Peripheral mechanisms of satiation and satiety control.

Abstract: After food intake anorexogenic peptides are released (CCK, PYY and GLP-1) and before food intake the orexogenic peptide ghrelin increases in plasma. The mechanism of release and effects on appetite will be discussed, as well as effects on the motility of the gastrointestinal tract. Bariatric surgery (gastric bypass) will be used as a model to explore the potential effects of alterations in the release of gut peptides on satiation, satiety and hunger within the scope of the Satiety Cascade.

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