Mixtures of prion substrains in natural scrapie cases revealed by ovinised murine models

[1]  H. Laude,et al.  Divergent prion strain evolution driven by PrPC expression level in transgenic mice , 2017, Nature Communications.

[2]  N. Hunter,et al.  Stability of murine scrapie strain 87V after passage in sheep and comparison with the CH1641 ovine strain. , 2015, The Journal of general virology.

[3]  M. Simmons,et al.  Phenotype Shift from Atypical Scrapie to CH1641 following Experimental Transmission in Sheep , 2015, PloS one.

[4]  O. Andréoletti,et al.  Evidence for zoonotic potential of ovine scrapie prions , 2014, Nature Communications.

[5]  N. Makarava,et al.  Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrPSc Glycoform and Prion Infectivity , 2014, PLoS pathogens.

[6]  Thomas M. Holder,et al.  In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation , 2012, BMC Veterinary Research.

[7]  J. Spiropoulos,et al.  Evidence for co-infection of ovine prion strains in classical scrapie isolates. , 2012, Journal of comparative pathology.

[8]  J. Spiropoulos,et al.  Propagation of ovine prions from "poor" transmitter scrapie isolates in ovine PrP transgenic mice. , 2012, Experimental and molecular pathology.

[9]  J. Spiropoulos,et al.  Selection of Distinct Strain Phenotypes in Mice Infected by Ovine Natural Scrapie Isolates Similar to CH1641 Experimental Scrapie , 2012, Journal of neuropathology and experimental neurology.

[10]  H. Laude,et al.  Facilitated Cross-Species Transmission of Prions in Extraneural Tissue , 2012, Science.

[11]  Thomas M. Holder,et al.  Use of Murine Bioassay to Resolve Ovine Transmissible Spongiform Encephalopathy Cases Showing a Bovine Spongiform Encephalopathy Molecular Profile , 2011, Brain pathology.

[12]  T. Baron,et al.  Histopathological Studies of “CH1641-Like” Scrapie Sources Versus Classical Scrapie and BSE Transmitted to Ovine Transgenic Mice (TgOvPrP4) , 2011, PloS one.

[13]  J. Spiropoulos,et al.  Emergence of multiple prion strains from single isolates of ovine scrapie. , 2011, The Journal of general virology.

[14]  R. Bolea,et al.  An assessment of the efficiency of PrPsc detection in rectal mucosa and third-eyelid biopsies from animals infected with scrapie. , 2011, Veterinary microbiology.

[15]  Y. Matsuura,et al.  Intraspecies Prion Transmission Results in Selection of Sheep Scrapie Strains , 2010, PloS one.

[16]  Charles Weissmann,et al.  Darwinian Evolution of Prions in Cell Culture , 2010, Science.

[17]  M. Nöremark,et al.  The prevalence of atypical scrapie in sheep from positive flocks is not higher than in the general sheep population in 11 European countries , 2010, BMC veterinary research.

[18]  J. Spiropoulos,et al.  Molecular and Transmission Characteristics of Primary-Passaged Ovine Scrapie Isolates in Conventional and Ovine PrP Transgenic Mice , 2008, Journal of Virology.

[19]  M. Nöremark,et al.  Atypical/Nor98 scrapie: properties of the agent, genetics, and epidemiology. , 2008, Veterinary research.

[20]  A. Buschmann,et al.  Rodent models for prion diseases. , 2008, Veterinary research.

[21]  H. Laude,et al.  Prion agent diversity and species barrier. , 2008, Veterinary research.

[22]  Didier Calavas,et al.  A descriptive study of the prevalence of atypical and classical scrapie in sheep in 20 European countries , 2008, BMC veterinary research.

[23]  J. Manson,et al.  Host PrP Glycosylation: A Major Factor Determining the Outcome of Prion Infection , 2008, PLoS biology.

[24]  H. Laude,et al.  Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD , 2008, PloS one.

[25]  John Collinge,et al.  A General Model of Prion Strains and Their Pathogenicity , 2007, Science.

[26]  O. Andréoletti,et al.  Classic Scrapie in Sheep with the ARR/ARR Prion Genotype in Germany and France , 2007, Emerging infectious diseases.

[27]  A. Buschmann,et al.  Amino acid sequence and prion strain specific effects on the in vitro and in vivo convertibility of ovine/murine and bovine/murine prion protein chimeras. , 2007, Biochimica et biophysica acta.

[28]  T. Baron,et al.  Molecular Behaviors of “CH1641-Like” Sheep Scrapie Isolates in Ovine Transgenic Mice (TgOvPrP4) , 2007, Journal of Virology.

[29]  D. Calavas,et al.  Scrapie strain transmission studies in ovine PrP transgenic mice reveal dissimilar susceptibility , 2007, Histochemistry and Cell Biology.

[30]  B. Ghetti,et al.  Accumulation of prion protein in the brain that is not associated with transmissible disease , 2007, Proceedings of the National Academy of Sciences.

[31]  H. Laude,et al.  Isolation from Cattle of a Prion Strain Distinct from That Causing Bovine Spongiform Encephalopathy , 2006, PLoS pathogens.

[32]  A. Aguzzi,et al.  Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease , 2005, The Lancet Neurology.

[33]  P. Sarradin,et al.  A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[34]  E. Masliah,et al.  Anchorless Prion Protein Results in Infectious Amyloid Disease Without Clinical Scrapie , 2005, Science.

[35]  S. Prusiner,et al.  Transmission Barriers for Bovine, Ovine, and Human Prions in Transgenic Mice , 2005, Journal of Virology.

[36]  J. Collinge,et al.  Subclinical prion infection. , 2003, Trends in microbiology.

