Intrauterine MRI with single-shot fast-spin echo imaging showed different signal intensities in hypoplastic lungs

Abstract Ultrasonography is used for the prenatal diagnosis of hypoplastic lungs. However, ultrasound poses problems because of difficulties in getting the entire lung in perspective and the results depend on the skill of the examiner. When the alveolar formation of the fetal lung is retarded, the fetus is predicted to show an altered density on MRI using an SSFSE sequence due to a varied amount of alveolar lung fluid. We present a case of twins who showed a marked difference in signal intensity of the lung on MRI, which was useful for predicting the fetal pathophysiology. Intrauterine MRI provides the possibility of diagnosing hypoplastic lungs prenatally.

[1]  P. Gowland,et al.  The changes in magnetic resonance properties of the fetal lungs: a first result and a potential tool for the non‐invasive in utero demonstration of fetal lung maturation , 1999, British journal of obstetrics and gynaecology.

[2]  M. Ladd,et al.  Prenatal diagnosis of fetal malformations by ultrafast magnetic resonance imaging , 1998, Prenatal diagnosis.

[3]  A. Hubbard,et al.  Prenatal magnetic resonance imaging enhances fetal diagnosis. , 1998, Journal of pediatric surgery.

[4]  A. Hubbard,et al.  Prenatal MRI Evaluation of Giant Neck Masses in Preparation for the Fetal Exit Procedure , 1998, American journal of perinatology.

[5]  K. Partanen,et al.  Fetal intracranial hemorrhage. Imaging by ultrasound and magnetic resonance imaging. , 1997, The Journal of reproductive medicine.

[6]  R. Hirschl,et al.  Prenatal ultrasonography frequently fails to diagnose congenital diaphragmatic hernia. , 1997, Journal of pediatric surgery.

[7]  Duncan Kr The development of magnetic resonance imaging in obstetrics. , 1996 .

[8]  K. Duncan The development of magnetic resonance imaging in obstetrics. , 1996, British journal of hospital medicine.

[9]  Y. Chiba,et al.  Use of Lung‐Thorax Transverse Area Ratio in the Antenatal Evaluation of Lung Hypoplasia in Congenital Diaphragmatic Hernia , 1990, Journal of clinical ultrasound : JCU.

[10]  T. Wakabayashi,et al.  Lung Hypoplasia in Developing Mice and Rats Induced by Maternal Exposure to Nitrofen , 1990 .