 2010, Annals of clinical biochemistry.

[80]  E. Gaygısız,et al.  The Organisation for Economic Co-operation and Development (OECD) , 2022 .

[81]  L. Thurfjell,et al.  Phase 1 Study of the Pittsburgh Compound B Derivative 18F-Flutemetamol in Healthy Volunteers and Patients with Probable Alzheimer Disease , 2009, Journal of Nuclear Medicine.

[82]  Jennie J Gallimore,et al.  Management of Test Results in Family Medicine Offices , 2009, The Annals of Family Medicine.

[83]  Urmimala Sarkar,et al.  Frequency of failure to inform patients of clinically significant outpatient test results. , 2009, Archives of internal medicine.

[84]  Mario Plebani,et al.  Exploring the iceberg of errors in laboratory medicine. , 2009, Clinica chimica acta; international journal of clinical chemistry.

[85]  L. Lynd,et al.  Economic burden of asthma: a systematic review , 2009, BMC pulmonary medicine.

[86]  Pierre Lewalle,et al.  Towards an International Classification for Patient Safety: the conceptual framework , 2009, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[87]  M. Brigden,et al.  Factitious biochemical measurements resulting from hematologic conditions. , 2009, American journal of clinical pathology.

[88]  Maurice O'Kane The reporting, classification and grading of quality failures in the medical laboratory. , 2009, Clinica chimica acta; international journal of clinical chemistry.

[89]  E. Rackow Rehospitalizations among patients in the Medicare fee-for-service program. , 2009, The New England journal of medicine.

[90]  N. Thomson,et al.  Identification and management of adults with asthma prone to exacerbations: can we do better? , 2008, BMC pulmonary medicine.

[91]  M. Guglin,et al.  BNP or NTproBNP? A clinician's perspective. , 2008, International journal of cardiology.

[92]  M. Stockler,et al.  Comparing patients' and their partners' preferences for adjuvant chemotherapy in early breast cancer. , 2008, Patient Education and Counseling.

[93]  Kent B Lewandrowski,et al.  Clinical uncertainty, diagnostic accuracy, and outcomes in emergency department patients presenting with dyspnea. , 2008, Archives of internal medicine.

[94]  J. Sterne,et al.  A review identifies and classifies reasons for ordering diagnostic tests. , 2007, Journal of clinical epidemiology.

[95]  J. Bond,et al.  Evaluating Follow‐Up of Positive Fecal Occult Blood Test Results: Lessons Learned , 2007, Journal for healthcare quality : official publication of the National Association for Healthcare Quality.

[96]  D. Postma,et al.  Severe exacerbations predict excess lung function decline in asthma , 2007, European Respiratory Journal.

[97]  Hardeep Singh,et al.  Research Paper: Communication Outcomes of Critical Imaging Results in a Computerized Notification System , 2007, J. Am. Medical Informatics Assoc..

[98]  Mario Plebani,et al.  Errors in a stat laboratory: types and frequencies 10 years later. , 2007, Clinical chemistry.

[99]  A. Sood,et al.  Non-evidence-based variables affecting physicians' test-ordering tendencies: a systematic review. , 2007, The Netherlands journal of medicine.

[100]  J. Bousquet,et al.  Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach. , 2007 .

[101]  Johanna I. Westbrook,et al.  Research Paper: The Effect of Physicians' Long-term Use of CPOE on Their Test Management Work Practices , 2006, J. Am. Medical Informatics Assoc..

[102]  M. Panteghini,et al.  The importance of metrological traceability on the validity of creatinine measurement as an index of renal function: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) , 2006, Clinical chemistry and laboratory medicine.

[103]  S. Peters,et al.  Uncontrolled asthma: a review of the prevalence, disease burden and options for treatment. , 2006, Respiratory medicine.

[104]  S. Braman The global burden of asthma. , 2006, Chest.

[105]  J. Molina,et al.  An international observational prospective study to determine the cost of asthma exacerbations (COAX). , 2006, Respiratory medicine.

[106]  L. Boulet,et al.  Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations , 2006, European Respiratory Journal.

[107]  Antoni Bayes-Genis,et al.  NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: the International Collaborative of NT-proBNP Study. , 2006, European heart journal.

[108]  Z. Mogyorósy,et al.  [Practice pattern and geographic variation in test ordering. A literature review]. , 2006, Orvosi hetilap.

