CARDIAC EFFECTS OF INTRACORONARY ARTERIAL INJECTIONS OF NICOTINE *

The purpose of this study was to determine the cardiac effects of nicotine by direct coronary artery injection. This method has the advantage of elucidating certain direct cardiac effects independent of systemic changes. The procedure previously described from this laboratory involves the ability to inject minute amounts of drugs or dye into various coronary branches of dogs without opening their chests or interfering with perivascular nerves.'*2