NMDA enhances stretching-induced differentiation of osteoblasts through the ERK1/2 signaling pathway.

[1]  J. McDonald,et al.  Modeled microgravity disrupts collagen I/integrin signaling during osteoblastic differentiation of human mesenchymal stem cells , 2013, Journal of cellular biochemistry.

[2]  Tatsuji Nishihara,et al.  Mechanical stress‐mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts , 2007, Journal of cellular biochemistry.

[3]  Suk-Ho Lee,et al.  Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells , 2007, Journal of Cell Science.

[4]  E. Hinoi,et al.  Glutamate suppresses osteoclastogenesis through the cystine/glutamate antiporter. , 2007, The American journal of pathology.

[5]  Lutz Claes,et al.  Signal transduction pathways involved in mechanotransduction in bone cells. , 2006, Biochemical and biophysical research communications.

[6]  Robert A. Smith,et al.  Hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells: The effects of glutamate and protection by purines. , 2006, Bone.

[7]  Lin Tang,et al.  Effects of different magnitudes of mechanical strain on Osteoblasts in vitro. , 2006, Biochemical and biophysical research communications.

[8]  J. Rubin,et al.  Response to mechanical strain in an immortalized pre‐osteoblast cell is dependent on ERK1/2 , 2006, Journal of cellular physiology.

[9]  L. Claes,et al.  Signal transduction pathways involved in mechanical regulation of HB-GAM expression in osteoblastic cells. , 2006, Biochemical and biophysical research communications.

[10]  Janet Rubin,et al.  Molecular pathways mediating mechanical signaling in bone. , 2006, Gene.

[11]  J. Haddad.  N-methyl-d-aspartate (NMDA) and the regulation of mitogen-activated protein kinase (MAPK) signaling pathways: A revolving neurochemical axis for therapeutic intervention? , 2005, Progress in Neurobiology.

[12]  S. Dudek,et al.  Pattern-Dependent Role of NMDA Receptors in Action Potential Generation: Consequences on Extracellular Signal-Regulated Kinase Activation , 2005, The Journal of Neuroscience.

[13]  H. Weinans,et al.  Stretch‐induced phosphorylation of ERK1/2 depends on differentiation stage of osteoblasts , 2004, Journal of cellular biochemistry.

[14]  Laurence Vico,et al.  Mechanical Strain on Osteoblasts Activates Autophosphorylation of Focal Adhesion Kinase and Proline-rich Tyrosine Kinase 2 Tyrosine Sites Involved in ERK Activation* , 2004, Journal of Biological Chemistry.

[15]  Q. Tang,et al.  Glutamate signaling to ras-MAPK in striatal neurons , 2004, Molecular Neurobiology.

[16]  Janet Rubin,et al.  Mechanical Strain Differentially Regulates Endothelial Nitric-oxide Synthase and Receptor Activator of Nuclear κB Ligand Expression via ERK1/2 MAPK* , 2003, Journal of Biological Chemistry.

[17]  E. Hinoi,et al.  Modulation of cellular differentiation by N‐methyl‐d‐aspartate receptors in osteoblasts , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  J. Baek,et al.  p44/42 MAPK activation is necessary for receptor activator of nuclear factor-kappaB ligand induction by high extracellular calcium. , 2003, Biochemical and biophysical research communications.

[19]  H. Weinans,et al.  Mechanical Control of Human Osteoblast Apoptosis and Proliferation in Relation to Differentiation , 2003, Calcified Tissue International.

[20]  K. Lau,et al.  Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. , 2003, Bone.

[21]  G. Xiao,et al.  Regulation of the osteoblast‐specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways , 2003, Journal of cellular biochemistry.

[22]  M. Hughes-Fulford,et al.  A Short Pulse of Mechanical Force Induces Gene Expression and Growth in MC3T3‐E1 Osteoblasts via an ERK 1/2 Pathway , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  J. Frangos,et al.  Temporal gradients in shear stimulate osteoblastic proliferation via ERK1/2 and retinoblastoma protein. , 2002, American journal of physiology. Endocrinology and metabolism.

[24]  W. R. Taylor,et al.  Activation of Extracellular Signal–Regulated Kinase Is Involved in Mechanical Strain Inhibition of RANKL Expression in Bone Stromal Cells , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[25]  L. Lanyon,et al.  Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. , 2002, Bone.

[26]  Dimitris Kletsas,et al.  The Bone-specific Transcriptional Regulator Cbfa1 Is a Target of Mechanical Signals in Osteoblastic Cells* , 2002, The Journal of Biological Chemistry.

[27]  S. Sheen-Chen,et al.  Superoxide Mediates Shock Wave Induction of ERK-dependent Osteogenic Transcription Factor (CBFA1) and Mesenchymal Cell Differentiation toward Osteoprogenitors* , 2002, The Journal of Biological Chemistry.

