A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

Tien Yin Wong | Wiro J Niessen | Charles DeCarli | Jeroen van der Grond | Neda Jahanshad | Reinhold Schmidt | Sudha Seshadri | Qiong Yang | Zdenka Pausova | Fabrice Crivello | Vilmundur Gudnason | Bernard Mazoyer | Tamara B Harris | Oscar L Lopez | Konstantinos Arfanakis | Bruce M Psaty | Rasika A Mathias | Philippe Amouyel | Paul M Thompson | Cornelia M van Duijn | Edith Hofer | Lenore J Launer | Joshua C Bis | Paul A Nyquist | Saima Hilal | Gennady V Roshchupkin | Claudia L Satizabal | Ganesh Chauhan | Philip L De Jager | M Kamran Ikram | Helena Schmidt | Lei Yu | Marian Beekman | Erik B van den Akker | Stefan Boehringer | Diana van Heemst | Najaf Amin | Yasaman Saba | Derrek P Hibar | M Arfan Ikram | Pauline Maillard | Tomas Paus | C. DeCarli | N. Jahanshad | P. Thompson | T. Paus | V. Gudnason | Albert Vernon Smith | Stefan Boehringer | T. Wong | Qiong Yang | B. Mazoyer | F. Crivello | K. Arfanakis | O. Lopez | B. Psaty | W. Niessen | D. Hibar | K. Taylor | T. Harris | P. Amouyel | D. Becker | K. Rice | M. Beekman | P. Slagboom | C. V. van Duijn | P. D. De Jager | Z. Pausova | P. Maillard | R. Schmidt | H. Schmidt | M. Vernooij | M. Ikram | A. Beiser | J. Bis | N. Amin | Lei Yu | L. Launer | S. Seshadri | Ching-Yu Cheng | L. Yanek | R. Mathias | J. Cheung | M. Bernard | Hieab H. H. Adams | G. Chauhan | C. Satizabal | P. Nyquist | S. Debette | D. van Heemst | J. van der Grond | M. Ikram | W. Longstreth | Christopher L H Chen | E. Hofer | G. Roshchupkin | S. Hilal | S. J. van der Lee | Wanting Zhao | E. B. van den Akker | Y. Saba | Diane M Becker | P Eline Slagboom | Manon Bernard | Alexa S Beiser | Wanting Zhao | Meike W Vernooij | Lisa R Yanek | Sven J van der Lee | Stéphanie Debette | Hieab H H Adams | Maria J Knol | Christopher Chen | Kent D Taylor | Ken Rice | W T Longstreth | M. Knol | Josh W Cheung | Ching Yu Cheng | Shuo Li | David A Bennett | Shuo Li | A. Smith | D. Bennett

[1]  John P. Rice,et al.  Identification of common genetic risk variants for autism spectrum disorder , 2019, Nature Genetics.

[2]  Alicia R. Martin,et al.  Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder , 2018, Nature Genetics.

[3]  Warren W. Kretzschmar,et al.  Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression , 2017, Nature Genetics.

[4]  John P. Rice,et al.  Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes 1 2 Primary , 2018 .

[5]  P. Visscher,et al.  Multi-trait analysis of genome-wide association summary statistics using MTAG , 2017, Nature Genetics.

[6]  M. Nalls,et al.  A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci , 2017, Nature Genetics.

[7]  Benjamin S Aribisala,et al.  Novel genetic loci associated with hippocampal volume , 2017, Nature Communications.

[8]  Benjamin S Aribisala,et al.  Novel genetic loci underlying human intracranial volume identified through genome-wide association , 2016, Nature Neuroscience.

[9]  Anbupalam Thalamuthu,et al.  Distinct Genetic Influences on Cortical and Subcortical Brain Structures , 2016, Scientific Reports.

[10]  Tom R. Gaunt,et al.  LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis , 2016, bioRxiv.

[11]  Ronald M Peshock,et al.  Cardiovascular Risk Factors Associated with Smaller Brain Volumes in Regions Identified as Early Predictors of Cognitive Decline. , 2016, Radiology.

[12]  Mitchell J. Machiela,et al.  LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants , 2015, Bioinform..

[13]  Gabor T. Marth,et al.  A global reference for human genetic variation , 2015, Nature.

[14]  A. V. D. van den Ouweland,et al.  Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability , 2015, American journal of human genetics.

