Four different synthetic peptides of proteolipid protein induce a distinct antibody response in MP4-induced experimental autoimmune encephalomyelitis.

[1]  M. Sospedra,et al.  Immunology of Multiple Sclerosis , 2016, Seminars in Neurology.

[2]  P. Lehmann,et al.  The complement system contributes to the pathology of experimental autoimmune encephalomyelitis by triggering demyelination and modifying the antigen-specific T and B cell response. , 2013, Clinical immunology.

[3]  M. Levin,et al.  Antibodies to an Intracellular Antigen Penetrate Neuronal Cells and Cause Deleterious Effects , 2013 .

[4]  P. Lehmann,et al.  Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response , 2012, Acta Neuropathologica.

[5]  I. Cohen,et al.  Antigen microarrays identify CNS-produced autoantibodies in RRMS , 2012, Neurology.

[6]  R. Reynolds,et al.  Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. , 2011, Brain : a journal of neurology.

[7]  P. Lehmann,et al.  Myelin-reactive antibodies mediate the pathology of MBP-PLP fusion protein MP4-induced EAE. , 2011, Clinical immunology.

[8]  M. Dalakas,et al.  Fine specificity of antibodies against AQP4: epitope mapping reveals intracellular epitopes. , 2011, Journal of autoimmunity.

[9]  K. Addicks,et al.  Corrigendum to “Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm” [Ann. Anat. 192 (4) (2010) 179–193] , 2011 .

[10]  S. Cepok,et al.  The role of antibodies in multiple sclerosis. , 2011, Biochimica et biophysica acta.

[11]  D. Cornblath,et al.  Evidence-based guideline update: Plasmapheresis in neurologic disorders , 2011, Neurology.

[12]  T. Chomiak,et al.  What Is the Optimal Value of the g-Ratio for Myelinated Fibers in the Rat CNS? A Theoretical Approach , 2009, PloS one.

[13]  K. Berer,et al.  Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells , 2009, The Journal of experimental medicine.

[14]  J. Rosenbluth,et al.  Spinal cord dysmyelination caused by an antiproteolipid protein IgM antibody: Implications for the mechanism of central nervous system myelin formation , 2009, Journal of neuroscience research.

[15]  P. Lehmann,et al.  Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis. , 2008, Clinical immunology.

[16]  D. Arnold,et al.  B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. , 2008, The New England journal of medicine.

[17]  R. Soleti,et al.  Fcgamma receptors mediate internalization of anti-Ro and anti-La autoantibodies from Sjögren's syndrome and apoptosis in human salivary gland cell line A-253. , 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[18]  Hans Lassmann,et al.  Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. , 2006, Brain : a journal of neurology.

[19]  P. Lehmann,et al.  MBP-PLP fusion protein-induced EAE in C57BL/6 mice , 2006, Journal of Neuroimmunology.

[20]  Lawrence Steinman,et al.  How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis , 2006, Annals of neurology.

[21]  S. Miller,et al.  Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis , 2005, Nature Medicine.

[22]  D. Alarcón-Segovia,et al.  Antibody penetration into living cells: pathogenic, preventive and immuno-therapeutic implications. , 2003, Current pharmaceutical design.

[23]  Lawrence Steinman,et al.  Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis , 2003, Nature Biotechnology.

[24]  N. Ruddle,et al.  Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice1 , 2003, Journal of Immunology.

[25]  B. Trapp,et al.  Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease , 2003, Journal of the Neurological Sciences.

[26]  Michael J. Ramsbottom,et al.  Critical role of antigen‐specific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoprotein , 2002, European journal of immunology.

[27]  S. Hauser,et al.  Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[28]  S. Miller,et al.  De Novo Central Nervous System Processing of Myelin Antigen Is Required for the Initiation of Experimental Autoimmune Encephalomyelitis1 , 2002, The Journal of Immunology.

[29]  R. Maxwell,et al.  Marmoset Fine B Cell and T Cell Epitope Specificities Mapped onto a Homology Model of the Extracellular Domain of Human Myelin Oligodendrocyte Glycoprotein , 2002, Neurobiology of Disease.

[30]  J. Parisi,et al.  Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination , 2000, Annals of neurology.

[31]  I. Sanz,et al.  In vivo cell penetration and intracellular transport of anti-Sm and anti-La autoantibodies. , 2000, International immunology.

[32]  R. Hohlfeld,et al.  Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. , 1999, Brain : a journal of neurology.

[33]  A. Cross,et al.  B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide , 1999, European journal of immunology.

[34]  A. Steck,et al.  Anti‐MAG IgM penetration into myelinated fibers correlates with the extent of myelin widening , 1999, Muscle & nerve.

[35]  V. Tuohy,et al.  Spontaneous Regression of Primary Autoreactivity during Chronic Progression of Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis , 1999, The Journal of experimental medicine.

[36]  P. Dalbon,et al.  Specificities of multiple sclerosis cerebrospinal fluid and serum antibodies against mimotopes , 1998, Journal of Neuroimmunology.

[37]  L. Matis,et al.  Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes. , 1998, Journal of immunology.

[38]  R. Tafi,et al.  Identification of peptides binding to IgG in the CSF of Multiple Sclerosis patients , 1998, Multiple sclerosis.

[39]  R. Rudick,et al.  Axonal transection in the lesions of multiple sclerosis. , 1998, The New England journal of medicine.

[40]  H. Hartung,et al.  Isolation and characterization of an oligodendrocyte precursor–derived B‐cell epitope in multiple sclerosis , 1998, Annals of neurology.

[41]  H. Lassmann,et al.  Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[42]  D. Colman,et al.  Conservation of Topology, But Not Conformation, of the Proteolipid Proteins of the Myelin Sheath , 1997, The Journal of Neuroscience.

[43]  L. Matis,et al.  Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein. , 1996, The Journal of clinical investigation.

[44]  C. Richter-Landsberg,et al.  OLN‐93: A new permanent oligodendroglia cell line derived from primary rat brain glial cultures , 1996, Journal of neuroscience research.

[45]  D. Alarcón-Segovia,et al.  The penetration of autoantibodies into cells may induce tolerance to self by apoptosis of autoreactive lymphocytes and cause autoimmune disease by dysregulation and/or cell damage. , 1996, Journal of autoimmunity.

[46]  M. Pákáski,et al.  Identification and characterization of a B‐cell determinant within the amphipathic domain (residues 178–238) of the myelin proteolipid protein , 1996, Journal of neuroscience research.

[47]  D. Isenberg,et al.  Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. , 1995, Kidney international.

[48]  F. Lieberman,et al.  Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity , 1994, Journal of Neuroimmunology.

[49]  E. Sercarz,et al.  Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen , 1992, Nature.

[50]  G. M. Hope,et al.  Maintenance of myelinated fibre g ratio in acute experimental allergic encephalomyelitis. , 1991, Brain : a journal of neurology.

[51]  M. K. Richards,et al.  The immune response to myelin proteolipid protein in the Lewis rat: identification of the immunodominant B cell epitope , 1990, Journal of Neuroimmunology.

[52]  P. Ho,et al.  Lessons learned from studies of natural resistance in murine experimental autoimmune encephalomyelitis. , 2012, Current trends in immunology.

[53]  R. Reynolds,et al.  Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. , 2007, Brain : a journal of neurology.