[109]  P. J. Howanitz,et al.  Errors in laboratory medicine: practical lessons to improve patient safety. , 2009, Archives of pathology & laboratory medicine.

[110]  N. Franklin,et al.  Diagnostic error in internal medicine. , 2005, Archives of internal medicine.

[111]  David M Studdert,et al.  Defensive medicine among high-risk specialist physicians in a volatile malpractice environment. , 2005, JAMA.

[112]  Daniel J Sargent,et al.  Clinical trial designs for predictive marker validation in cancer treatment trials. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[113]  David W Bates,et al.  Communicating critical test results: safe practice recommendations. , 2005, Joint Commission journal on quality and patient safety.

[114]  M. Redaélli,et al.  Asthma: prevalence and cost of illness , 2005, European Respiratory Journal.

[115]  S. Saint,et al.  Fumbled Handoffs: One Dropped Ball after Another Improving Patient Care , 2005 .

[116]  David W Bates,et al.  "I wish I had seen this test result earlier!": Dissatisfaction with test result management systems in primary care. , 2004, Archives of internal medicine.

[117]  J. V. D. van den Ouweland,et al.  High intraindividual variation of B-type natriuretic peptide (BNP) and amino-terminal proBNP in patients with stable chronic heart failure. , 2004, Clinical chemistry.

[118]  C. Bucca,et al.  Asthma severity and medical resource utilisation , 2004, European Respiratory Journal.

[119]  K. Khunti Systematic review of open access echocardiography for primary care , 2004, European journal of heart failure.

[120]  A. Wu,et al.  Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay. , 2003, Clinica chimica acta; international journal of clinical chemistry.

[121]  C. Mcnulty,et al.  Inequalities of primary care microbiology testing between hospital catchment areas , 2003, Journal of clinical pathology.

[122]  Jürgen Stausberg,et al.  Viewpoint Paper: Comparing Paper-based with Electronic Patient Records: Lessons Learned during a Study on Diagnosis and Procedure Codes , 2003, J. Am. Medical Informatics Assoc..

[123]  Bennett P Leifer Early Diagnosis of Alzheimer's Disease: Clinical and Economic Benefits , 2003, Journal of the American Geriatrics Society.

[124]  N Freemantle,et al.  The EuroHeart Failure survey programme-- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. , 2003, European heart journal.

[125]  M J Hensley,et al.  Self-management education and regular practitioner review for adults with asthma. , 2002, The Cochrane database of systematic reviews.

[126]  I. Pavord,et al.  Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids , 2002, Thorax.

[127]  A. Ahmed History of diabetes mellitus. , 2002, Saudi medical journal.

[128]  P Godard,et al.  Costs of asthma are correlated with severity: a 1-yr prospective study , 2002, European Respiratory Journal.

[129]  M. Meltzer Introduction to health economics for physicians , 2001, The Lancet.

[130]  T. Allan,et al.  European survey of primary care physician perceptions on heart failure diagnosis and management (Euro-HF). , 2000, European heart journal.

[131]  G Hultén,et al.  Large Differences in Laboratory Utilisation between Hospitals in Sweden , 2000, Clinical chemistry and laboratory medicine.

[132]  A. Bauman,et al.  Self-management education and regular practitioner review for adults with asthma. , 2000, The Cochrane database of systematic reviews.

[133]  M Plebani,et al.  Mistakes in a stat laboratory: types and frequency. , 1997, Clinical chemistry.

[134]  D. Witte,et al.  Errors, mistakes, blunders, outliers, or unacceptable results: how many? , 1997, Clinical chemistry.

[135]  H. Brodaty,et al.  ALZHEIMER'S DISEASE INTERNATIONAL , 1997, International journal of geriatric psychiatry.

[136]  P J Howanitz,et al.  Reasons for proficiency testing failures in clinical chemistry and blood gas analysis: a College of American Pathologists Q-Probes study in 665 laboratories. , 1996, Archives of pathology & laboratory medicine.

[137]  J. Kassirer,et al.  The threshold approach to clinical decision making. , 1980, The New England journal of medicine.

[138]  S G Pauker,et al.  Clinical application of decision analysis: a detailed illustration. , 1978, Seminars in nuclear medicine.

[139]  F. Sunderman,et al.  A survey of the accuracy of chemical analyses in clinical laboratories. , 1947, Manitoba medical review.