[37]  M. Jeffrey,et al.  Distinct profiles of PrP(d) immunoreactivity in the brain of scrapie- and BSE-infected sheep: implications for differential cell targeting and PrP processing. , 2003, The Journal of general virology.

[38]  G. Forloni,et al.  Molecular analysis of iatrogenic scrapie in Italy. , 2003, The Journal of general virology.

[39]  M. Jeffrey,et al.  Cell-associated variants of disease-specific prion protein immunolabelling are found in different sources of sheep transmissible spongiform encephalopathy. , 2003, The Journal of general virology.

[40]  D. Dormont,et al.  Differences in the activation of the GFAP gene promoter by prion and viral infections. , 2002, Brain research. Molecular brain research.

[41]  S. Bellworthy,et al.  Distinction of scrapie phenotypes in sheep by lesion profiling. , 2002, Journal of comparative pathology.

[42]  S. Cousens,et al.  Strain characterization of natural sheep scrapie and comparison with BSE. , 2002, The Journal of general virology.

[43]  H. Laude,et al.  Markedly Increased Susceptibility to Natural Sheep Scrapie of Transgenic Mice Expressing Ovine PrP , 2001, Journal of Virology.

[44]  G. Forloni,et al.  Evidence for the transmission of scrapie to sheep and goats from a vaccine against Mycoplasma agalactiae , 2001, Veterinary Record.

[45]  P. Lantos,et al.  Microglia and the pathogenesis of spongiform encephalopathies , 2001, Brain Research Reviews.

[46]  J. Grosclaude,et al.  Early accumulation of PrP(Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie. , 2000, The Journal of general virology.

[47]  M. Tranulis,et al.  Distribution of prion protein in the ileal Peyer's patch of scrapie-free lambs and lambs naturally and experimentally exposed to the scrapie agent. , 2000, The Journal of general virology.

[48]  P. Lantos,et al.  Species-barrier-independent prion replication in apparently resistant species. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[49]  U. Agrimi,et al.  Epidemic of transmissible spongiform encephalopathy in sheep and goats in Italy , 1999, The Lancet.

[50]  S. Priola.  Prion protein and species barriers in the transmissible spongiform encephalopathies. , 1999, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[51]  Stanley B. Prusiner,et al.  Nobel Lecture: Prions , 1998 .

[52]  J. Collinge,et al.  Molecular screening of sheep for bovine spongiform encephalopathy , 1998, Neuroscience Letters.

[53]  J. Wood,et al.  Neuropathology of scrapie: a study of the distribution patterns of brain lesions in 222 cases of natural scrapie in sheep, 1982–1991 , 1997, Veterinary Record.

[54]  S. Prusiner,et al.  Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity , 1996, Science.

[55]  K. Jellinger,et al.  Neuropathological Diagnostic Criteria for Creutzfeldt‐Jakob Disease (CJD) and Other Human Spongiform Encephalopathies (Prion Diseases) , 1995, Brain pathology.

[56]  R. Marsh,et al.  Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy , 1994, Journal of virology.

[57]  D. Dormont,et al.  Astrocyte gene expression in experimental mouse scrapie. , 1994, Journal of comparative pathology.

[58]  M. Bruce,et al.  Scrapie strain variation and mutation. , 1993, British medical bulletin.

[59]  R. Marsh,et al.  Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters. , 1992, The Journal of general virology.

[60]  S. Prusiner,et al.  Molecular biology of prion diseases , 1991, Science.

[61]  J. Foster,et al.  The unusual properties of CH1641, a sheep-passaged isolate of scrapie , 1988, Veterinary Record.

[62]  Stanley B. Prusiner,et al.  Scrapie prion protein contains a phosphatidylinositol glycolipid , 1987, Cell.

[63]  Ruedi Aebersold,et al.  A cellular gene encodes scrapie PrP 27-30 protein , 1985, Cell.

[64]  S. Prusiner.  Novel proteinaceous infectious particles cause scrapie. , 1982, Science.

[65]  H. Fraser,et al.  The sequential development of the brain lesion of scrapie in three strains of mice. , 1968, Journal of comparative pathology.

[66]  J. Hope,et al.  Short Communication Characterization of atypical scrapie cases from Great Britain in transgenic ovine PrP mice , 2010 .

[67]  N. Hunter,et al.  Ovine infection with the agents of scrapie (CH1641 isolate) and bovine spongiform encephalopathy: immunochemical similarities can be resolved by immunohistochemistry. , 2006, Journal of comparative pathology.

[68]  J. Langeveld,et al.  Immunopathology and Infectious Diseases Detection of Type 1 Prion Protein in Variant Creutzfeldt-Jakob Disease , 2005 .

[69]  A. Dickinson,et al.  Host-genotype and agent effects in scrapie incubation: Change in allelic interaction with different strains of agent , 2004, Molecular and General Genetics MGG.

[70]  H. Laude,et al.  New in vivo and ex vivo models for the experimental study of sheep scrapie: development and perspectives. , 2002, Comptes rendus biologies.

[71]  N. Hunter,et al.  Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie. , 2002, Journal of comparative pathology.

[72]  A. Giese,et al.  The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases. , 2000, The American journal of pathology.

[73]  Wood,et al.  Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641 , 2000, The Journal of general virology.

[74]  N. Hunter,et al.  Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641. , 1999, The Journal of general virology.

[75]  H. Fraser,et al.  Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation. , 1973, Journal of comparative pathology.

[76]  I. Zlotnik,et al.  Further observations on the experimental transmission of scrapie from sheep and goats to laboratory mice. , 1963, Journal of comparative pathology.

[77]  G. C. Millson,et al.  Scrapie produced experimentally in goats with special reference to the clinical syndrome. , 1961, Journal of comparative pathology.