[28]  P. Genever,et al.  The NMDA Type Glutamate Receptors Expressed by Primary Rat Osteoblasts Have the Same Electrophysiological Characteristics as Neuronal Receptors , 2002, Calcified Tissue International.

[29]  M. Fürthauer,et al.  Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling , 2002, Nature Cell Biology.

[30]  G. Karsenty,et al.  Physical Interaction of the Activator Protein-1 Factors c-Fos and c-Jun with Cbfa1 for Collagenase-3 Promoter Activation* , 2002, The Journal of Biological Chemistry.

[31]  Ching‐Jen Wang,et al.  Physical shock wave mediates membrane hyperpolarization and Ras activation for osteogenesis in human bone marrow stromal cells. , 2001, Biochemical and biophysical research communications.

[32]  H J Donahue,et al.  Osteopontin Gene Regulation by Oscillatory Fluid Flow via Intracellular Calcium Mobilization and Activation of Mitogen-activated Protein Kinase in MC3T3–E1 Osteoblasts* , 2001, The Journal of Biological Chemistry.

[33]  E. Hinoi,et al.  Consolidation of transient ionotropic glutamate signals through nuclear transcription factors in the brain , 2001, Progress in Neurobiology.

[34]  E. Hinoi,et al.  Group III metabotropic glutamate receptors in rat cultured calvarial osteoblasts. , 2001, Biochemical and biophysical research communications.

[35]  E. Brown,et al.  Activation of p42/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line. , 2000, Biochemical and biophysical research communications.

[36]  T. Skerry,et al.  The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  P. Delmas,et al.  Active NMDA glutamate receptors are expressed by mammalian osteoclasts , 1999, The Journal of physiology.

[38]  H J Donahue,et al.  Differential effect of steady versus oscillating flow on bone cells. , 1998, Journal of biomechanics.

[39]  P. Han,et al.  Ca2+‐Mediated Activation of c‐Jun N‐Terminal Kinase and Nuclear Factor κB by NMDA in Cortical Cell Cultures , 1998, Journal of neurochemistry.

[40]  L. Suva,et al.  Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone. , 1998, Bone.

[41]  Y. Mikuni‐Takagaki,et al.  Mechanotransduction in stretched osteocytes--temporal expression of immediate early and other genes. , 1998, Biochemical and biophysical research communications.

[42]  P. Delmas,et al.  Glutamate receptors are expressed by bone cells and are involved in bone resorption. , 1998, Bone.

[43]  D. Burr,et al.  Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain. , 1997, The American journal of physiology.

[44]  L. Lanyon,et al.  Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. , 1996, Bone.

[45]  J. R. Fisher,et al.  The Biochemical Pathway Mediating the Proliferative Response of Bone Cells to a Mechanical Stimulus* , 1996, The Journal of bone and joint surgery. American volume.

[46]  A. Pitsillides,et al.  Mechanical strain‐induced NO production by bone cells: a possible role in adaptive bone (re)modeling? , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[47]  C. Turner,et al.  Mechanotransduction and the functional response of bone to mechanical strain , 1995, Calcified Tissue International.

[48]  A. van der Plas,et al.  Sensitivity of osteocytes to biomechanical stress in vitro , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  P. Seeburg,et al.  Mammalian ionotropic glutamate receptors , 1993, Current Opinion in Neurobiology.

[50]  H. Frost,et al.  Perspectives: bone's mechanical usage windows. , 1992, Bone and mineral.

[51]  D. Jones,et al.  Biochemical signal transduction of mechanical strain in osteoblast-like cells. , 1991, Biomaterials.

[52]  R. Axel,et al.  A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties , 1990, Neuron.

[53]  S. Heinemann,et al.  Cloning by functional expression of a member of the glutamate receptor family , 1989, Nature.

[54]  S. Katz,et al.  Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation. , 2006, The international journal of biochemistry & cell biology.

[55]  S. K. Zaidi,et al.  Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. , 2004, Critical reviews in eukaryotic gene expression.

[56]  T. Komori.  Requisite roles of Runx2 and Cbfb in skeletal development , 2003, Journal of Bone and Mineral Metabolism.

[57]  G. Xiao,et al.  Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation. , 2003, Connective tissue research.

[58]  A. Papavassiliou,et al.  Stretch-mediated Activation of Selective MAPK Subtypes and Potentiation of AP-1 Binding in Human Osteoblastic Cells , 2001, Molecular medicine.

[59]  R. Brand,et al.  Primary human bone cultures from older patients do not respond at continuum levels of in vivo strain magnitudes. , 2000, Journal of biomechanics.

[60]  T D Brown,et al.  Techniques for mechanical stimulation of cells in vitro: a review. , 2000, Journal of biomechanics.

[61]  E H Burger,et al.  Signal transduction pathways involved in fluid flow-induced PGE2 production by cultured osteocytes. , 1999, American journal of physiology. Endocrinology and metabolism.