The effects of age and gender on parathyroid hormone dynamics

Hyperparathyroidism is a risk factor for bone loss. An age‐related increase in parathyroid hormone (PTH) level has been demonstrated in several studies. It has been suggested that the type II osteoporotic syndrome, a condition of increased prevalence among elderly women, may be at least partially caused by elevations in intact parathyroid hormone (iPTH) levels. To date, however, the effects of age and gender per se on PTH dynamics in healthy subjects independent of other risk factors such as vitamin D deficiency and/or impaired renal function that can impact on parathyroid function, remain unknown. In this study, we used citrate and calcium (Ca) infusions to characterize the impact of age and gender on PTH dynamics in normal subjects.

[1]  H. Rasmussen,et al.  Calcium retention and hormone levels in black and white women on high‐ and low‐calcium diets , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  M. Burritt,et al.  Role of parathyroid hormone in mediating nocturnal and age-related increases in bone resorption. , 1995, The Journal of clinical endocrinology and metabolism.

[3]  L. Avioli,et al.  Subclinical vitamin D deficiency in postmenopausal women with low vertebral bone mass. , 1991, The Journal of clinical endocrinology and metabolism.

[4]  S. Cummings,et al.  Estrogen Replacement Therapy and Fractures in Older Women , 1995, Annals of Internal Medicine.

[5]  G. Brabant,et al.  Pulse amplitude and frequency modulation of parathyroid hormone in plasma. , 1989, The Journal of clinical endocrinology and metabolism.

[6]  J. Wark,et al.  The prevention and treatment of osteoporosis. , 1993, The New England journal of medicine.

[7]  E. Brown,et al.  The parathyroid hormone circadian rhythm is truly endogenous--a general clinical research center study. , 1997, The Journal of clinical endocrinology and metabolism.

[8]  M. Burritt,et al.  Circadian variation in ionized calcium and intact parathyroid hormone: evidence for sex differences in calcium homeostasis. , 1991, The Journal of clinical endocrinology and metabolism.

[9]  E. Brown,et al.  Racial differences in parathyroid hormone dynamics. , 1994, The Journal of clinical endocrinology and metabolism.

[10]  R. Lepage,et al.  Accumulation of a non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the interpretation of PTH values. , 1996, The Journal of clinical endocrinology and metabolism.

[11]  D. Meier,et al.  Calcium, vitamin D, and parathyroid hormone status in young white and black women: association with racial differences in bone mass. , 1991, The Journal of clinical endocrinology and metabolism.

[12]  S. Epstein,et al.  Evidence for alteration of the vitamin D-endocrine system in obese subjects. , 1985, The Journal of clinical investigation.

[13]  Roger E. Kirk,et al.  Experimental design: Procedures for the behavioral sciences (3rd ed.). , 1995 .

[14]  B. Hollis,et al.  Vitamin D status and related parameters in a healthy population: the effects of age, sex, and season. , 1990, The Journal of clinical endocrinology and metabolism.

[15]  H. Orimo,et al.  [Involutional osteoporosis]. , 1991, Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.

[16]  K.,et al.  Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. , 1981, The Journal of clinical investigation.

[17]  T. A. Roy,et al.  Biochemical parameters associated with low bone density in healthy men and women , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  E. Brown,et al.  Four-parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue. , 1983, The Journal of clinical endocrinology and metabolism.

[19]  T. Clemens,et al.  Skeletal disease in primary hyperparathyroidism , 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  G. Jones,et al.  Reduced creatinine clearance in primary osteoporosis in women , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[21]  F Duboeuf,et al.  Vitamin D3 and calcium to prevent hip fractures in elderly women. , 1992, The New England journal of medicine.

[22]  S. Cummings,et al.  Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. , 1995, The New England journal of medicine.

[23]  Brennan,et al.  Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. , 1987, Clinical chemistry.

[24]  R. Mazess.  Bone densitometry of the axial skeleton. , 1990, The Orthopedic clinics of North America.

[25]  D. Kerr,et al.  The effects of menopause and age on calcitropic hormones: A cross‐sectional study of 655 healthy women aged 35 to 90 , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[26]  S E Whitmore,et al.  Vitamin D deficiency in homebound elderly persons. , 1996, JAMA.

[27]  E. Brown,et al.  Rate and concentration dependence of parathyroid hormone dynamics during stepwise changes in serum ionized calcium in normal humans. , 1990, The Journal of clinical endocrinology and metabolism.

[28]  William G. Cochran,et al.  Experimental Designs, 2nd Edition , 1950 .

[29]  W. O'Fallon,et al.  Effect of age on variables relating to calcium and phosphorus metabolism in women , 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[30]  L. Melton,et al.  Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: a population-based study. , 1997, The Journal of clinical endocrinology and metabolism.

[31]  D. Meier,et al.  Alterations in calcium, vitamin D, and parathyroid hormone physiology in normal men with aging: relationship to the development of senile osteopenia. , 1986, The Journal of clinical endocrinology and metabolism.

[32]  B. Dawson-Hughes,et al.  Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. , 1995, The American journal of clinical nutrition.

[33]  E. Lonergan,et al.  Aging alters calcium regulation of serum concentration of parathyroid hormone in healthy men. , 1997, The American journal of physiology.

[34]  R. Kirk.  Experimental Design: Procedures for the Behavioral Sciences , 1970 .

[35]  E. Siris,et al.  Increased bone mineral density after parathyroidectomy in primary hyperparathyroidism. , 1995, The Journal of clinical endocrinology and metabolism.

[36]  W. Willett,et al.  Caffeine, moderate alcohol intake, and risk of fractures of the hip and forearm in middle-aged women. , 1991, The American journal of clinical nutrition.

[37]  M. Burritt,et al.  Abnormalities in circadian patterns of bone resorption and renal calcium conservation in type I osteoporosis. , 1992, The Journal of clinical endocrinology and metabolism.

[38]  Glenville Jones,et al.  Bone mass is related to creatinine clearance in normal elderly women , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[39]  M. Burritt,et al.  Abnormalities of parathyroid hormone secretion in elderly women that are reversible by short term therapy with 1,25-dihydroxyvitamin D3. , 1994, The Journal of clinical endocrinology and metabolism.

[40]  G. Fuleihan,et al.  Calcidiol and PTH Levels in Women Attending an Osteoporosis Program , 1999, Calcified Tissue International.

[41]  E. Brown,et al.  Relationship between the concentration and rate of change of calcium and serum intact parathyroid hormone levels in normal humans. , 1988, The Journal of clinical endocrinology and metabolism.