[15]  G. Kempermann.  Faculty Opinions recommendation of Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. , 2015 .

[16]  Jun S. Liu,et al.  The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans , 2015, Science.

[17]  Thomas E. Nichols,et al.  Common genetic variants influence human subcortical brain structures , 2015, Nature.

[18]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[19]  Lorna M. Lopez,et al.  Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI , 2015, Circulation. Cardiovascular genetics.

[20]  A Hofman,et al.  Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) , 2015, Molecular Psychiatry.

[21]  David M. Evans,et al.  A novel common variant in DCST2 is associated with length in early life and height in adulthood , 2014, Human molecular genetics.

[22]  Zoltán Kutalik,et al.  Quality control and conduct of genome-wide association meta-analyses , 2014, Nature Protocols.

[23]  Margaret J. Wright,et al.  Heritability of brain volumes in older adults: the Older Australian Twins Study , 2014, Neurobiology of Aging.

[24]  Nick C Fox,et al.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.

[25]  Daniel L. Koller,et al.  Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture , 2012, Nature Genetics.

[26]  P. Visscher,et al.  Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits , 2012, Nature Genetics.

[27]  Manolis Kellis,et al.  HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants , 2011, Nucleic Acids Res..

[28]  Thomas Meitinger,et al.  Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution , 2011, Nature Genetics.

[29]  P. Visscher,et al.  GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.

[30]  Alan C. Evans,et al.  Lateralized genetic and environmental influences on human brain morphology of 8-year-old twins , 2010, NeuroImage.

[31]  Thomas Meitinger,et al.  Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution , 2010, Nature Genetics.

[32]  Ayellet V. Segrè,et al.  Hundreds of variants clustered in genomic loci and biological pathways affect human height , 2010, Nature.

[33]  Christian Gieger,et al.  Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels , 2010, PLoS genetics.

[34]  Martin Styner,et al.  r Human Brain Mapping 000:000–000 (2010) r Genetic and Environmental Contributions to Neonatal Brain Structure: A Twin Study* , 2022 .

[35]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[36]  C. DeCarli,et al.  Bivariate Heritability of Total and Regional Brain Volumes: The Framingham Study , 2009, Alzheimer disease and associated disorders.

[37]  M. Haber,et al.  Localization of the Diaphanous-related formin Daam1 to neuronal dendrites , 2008, Neuroscience Letters.

[38]  Wiro J. Niessen,et al.  Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification , 2007, NeuroImage.

[39]  Alan C. Evans,et al.  S.27.05 Genetic contributions to human brain morphology and intelligence , 2006, European Neuropsychopharmacology.

[40]  Essi Viding,et al.  A pediatric twin study of brain morphometry. , 2006, Journal of child psychology and psychiatry, and allied disciplines.

[41]  Anders M. Dale,et al.  An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest , 2006, NeuroImage.

[42]  Kenneth F. Valyear,et al.  Human parietal cortex in action , 2006, Current Opinion in Neurobiology.

[43]  F. Jankovics,et al.  The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton , 2006, Development.

[44]  T. Ogura,et al.  Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system. , 2004, Brain research. Developmental brain research.

[45]  K. Millen,et al.  Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation , 2004, Nature Genetics.

[46]  L. Squire,et al.  The anatomy of semantic knowledge: medial vs. lateral temporal lobe. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[47]  Nikos Makris,et al.  Automatically parcellating the human cerebral cortex. , 2004, Cerebral cortex.

[48]  Anne Williamson,et al.  A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories , 2003, Epilepsia.

[49]  D. Geschwind,et al.  Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[50]  Yoichi Kato,et al.  Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1 , 2001, Cell.

[51]  R. Kahn,et al.  Quantitative genetic modeling of variation in human brain morphology. , 2001, Cerebral cortex.

[52]  E. Miller,et al.  An integrative theory of prefrontal cortex function. , 2001, Annual review of neuroscience.

[53]  L. Almasy,et al.  Multipoint quantitative-trait linkage analysis in general pedigrees. , 1998, American journal of human genetics.

[54]  M. Mendez,et al.  Pick's disease versus Alzheimer's disease , 1993, Neurology.

[55]  L. Borges,et al.  Effect of Magnesium on Epileptic Foci , 1978, Epilepsia.

[56]  J. Pritchard,et al.  Standardized treatment of 154 consecutive cases of eclampsia. , 1975, American journal of obstetrics and gynecology.